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Thyroid Peroxidase (TPO)

Thyroid peroxidase (TPO) is an enzyme normally found in the thyroid gland which plays an important role in the production of thyroid hormones, converting the thyroid hormone T4 to T3. It is one of the most important thyroid gland antigens and along with thyroglobulin (Tg), it is targeted by the immune system in several autoimmune thyroid diseases.

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Type
Format
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Tested Apps
Unit
Catalog
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Thyroid Peroxidase, Recomb.
Antigen
Purified
HEK293 cells
N/A
N/A
MG
R01683
MAb to Thyroid Peroxidase
Monoclonal
Purified
Mouse
IgG1
N/A
MG
E86415M
Human Tpo, Recombinant
Antigen
Aff.Pur.
Baculovirus
N/A
EIA
MG
A01309H
MAb to Thyroid Peroxidase
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
E01309M
MAb to Thyroid Peroxidase
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
E01310M
MAb to Thyroid Peroxidase
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
E01311M

Thyroid Peroxidase (TPO)

As an enzyme, the role of TPO is to catalyze the oxidation of iodide on tyrosine residues in thyroglobulin for the synthesis of triiodothyronine (T3) and thyroxine (T4). Diseases associated with TPO are usually autoimmune related and thyroid peroxidase is a frequent epitope of autoantibodies which generates anti-thyroid peroxidase antibodies (anti-TPO antibodies). Consequently, anti-TPO antibodies are detectable in most autoimmune disorders including Hashimoto thyroiditis and Grave’s disease and may also be found in patients with non-thyroid autoimmune diseases such as pernicious anemia, type I diabetes, or other disorders that activate the immune system.

Diagnosis

The TPO antibody assay is the most sensitive test for autoimmune thyroid disease, and it is useful in differentiating thyroid autoimmune disorders from non-autoimmune goiter or hypothyroidism. It employs both non-competitive and competitive assay formats using TPO antigen. Traditionally, human native TPO purified from thyroid glands was used; however, studies have shown that the soluble extracellular domain of recombinant human thyroid peroxidase (rTPO) produced in insect cells has immunochemical properties similar to native human thyroid peroxidase (Haubruck et al. 1993).

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