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Influenza

Influenza is a highly infectious respiratory illness caused by the influenza virus. Common symptoms include fatigue, fever, chills, a hacking cough, and body aches which can self-resolve in 1-2 weeks. However, complications can arise including life-threatening secondary infections. Influenza is a serious disease, and approximately 1 in 1,000 cases result in death.

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Clear Results
130 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
MAb to Influenza A (matrix)
Monoclonal
Purified
Mouse
IgG1
N/A
MG
C01298M
MAb to Influenza B Np
Monoclonal
Purified
Mouse
IgG2b
N/A
MG
C01302M
Influenza A Nucleoprotein
Antigen, Other
Purified, Liquid
-
N/A
N/A
MG
9593
Influenza B Nucleoprotein
Antigen, Other
Purified, Liquid
E. coli
N/A
N/A
MG
9594
MAb Influenza A
Monoclonal
Purified, Liquid
-
IgG1
EIA
MG
9586
MAb Influenza B
Monoclonal
Purified, Liquid
-
IgG2b
EIA
MG
9587
Influenza A (a/wisconsin)
Antigen, Other
Purified
Chicken Eggs
N/A
IM
MG
R01250
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG1
LF
MG
C01735M
Influenza A (a/solomon Island)
Antigen, Other
Purified
Chicken Eggs
N/A
IM
MG
R01245
Influenza A (H1N1)
Antigen, Other
Purified
Chicken Eggs
N/A
CON, EIA
ML
R01698
Parainfluenza Type 2 antigen
Antigen, Other
Lysate
Vero Cells
N/A
EIA, WB
ML
R02902
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
C01737M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG2b
EIA, LF, Pr
MG
C01760M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2a
LF, Pr
MG
C01900M
Influenza B (b/florida/04/06)
Antigen, Other
Purified
Chicken Eggs
N/A
IM
MG
R01246
Influenza B (b/florida/07/04)
Antigen, Other
Purified
Chicken Eggs
N/A
IM
MG
R01247
Influenza B (b/malaysia)
Antigen, Other
Purified
Chicken Eggs
N/A
IM
MG
R01248
Influenza A (a/brisbane/10/07)
Antigen, Other
Purified
Chicken Eggs
N/A
IM
MG
R01249
Parainfluenza Type 3 antigen
Antigen, Other
Lysate
Vero Cells
N/A
EIA, WB
ML
R02002
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2a
LF, Pr
MG
C01897M
Influenza A (H3N2) antigen
Antigen, Other
Purified
Chicken Eggs
N/A
EIA, WB
ML
R01623
Influenza B (b/hong Kong 5/72)
Antigen, Other
Purified
MDCK Cells
N/A
EIA
ML
R02310
MAb to Parainfluenza 1
Monoclonal
Purified
Mouse
IgG2b
EIA, IFA
MG
C65122M
MAb to Parainfluenza Type 2
Monoclonal
Purified
Mouse
IgG2a
IFA
MG
C65241M
MAb to Influenza A Nucleoprot.
Monoclonal
FITC
Mouse
IgG2a
IFA, IHC
MG
C65341F
Goat anti-influenza A
Polyclonal
HRP
Goat
N/A
EIA
ML
B65314G
Goat anti-influenza A
Polyclonal
Biotin
Goat
N/A
IFA, IHA
ML
B65317G
Goat anti Influenza B Virions
Polyclonal
Biotin
Goat
N/A
EIA, IFA, WB
ML
B65342G
Goat anti Influenza B Virions
Polyclonal
HRP
Goat
N/A
EIA, IFA, WB
ML
B65344G
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG2a
IFA
MG
C01244M
Goat anti Parainfluenza 1
Polyclonal
Purified
Goat
N/A
IFA
ML
B65121G
Goat anti-Parainfluenza 2&3
Polyclonal
Purified
Goat
N/A
EIA, IFA
ML
B65130G
Goat anti-influenza A
Polyclonal
Biotin
Goat
N/A
IFA, IHC(p)
ML
B65241G
Goat anti-influenza A
Polyclonal
FITC
Goat
N/A
IFA, IHC(p)
ML
B65242G
Goat anti Influenza A-virions
Polyclonal
HRP
Goat
N/A
EIA, IHC(p)
ML
B65243G
Goat anti Influenza A M1
Polyclonal
Biotin
Goat
N/A
EIA, IFA
ML
B65246G
Goat anti Influenza A M1
Polyclonal
FITC
Goat
N/A
IFA
ML
B65247G
Goat anti Influenza A M1
Polyclonal
HRP
Goat
N/A
EIA, ICC
ML
B65248G
Goat anti-influenza A
Polyclonal
Purified
Goat
N/A
IFA, IHA
ML
B65311G
Goat anti-influenza A
Polyclonal
FITC
Goat
N/A
IFA, IHA
ML
B65313G
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2a
EIA, WB
MG
C01763M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2b
LF, Pr
MG
C01746M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2a
LF, Pr
MG
C01747M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
C01748M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2a
LF, Pr
MG
C01749M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG2a
EIA, LF
MG
C01739M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, LF, Pr
MG
C01731M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
C01732M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG2a
EIA, LF, Pr
MG
C01734M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG2a
EIA, LF, Pr
MG
C01736M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG2b
EIA, LF, Pr
MG
C01738M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, LF
MG
C01740M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
C01741M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2a
LF, Pr
MG
C01742M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
C01743M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2b
LF, Pr
MG
C01744M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2b
EIA, LF, Pr
MG
C01745M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
C01691M
MAb to Influenza A H5
Monoclonal
HRP
Mouse
IgG2a
DB, EIA, HI
MG
C86490P
MAb to Influenza A Virus
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, Pr
MG
C65385M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2a
EIA, WB
MG
C01684M
MAb to Parainfluenza Type 1
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65492M
MAb to Influenza B Virus
Monoclonal
Purified
Mouse
IgG2b
IFA, LF, Pr
MG
C65081M
Goat anti-Parainfluenza 2+3
Polyclonal
HRP
Goat
N/A
EIA, ICC
ML
B65233G
MAb to Influenza A Virus
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, Pr
MG
C65365M
MAb to Influenza B Virus
Monoclonal
Purified
Mouse
IgG2b
IFA, LF, Pr
MG
C65016M
MAb to Influenza B Virus
Monoclonal
Purified
Mouse
IgG2b
IFA, LF, Pr
MG
C65131M
MAb to Influenza A Virus
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, Pr
MG
C65375M
MAb to Influenza A Virus
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65331M
MAb to Parainfluenza Type 3
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65329M
MAb to Influenza A Nucleoprot.
Monoclonal
Purified
Mouse
IgG2a
IFA, IHC
MG
C65341M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
C01321M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr, WB
MG
C01323M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr, WB
MG
C01326M
Goat anti-influenza A(virions)
Polyclonal
Purified
Goat
N/A
IFA, IHC(p)
ML
B65141G
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
C01327M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
C01328M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
C01329M
MAb to Influenza A H5N1
Monoclonal
Aff.Pur.
Mouse
IgG3
EIA
MG
C88200M
MAb to Influenza A H5N1
Monoclonal
Aff.Pur.
Mouse
IgG
EIA
MG
C88205M
Influenza A N1 (swine) Peptide
Antigen, Other
Purified
Synthetic
N/A
EIA
MG
R01421
MAb to Influenza A H1
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
C01282M
Influenza A H1 Peptide
Antigen, Other
Purified
Synthetic
N/A
EIA
MG
R01423
Influenza A H5N1 Hemagglutinin
Antigen, Other
Purified
Synthetic
N/A
EIA, HA
MG
R88540
Influenza A H5N1 Hemagglutinin
Antigen, Other
Purified
Synthetic
N/A
EIA, HA
MG
R88240
Influenza A H5N1 Neuraminidase
Antigen, Other
Purified
Synthetic
N/A
EIA
MG
R88340
MAb to Parainfluenza Type 3
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65467M
Goat anti-influenza A M1
Polyclonal
Purified
Goat
N/A
EIA, IFA
ML
B65143G
MAb to Parainfluenza Type 1&3
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65738M
Influenza A H1 (swine) Peptide
Antigen, Other
Purified
Synthetic
N/A
EIA
MG
R01419
Influenza A H5N1 Hemagglutinin
Antigen, Other
Purified
Synthetic
N/A
EIA
MG
R88640
MAb to Influenza A H1
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01283M
Influenza B(b/victoria/504/00)
Antigen, Other
Purified
Chicken Eggs
N/A
EIA
MG
R86350
MAb to Influenza B Virus
Monoclonal
Purified
Mouse
IgG2b
IFA, LF, Pr
MG
C65107M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG2a
EIA, HI, Pr
MG
C01310M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01309M
MAb to Influenza A H1
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
C01281M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG2a
DB, EIA, HI
MG
C86270M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG2a
DB, EIA, HI, Pr
MG
C86240M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG2a
DB, EIA, HI, Pr
MG
C86280M
MAb to Influenza A H1
Monoclonal
Purified
Mouse
IgG1
EIA, HI, ICC, IFA
MG
C86304M
MAb to Parainfluenza Type 2
Monoclonal
Purified
Mouse
IgG2a
IFA
MG
C65300M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01341M
MAb to Influenza A (matrix)
Monoclonal
Purified
Mouse
IgG1
IFA, WB
MG
B87020M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG1
EIA, HI
MG
C01312M
Influenza A (a/panama/2007/99)
Antigen, Other
Purified
Chicken Eggs
N/A
EIA
MG
R86288
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG1
EIA
MG
C01325M
Influenza A(a/beijing/262/95)
Antigen, Other
Purified
Chicken Eggs
N/A
EIA
MG
R86280
MAb to Influenza A
Monoclonal
Purified
Mouse
IgG2a
ICC
MG
C86305M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01342M
MAb to Influenza A H3
Monoclonal
Purified
Mouse
IgG2a
EIA, WB
MG
C01319M
MAb to Influenza B (matrix M1)
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01346M
Influenza A H5N1 NS2
Antigen, Other
Purified
Synthetic
N/A
EIA
MG
R88245
MAb to Influenza A H3
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01318M
MAb to Influenza B (matrix M1)
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01345M
MAb to Influenza A (NP)
Monoclonal
Purified
Mouse
IgG3
EIA
MG
C01324M
MAb to Influenza A H5
Monoclonal
Purified
Mouse
IgG2a
DB, EIA, HI
MG
C86490M
Influenza A (a/new Caledonia)
Antigen, Other
Purified
Chicken Eggs
N/A
EIA
MG
R86380
MAb to Influenza B HA2
Monoclonal
Purified
Mouse
IgG2b
EIA, WB
MG
C01276M
MAb to Influenza A H7
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01610M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01340M
Influenza A H5N1 NS1
Antigen, Other
Purified
Synthetic
N/A
EIA
MG
R88235
MAb to Influenza A H7
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01611M
MAb to Influenza B (NP)
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01343M
MAb to Influenza B HA2
Monoclonal
Purified
Mouse
IgG2a
EIA, WB
MG
C01275M
Influenza B (b/tokyo/53/99)
Antigen, Other
Purified
Chicken Eggs
N/A
EIA
MG
R86250
Influenza A (a/kiev/301/94)
Antigen, Other
Purified
Chicken Eggs
N/A
EIA, IM
MG
R86480
Influenza A (a/shangdong/9/93)
Antigen, Other
Purified
Chicken Eggs
N/A
EIA
MG
R86874
MAb-influenza B Nucleoprotein
Monoclonal
Purified
Mouse
IgG2b
EIA, IFA, WB
MG
C87071M
MAb to Influenza A H7
Monoclonal
Purified
Mouse
IgG2b
EIA, WB
MG
C01609M

Influenza

There are three main types of influenza virus (Types A, B, and C) that cause infection in humans and these are further characterized into subtypes and strains. The continued emergence of new flu strains each year is due to the ability of the influenza virus to mutate slowly (through small genetic changes called antigenic drift) and quickly through a process called reassortment. Antigenic drift is responsible for the seasonal variations every year and reassortment is responsible for the development of new strains that can cause pandemics.

Influenza type A (Flu A) viruses are especially prone to reassortment due to their wide host range (humans, dogs, birds, pigs, horses, whales, seals, and other animals). Specifically, the Flu A genome is made up of eight loosely linked segments, each of which harbors at least one important gene. Those genes direct the expression of the major viral proteins such as hemagglutinin (HA) and neuraminidase (NA). In the process of viral reproduction, the linkages between the eight segments of the Flu A genome break apart. Since it is possible for two different Flu A strains to infect a cell simultaneously, some of the genetic segments from one strain can be swapped with another during reproduction. For instance, if a human flu virus and a bird flu virus infect a person, reassortment can intermingle genes from both viruses during replication and create a virus with a protein against which humans have little or no immunity, plus human influenza genes that are more likely to cause sustained human-to-human transmission. In contrast, Influenza B (Flu B) and C viruses do not cause pandemics, most likely due to their limited host range of only humans.

Flu A virus is the most common flu virus infecting humans, animals, and birds. It is divided into subtypes, based on the nature of their surface glycoproteins, HA and NA. There are 18 different HAs and 11 NAs that are distinguishable serologically (antibodies to one virus subtype do not react with another). In comparison, Flu B infection mostly occurs in humans and is divided into lineages and strains. Currently circulating influenza B viruses belong to one of the two lineages: B/Victoria and B/Yamagata. This virus is responsible for significant morbidity which is why the seasonal trivalent influenza vaccine contains Flu B as an integral component. Unlike Flu A or B, Influenza C viruses only cause a mild respiratory illness in humans and secondary complications are rare. Flu C is structurally different from Flu A and B viruses and contains a glycoprotein called HEF (hemagglutinin-esterase-fusion).

Influenza viruses are mostly spread by aerosolization made when an infected person coughs or sneezes. Complications usually arise from bacterial infections of the lower respiratory tract and signs of a secondary respiratory infection often appear just as the infected person seems to be recovering. The elderly and the chronically ill are at greater risk for secondary infection and other complications. Children can also experience a rare, but serious complication called Reye’s syndrome.

Diagnosis

Diagnostic influenza tests help the identification of influenza types A and B and influenza A subtypes 2009 H1N1, H1, H3, H5, N1, and N2. Influenza tests include rapid influenza diagnostic tests (RIDTs), direct fluorescent antibody stains, viral cultures, and molecular assays.

RIDTs have become routine influenza tests since their initial FDA approval in 1999, and they typically detect both Type A and B influenza. They are easy to use, relatively inexpensive, and provide rapid results in 10-30 minutes, allowing physicians to prescribe antivirals in the relatively small window of effectiveness (1-2 days after onset of symptoms). The performance of RIDTs is highly dependent on the quality of reagents, proficiency of operation, transport and storage conditions, time from illness onset to sample collection, and the emergence of genomic variations and novel strains. Many RIDTs detect the nucleoprotein (NP), which is one of the more conserved proteins in the influenza virus and subsequently less likely to undergo mutations that lead to antigenic drift (which in turn can cause the functional components of an RIDT to not recognize a current influenza strain). The major limitation of currently available RIDTs is their low and variable sensitivity. To obtain a true increase in assay sensitivity, monoclonal antibodies capable of recognizing existing and emerging strains are critical.

Get In Touch With A Specialist

Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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