Platanus acerifolia, the London plane tree is a hybrid tree resulting from a cross between two sycamore species: Platanus occidentalis (American sycamore) and Platanus orientalis (Oriental plane). It is a very large deciduous tree that is resilient in urban conditions and a significant source of airborne allergens. Pla a 1 and Pla a 2 are major allergens for the London Plane tree and studies report that they are recognized by over 80% of sensitized Platanus-allergic individuals. A combination of Pla a 1 and Pla a 2, instead of the whole pollen extract, can be reliably used to diagnose plane pollen allergy in allergen-specific IgE testing.
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