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Insulin (C-peptide)

Insulin is a peptide hormone secreted by the β cells of the pancreatic islets of Langerhans and maintains normal blood glucose levels by facilitating cellular glucose uptake, regulating carbohydrate, lipid and protein metabolism and promoting cell division and growth through its mitogenic effects. C-peptide is a byproduct created when insulin is produced. Both insulin and C-peptide are created from a larger molecule called proinsulin which undergoes enzymatic cleavage to become des-31,32-proinsulin and des-64,65-proinsulin and eventually, insulin and C-peptide (an inactive peptide chain).

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Clear Results
22 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
MAb to Insulin
Monoclonal
HRP
Mouse
IgG1,k
N/A
MG
E86802P
MAb to Insulin
Monoclonal
Biotin
Mouse
IgG1,k
EIA
MG
E86306B
MAb to IGFBP-3
Monoclonal
Purified
Mouse
IgG1
CLIA, EIA, Pr, RIA
MG
K01410M
MAb to Insulin/proinsulin, Rat
Monoclonal
Purified
Mouse
IgG1
EIA, IHC(f), Pr
MG
E01346M
MAb to Insulin/proinsulin, Rat
Monoclonal
Purified
Mouse
IgG1
EIA, IHC(f), Pr
MG
E01345M
MAb to Insulin/proinsulin, Rat
Monoclonal
Biotin
Mouse
IgG1
EIA, IHC(f), Pr
MG
E01345B
MAb to Proinsulin
Monoclonal
Purified
Mouse
IgG1
EIA
MG
E01339M
MAb to IGF-Ir
Monoclonal
Purified
Mouse
IgG1
IB
MG
K55170M
MAb to Somatomedin C
Monoclonal
Purified
Mouse
IgG1
EIA, RIA
MG
E54061M
MAb to IGFBP-1
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr, WB
MG
K01346M
MAb to Insulin/proinsulin, Rat
Monoclonal
Purified
Mouse
IgG1,k
EIA, IHC(f), Pr
MG
E86210M
MAb to Insulin
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
E86306M
MAb to Insulin
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
E86102M
MAb to IGFBP-1
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
K01345M
MAb to Insulin C-terminal
Monoclonal
Purified
Mouse
IgG1,k
EIA
MG
E86211M
MAb to Insulin
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
E86802M
MAb to Insulin
Monoclonal
Purified
Mouse
IgG1,k
EIA
MG
E86705M
MAb to Proinsulin
Monoclonal
Purified
Mouse
IgG1,k
EIA, IHC(f), Pr
MG
E86104M
MAb to Proinsulin
Monoclonal
Purified
Mouse
IgG1,k
EIA, IHC(f), Pr
MG
E86209M
MAb to C-peptide
Monoclonal
Liquid
Mouse
IgG1
EIA, RIA
MG
E86710M
MAb to IGFBP-1
Monoclonal
Purified
Mouse
IgG2a
EIA, WB
MG
K86010M
MAb to C-peptide (proinsulin)
Monoclonal
Purified
Mouse
IgG1
EIA, RIA
MG
E86588M

Insulin (C-peptide)

Disorders had three typos, please replace as follows: Disorders most common to insulin and c-peptide dysregulation include diabetes, insulinomas (a tumor of the pancreas that causes excess insulin to be produced), hypokalaemia, Cushing’s syndrome, and kidney disease. The measurement of plasma insulin, C-peptide and proinsulin concentrations have been identified as the most useful test in identifying causes of hyperglycemia (high blood glucose) such as Type 1 and Type 2 diabetes which are chronic metabolic diseases due either to a lack of insulin secretion or reduced insulin sensitivity. Overall, raised levels indicate endogenous hyperinsulinaemia, which is often seen in people with early-stage type 2 diabetes mellitus, and low levels indicate type 1 diabetes.

Diagnosis

Early assays for insulin, proinsulin, and C-peptide were competitive RIAs, however, most commercial assays are now competitive (Insulin and C-peptide) or two-site enzyme immunoassays (total or intact proinsulin).

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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