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SARS

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a respiratory zoonotic virus first identified in February 2003 during an outbreak that emerged in China and spread to 4 other countries.
The novel SARS-CoV-2 is a genetically closely related coronavirus responsible for the 2020 COVID-19 pandemic. The virus was first identified in the respiratory tract of patients with pneumonia in Wuhan, Hubei China, in December 2019 and declared a pandemic by the World Health Organization (WHO) on March 11, 2020.

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姓名 种类 形式 宿主/来源 亚型 主要应用 单位   安全信息表 COA 点击此处订购样品
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1068 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1067 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF MG BN1066 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1065 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2a,k EIA,LF,Pr MG BN1064 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1063 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1062 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1061 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,l EIA,LF,Pr MG BN1060 View SDS View COA Order A Sample
rec-SARS-CoV-2 NP (Wuhan)   Purified, Liquid E. coli N/A EIA,LF MG BN1017 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD (Omicron) hFc   Purified, Liquid HEK Cells N/A EIA,LF MG BN1016 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD (Delta) hFc   Purified, Liquid HEK Cells N/A EIA,LF MG BN1015 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD (Beta) hFc   Purified, Liquid HEK Cells N/A EIA,LF MG BN1014 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag(Wuhan)hFc   Purified, Liquid HEK Cells N/A EIA,LF MG BN1013 View SDS View COA Order A Sample
rec-SARS-CoV-2 RBD Ag, (XE)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1011 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Omicron)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1010 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Mu)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1009 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Lambda)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1008 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Delta)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1007 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Beta)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1006 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Alpha)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1005 View SDS View COA Order A Sample
rec-SARS-CoV-2 RBD Ag (Wuhan)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1004 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1,P1(Gamma) Ag   Purified, Liquid HEK Cells N/A EIA,LF MG BN1003 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1, B.1.351 Ag   Purified, Liquid HEK Cells N/A EIA,LF MG BN1002 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1,S2 Ag(Wuhan)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1001 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1 Ag (Wuhan)   Purified, Liquid HEK Cells N/A EIA,LF MG BN1000 View SDS View COA Order A Sample
SARS-CoV-2 RBD,B.1.617.2delta   Purified, Liquid Insect Cells N/A EIA,WB MG 9606 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD B.1.617   Liquid Human N/A EIA,LF,WB,CLI MG 9599 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD, L452rMutant   Purified Insect Cells N/A EIA,LF,WB,CLI MG 9598 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified, Liquid Human Plasma IgG1 EIA,LF,Pr MG 9572 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD, P.1 Mutant   Purified Insect Cells N/A EIA,WB MG 9569 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD,B.1.351   Purified Insect Cells N/A EIA,LF,WB,CLI MG 9568 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD, Uk B.1.1.7   Purified Insect Cells N/A EIA,WB MG 9567 View SDS View COA Order A Sample
SARS-CoV-2, S1 Trimer   Purified Insect Cells N/A EIA,LF,WB,CLI MG 9566 View SDS View COA Order A Sample
MAb to SARS-CoV-2, Trimeric S1 Monoclonal Purified Cell Culture IgG1 EIA,WB,LF,Pr MG 9565 View SDS View COA Order A Sample
SARS-CoV-2 NP (His-tag)   Aff.Pur. Insect Cells N/A EIA,WB MG 9560 View SDS View COA Order A Sample
SARS-CoV-2 Spike S2 (His-tag)   Aff.Pur. Insect Cells N/A EIA,WB MG 9559 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (RBD)   Aff.Pur. Insect Cells N/A EIA,WB MG 9558 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (NTD)   Aff.Pur. Insect Cells N/A EIA,WB MG 9557 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (His-tag)   Aff.Pur. Insect Cells N/A EIA,WB MG 9556 View SDS View COA Order A Sample
SARS-CoV-2 NP (dykddddk-tag)   Aff.Pur. HEK Cells N/A EIA,LF,WB MG 9554 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (RBD)   Aff.Pur. HEK Cells N/A EIA,WB,LF MG 9552 View SDS View COA Order A Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG2b EIA,WB,LF,Pr MG 9551 View SDS View COA Order A Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG1 EIA,WB,LF,Pr MG 9550 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified Cell Culture IgG1 EIA,LF,WB MG 9549 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9548 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9547 View SDS View COA Order A Sample
SARS-CoV-2-Omicron Spike-RBD   Aff.Pur. HEK Cells N/A EIA,WB MG 9544 View SDS View COA Order A Sample
SARS-CoV, Spike (n-term) Recom   Purified E. coli N/A EIA,WB MG R18850 View SDS View COA Order A Sample
SARS-CoV, Spike (c-term) Recom   Purified E. coli N/A EIA,WB MG R18572 View SDS View COA Order A Sample
SARS-CoV, Spike (middle) Recom   Purified E. coli N/A EIA,WB MG R18526 View SDS View COA Order A Sample
SARS-CoV, E Protein, Recomb.   Purified E. coli N/A EIA,WB MG R18520 View SDS View COA Order A Sample
SARS-CoV, Nucl.(340-390) Recom   Purified E. coli N/A EIA,WB MG R18402 View SDS View COA Order A Sample
SARS-CoV, Nucl. (1-49) Recomb.   Purified E. coli N/A EIA,WB MG R18325 View SDS View COA Order A Sample
Rabbit A' SARS-CoV, Spike (ct) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88502R View SDS View COA Order A Sample
Rabbit A' SARS-CoV, Spike (nt) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88139R View SDS View COA Order A Sample

SARS-CoV-2

SARS-CoV-2是一种有包膜的RNA病毒,它有四种主要 的结构蛋白,包括刺突(S)蛋白、包膜(E)蛋白、膜(M)蛋 白和核衣壳(N)蛋白。S蛋白是一种跨膜蛋白,在病毒表面呈突出的三聚体结构,促使病毒通过ACE2受体与宿主细胞结合。N蛋白是冠状病毒RNA转录和复制所必需的结构成分。M蛋白主要决定了病毒包膜的形状,参与病毒的出芽和包膜的形成。E蛋白是SARS-CoV-2结构中最小的蛋白,在病毒的组装和释放中起作用,并且是发病机制所必需的。

人类感染SARS-CoV-2的发病机制表现为从轻微症状到严重呼吸衰竭。老年患者和严重疾病(如高血压、糖尿病、肥胖和心血管疾病)患者往往有更严重的后果,甚至有最高的死亡率。致死的主要原因是急性呼吸窘迫综合征(ARDS)引起的呼吸衰竭,这是由一种被称为“细胞因子风暴”的快速且无法控制的炎症级联信号引起的。细胞因子风暴的最初触发机制尚不清楚,但它可能与免疫系统检测到死亡细胞释放的大量病毒抗原有关。

诊断

用于诊断急性感染的COVID-19病毒检测依赖于使用鼻咽拭子检测SARS-CoV-2核酸或抗原。大多数抗原检测 方法能识别SARS-CoV-2 N蛋白的抗体,因为它是含量最高的病毒蛋白。S蛋白也是检测目标,特别是在可以使用其他样本类型如唾液或 鼻拭子的检测中,这些样本可以由个人收集。

血清学检测用于确定个体对SARS-CoV-2的免疫状态, 使用重组抗原检测IgA、IgG或IgM特异性抗体。对核蛋白检测IgG/IgM相对来说是灵敏度最高的,因为核蛋白浓度很高,因此会产生针对核蛋白的抗体。然而,S蛋白的RBD结构域是宿主附着蛋白,RBD抗体具有更强的特异性,预计具有中和作用。(Sethuraman, N. et al (2020). Interpreting Diagnostic Tests for SARSCoV-2. AMA. 323(22):2249-2251)。为了扩大检测的覆盖面,增加灵敏度和特异性,一些诊断厂家开始在单 一检测中使用几种抗原(如N, S1, RBD)。

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