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Hepatitis A

Hepatitis A (HAV) is a contagious disease, spread by contact with infected people, their fluids and waste. It causes an acute infection of the liver that generally does not require treatment and can self-resolve. Young children infected with HAV typically have a milder form of the disease compared to adults who can be at risk of acute liver failure, especially if there is underlying chronic liver disease. HAV can affect people of all ages but can be prevented with vaccination.

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Hepatitis A Products (12)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
HAV Grade II Concentrate Antigen Purified FRhK-4 Cells N/A EIA,CLI,WB ML 8505 View SDS View COA Order A Sample
Hepatitis A antigen Antigen Purified FRhK-4 Cells N/A EIA,WB,CLI ML 8198 View SDS View COA Order A Sample
HAV Vp3 Recomb. Antigen Purified E. coli N/A EIA,WB MG R18610 View SDS View COA Order A Sample
MAb Hepatitis A Virus (HAV) Monoclonal Purified Mouse IgG2a EIA MG C65885M View SDS View COA Order A Sample
MAb to Hepatitis A Virus Monoclonal Purified Mouse IgG1 EIA,IFA,IHC MG C65881M View SDS View COA Order A Sample
MAb to Hepatitis A Virus Monoclonal Purified Mouse IgG2a EIA,IFA MG C01855M View SDS View COA Order A Sample
MAb to Hepatitis A Virus Monoclonal Purified Mouse IgG2b EIA,IFA MG C01854M View SDS View COA Order A Sample
MAb to Hepatitis A Virus Monoclonal Purified Mouse IgG1 EIA,IFA MG C01853M View SDS View COA Order A Sample
Goat A' Hepatitis A Strn HM175 Polyclonal Purified Goat N/A EIA ML B65808G View SDS View COA Order A Sample
Mab to Hepatitis A Monoclonal Purified Ascites IgG3,k EIA,LF,Pr MG BN1156 View SDS View COA Order A Sample
Mab to Hepatitis A Monoclonal Purified Ascites IgG3,k EIA,LF,Pr MG BN1155 View SDS View COA Order A Sample
Mab to Hepatitis A Monoclonal N/A Ascites IgG2a,k EIA,LF,Pr MG BN1154 View SDS View COA Order A Sample

Hepatitis A (HAV)

Symptomatic HAV infections affect about 1.4 million people globally per year and the CDC estimates that 10% to 15% of people with HAV will have symptoms that persist or reoccur over a 6- to 9-month period. The virus is highly contagious and primarily transmitted by the fecal-oral route, by either person-to-person contact or through consumption of contaminated food or water. Currently, the most commonly identified risk factor among reported cases of acute HAV infection is contact with an infected household member or sexual partner. Antibodies produced in response to Hepatitis A last for life and protect against reinfection, although the best way to prevent Hepatitis A is by getting vaccinated.

Diagnosis

Hepatitis A cannot be distinguished from other types of viral hepatitis on the basis of clinical symptoms alone. For this reason, serologic tests that identify the presence of antibodies to HAV is the primary method for diagnosis. HAV specific anti-IgM indicates an acute infection and is detectable from 1-2 weeks after initial infection and persists for up to 14 weeks. A positive IgG result signifies that the acute stage of the illness past and the person is immune to further infection. IgG antibody to HAV is also found in the blood following vaccination. HAV has several critical immunogenic epitopes which require precise folding and to-date, recombinant techniques have not been able to mimic the conformation of these epitopes. As a result, most commercial HAV immunoassays use native HAV antigen as opposed to recombinant HAV proteins for antibody detection.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!


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