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Parainfluenza

人类副流感病毒(HPIVs)通常会引起上呼吸道和下呼吸道传染病。HPIVs在健康成年人中造成的症状较轻,容易被忽略。但是HPIVs对免疫力低下的人群,比如婴儿,老人等可以造成生命威胁。

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姓名 种类 形式 宿主/来源 亚型 主要应用 单位   安全信息表 COA 点击此处订购样品
Parainfluenza Type 2 antigen   Lysate Vero Cells N/A EIA,WB ML R02902 View SDS View COA Order A Sample
Parainfluenza Type 3 antigen   Lysate Vero Cells N/A EIA,WB ML R02002 View SDS View COA Order A Sample
MAb-influenza B Nucleoprotein Monoclonal Purified Mouse IgG2b EIA,IFA,WB MG C87071M View SDS View COA Order A Sample
MAb to Parainfluenza Type 1&3 Monoclonal Purified Mouse IgG2a EIA,IFA,Pr MG C65738M View SDS View COA Order A Sample
MAb to Parainfluenza Type 1 Monoclonal Purified Mouse IgG2a EIA,IFA,Pr MG C65492M View SDS View COA Order A Sample
MAb to Parainfluenza Type 3 Monoclonal Purified Mouse IgG2a EIA,IFA,Pr MG C65467M View SDS View COA Order A Sample
MAb to Parainfluenza Type 3 Monoclonal Purified Mouse IgG2a EIA,IFA,Pr MG C65329M View SDS View COA Order A Sample
MAb to Parainfluenza Type 2 Monoclonal Purified Mouse IgG2a IFA MG C65300M View SDS View COA Order A Sample
MAb to Parainfluenza Type 2 Monoclonal Purified Mouse IgG2a IFA MG C65241M View SDS View COA Order A Sample
MAb to Parainfluenza 1 Monoclonal Purified Mouse IgG2b EIA,IFA MG C65122M View SDS View COA Order A Sample
MAb to Parainfluenza Type 3 Monoclonal Purified Mouse IgG2a EIA,LF,WB MG C01308M View SDS View COA Order A Sample
MAb to Parainfluenza Type 2 Monoclonal Purified Mouse IgG1 EIA,LF,WB MG C01307M View SDS View COA Order A Sample
MAb to Parainfluenza Type 1 Monoclonal Purified Mouse IgG2a EIA,LF,WB MG C01306M View SDS View COA Order A Sample
Goat anti-Parainfluenza 2+3 Polyclonal HRP Goat N/A EIA,ICC ML B65233G View SDS View COA Order A Sample
Goat anti-Parainfluenza 2&3 Polyclonal Purified Goat N/A EIA,IFA ML B65130G View SDS View COA Order A Sample
Goat anti Parainfluenza 1 Polyclonal Purified Goat N/A IFA ML B65121G View SDS View COA Order A Sample

副流感病毒

有四种类型的副流感病毒可以造成呼吸系统感染,具体的 感染类型,症状和感染部位取决于病毒的种类:

  • HPIV-1:造成儿童的格鲁布性喉头炎(声带附近或其它上呼吸道附近的肿胀)的主要原因
  • HPIV-2:也可以造成儿童的格鲁布性喉头炎,但是发生频率要低于HPIV-1。
  • HPIV-3:主要和毛细支气管炎和肺部感染发生相关。
  • HPIV-4:(包括4A和4B亚型):比较少见,但可以造成轻度或重度的呼吸系统疾病。
HPIV可以通过人与人之间的直接接触传播,也可以通过接触鼻腔或喉咙的分泌物传播。大多数儿童2岁之前易发生HPIV3感染,5岁之前易发生HPIV1和HPIV2感染。6个月以内的婴儿感染HPIV3易发生肺炎和毛细支气管炎。

诊断

实验室鉴定副流感病毒感染的方法包括:在培养的细胞中分离和检测病毒,免疫荧光法 (IFA) ,酶联免疫法 (EIA), 荧光免疫检测或聚合酶链式反应 (PCR)。同时,在感染后特定的IgG抗体显著增高(使用双份血清标本)可以证明为急性感染。但是每个副流感病毒亚型存在着的交叉反应使得很难区分它们。血凝集抑制试验(HIT),补体结合(CF)和中和实验(NT)可以被用来检测IgA,IgM和IgG的抗体效价,从而鉴别HPIV的类型。 在急性感染期,三分之二的病人血清中特异性的HPIV IgM抗体的效价较高,它可以存在2-11周。HPIV1,HPIV2和HPIV3的初期感染,在70-80%的病人中IgG抗体的会迅速增高(在10天内至少增加4倍)。新型的ELA检测依赖于纯化的病毒包膜糖蛋白和核蛋白。在鉴别诊断中,一些其它副粘液病毒也应该被鉴别,如腮腺炎病毒,肺炎病毒和猴病毒5型。他们均可与副流感病毒产生交叉反应。

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