TSH
Thyroid-stimulating hormone (TSH) is a pituitary hormone that regulates thyroid function in conjunction with thyrotropin-releasing hormone (TRH). Specifically, TSH induces production of Thyroxine (T4) which is converted triiodothyronine (T3) and is responsible for stimulating the metabolism. TSH is secreted throughout life but reaches high levels during the periods of rapid growth and development, as well as in response to stress.
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TSH Products (16)
| 姓名 | 种类 | 形式 | 宿主/来源 | 亚型 | 主要应用 | 单位 | 安全信息表 | COA | 点击此处订购样品 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,Pr | MG | MCT04-001 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,Pr | MG | MAT04-410 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,Pr | MG | MAT04-252 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,LF,WB | MG | MAT04-176 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,LF,WB | MG | MAT04-127 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,Pr | MG | MAT04-006 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,Pr | MG | MAT04-005 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,Pr | MG | MAT04-003 | View SDS | View COA | Order A Sample | ||
| MAb to TSH | Monoclonal | Purified | Mouse | IgG1,k | EIA,Pr | MG | MAT04-001 | View SDS | View COA | Order A Sample | ||
| Human TSH 98% Pure | Purified | Human Pituitary | N/A | N/A | MG | H6T04-323 | View SDS | View COA | Order A Sample | |||
| MAb to TSH Intact | Monoclonal | Purified | Mouse | IgG1 | EIA | MG | E86107M | View SDS | View COA | Order A Sample | ||
| MAb to Human TSH - Alpha | Monoclonal | Purified | Mouse | IgG1,k | EIA | MG | E20370M | View SDS | View COA | Order A Sample | ||
| MAb to TSH Beta | Monoclonal | Purified | Mouse | IgG1 | EIA | MG | E01328M | View SDS | View COA | Order A Sample | ||
| MAb to TSH Intact | Monoclonal | Purified | Mouse | IgG1 | EIA | MG | E01327M | View SDS | View COA | Order A Sample | ||
| MAb to TSH Beta | Monoclonal | Purified | Sheep | N/A | EIA,IHC,Pr,WB | MG | E01318S | View SDS | View COA | Order A Sample | ||
| Goat anti Human TSH - Beta | Polyclonal | Aff.Pur. | Goat | N/A | EIA,Pr,RIA | MG | D92409G | View SDS | View COA | Order A Sample |
激素&类固醇
产品资料
Meridian Air Dryable Direct StoolHormones & Steroids Catalog
甲状腺刺激(TSH)
TSH由垂体产生，其主要作用是控制甲状腺激素，甲状腺素(T4)和三碘甲状腺原氨酸(T3)的产生。 当T3和T4浓度较低时，TSH产量增加，而当T3和T4浓度较高时，TSH产量减少。 这种负反馈回路中的任何不平衡都可能是甲状腺疾病的指征，例如甲亢或甲状腺机能减退。
甲状腺功能亢进和甲状腺功能减退的最常见原因是自身免疫性疾病。在桥本氏病中，免疫系统攻击甲状腺并导致甲状腺功能减退。相反，格雷夫氏病引起甲状腺功能过度活跃导致甲状腺功能亢进。
Diagnosis
TSH serum measurements are used as a first-line screening assay to help diagnose thyroid disorders and to monitor treatment of hypothyroidism and hyperthyroidism. The capability of a TSH assay to distinguish between normal and subnormal concentrations is critical and quantification capabilities of 0.01 ml U/L or lower yields information that is useful to clinicians referring patients with subnormal TSH concentrations.
TSH assays are generally competitive or two-site immunoassays They are prone to interference from several sources including (1) macro-TSH (the circulating form of TSH) (2) biotin (3) anti-streptavidin antibodies (4) anti-ruthenium (-Ru) antibodies (5) TH autoantibodies and (6) heterophilic antibodies. Heterophilic antibodies can be mitigated using animal IgG and HAMA blockers, however, due to lack of time and high cost, routine screening for interference is not feasible for testing all samples. Therefore, only samples in which interference is suspected generally require additional tests to further characterize the interference.
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