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Pregnancy Associated Plasma Protein-A (PAPP-A)

Pregnancy associated plasma protein-A (PAPP-A) is as a glycoprotein found in the serum of pregnant women. It is produced by the placenta and circulates in the form of a heterotetramer complexed with eosinophil major basic protein (proMBP). Its main role in pregnancy is to prevent the recognition of the fetus by the maternal immune system. In non-pregnant individuals, PAPP-A can also be produced by several cell types and detected at much lower levels (and in the form of a homodimer). Studies have shown that it can also be used as a potential biomarker for plaque instability in cardiac disease.

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7 Results
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Type
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MAb to PAPP-A
Monoclonal
Purified
Mouse
IgG2b
EIA
MG
E01367M
MAb to PAPP-A
Monoclonal
Purified
Mouse
IgG2b
EIA
MG
E01368M
MAb to PAPP-A
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
E86141M
MAb to PAPP-A
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
E86910M
MAb to PAPP-A
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
E01261M
MAb to PAPP-A (proMBP)
Monoclonal
Purified
Mouse
IgG2b
EIA
MG
E86114M
MAb to PAPP-A (proMBP)
Monoclonal
Purified
Mouse
IgG2b
EIA
MG
E86509M

Pregnancy Associated Plasma Protein-A (PAPP-A)

Pregnancy-associated plasma protein-A (PAPP-A) largest of the pregnancy associated proteins produced by both the embryo and the placenta during pregnancy. In the first trimester of pregnancy a low PAPP-A level can also be associated Trisomy 21 or Down Syndrome and other pregnancy complications such as fetal growth restriction, fetal demise, preterm birth, and pre-eclampsia in the third trimester.

As a cardiac marker, high PAPP-A serum levels indicate a risk for acute coronary syndromes (unstable angina and acute myocardial infarction), as PAPP-A is expressed by unstable and ruptured coronary artery plaques, but not stable plaques.

Diagnosis

Serum PAPP-A assays are based the two-site sandwich immunoassay principle. In pregnancy, PAPP-A assays that employ antibodies to detect the heterotrimeric form (htPAPP-A/proMBP complex) are used in conjunction with hCG or free beta hCG to screen for aneuploidies and adverse pregnancy outcomes. For cardiac PAPP-A diagnostics, antibodies that detect the homodimeric subunit dPAPP-A are used.

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