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Hepatitis E Products (4)
| 姓名 | 种类 | 形式 | 宿主/来源 | 亚型 | 主要应用 | 单位 | 安全信息表 | COA | 点击此处订购样品 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HEV ORF2 Ag Recombinant | Purified | E. coli | N/A | EIA,WB | MG | R8A330 | View SDS | View COA | Order A Sample | |||
| HEV ORF3 Ag Recomb. | Purified | E. coli | N/A | EIA,WB | MG | R8A320 | View SDS | View COA | Order A Sample | |||
| HEV ORF2 Ag Recombinant | Purified | E. coli | N/A | EIA,WB | MG | R8A310 | View SDS | View COA | Order A Sample | |||
| HEV ORF2 And ORF3 Ag Recomb. | Purified | E. coli | N/A | EIA,WB | MG | R18250 | View SDS | View COA | Order A Sample |
Hepatitis
产品资料
Meridian Air Dryable Direct Stool血液检测的免疫和分子试剂
戊肝(HEV)
戊肝感染的临床病程可与甲肝类似，主要是一种自限性 疾病，死亡率较低。然而，在免疫系统较弱的个体中， 患慢性肝炎的风险很高。此外，对于孕妇(尤其是在妊娠 晚期)，这种疾病可能很严重，死亡率为25%，通常与一 种称为暴发性肝功能衰竭的临床综合征有关。HEV曾是 一种未被充分研究和忽视的病毒。然而，近年来，血液 制品对HEV的安全性越来越被重视。
戊型肝炎主要有四种基因型，其中1型和2型仅在人类中 发现。基因型3和4与人畜共患病传播有关(猪、野猪和 鹿)，在工业化国家通过食用未煮熟的动物肉引起零星感 染。从结构上看，HEV是一种无包膜病毒，其基因组由 三个开放阅读框(ORFs)组成。ORF1编码复制所需的非结 构蛋白(NS)， ORF2编码病毒衣壳的核心蛋白，ORF3部 分重叠ORF1编码类病毒蛋白。
Diagnosis
The commonly used tests for HEV infection are IgM and IgG anti-HEV antibody assays and molecular assays. HEV IgM antibodies appear early (from 1-4 weeks) in the course of illness and disappear over 4–5 months. Assays detecting anti-HEV are usually qualitative sandwich immunoassays developed with recombinant HEV antigens that provide a broad coverage of all 4 major HEV genotypes. The antigens typically represent part of the ORF2 and ORF3 proteins and studies have shown that assays based on open reading frame 2 (ORF2) can be more sensitive than those based on ORF3. Simultaneous assessment of anti-HEV IgA has been recommended to improve specificity as the IgM assay may cross-react with other IgM-based assays such as rheumatoid factor IgM. Overall recombinant protein-based tests have demonstrated an ability to detect anti-HEV in 90 to 95% of symptomatic HEV cases.
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