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SARS

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a respiratory zoonotic virus first identified in February 2003 during an outbreak that emerged in China and spread to 4 other countries.
The novel SARS-CoV-2 is a genetically closely related coronavirus responsible for the 2020 COVID-19 pandemic. The virus was first identified in the respiratory tract of patients with pneumonia in Wuhan, Hubei China, in December 2019 and declared a pandemic by the World Health Organization (WHO) on March 11, 2020.

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SARS Products (56)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1068 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1067 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF MG BN1066 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1065 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2a,k EIA,LF,Pr MG BN1064 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1063 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1062 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1061 View SDS View COA Order A Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,l EIA,LF,Pr MG BN1060 View SDS View COA Order A Sample
rec-SARS-CoV-2 NP (Wuhan) Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1017 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD (Omicron) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1016 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD (Delta) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1015 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD (Beta) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1014 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag(Wuhan)hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1013 View SDS View COA Order A Sample
rec-SARS-CoV-2 RBD Ag, (XE) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1011 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Omicron) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1010 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Mu) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1009 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Lambda) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1008 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Delta) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1007 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Beta) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1006 View SDS View COA Order A Sample
r-SARS-CoV-2 RBD Ag, (Alpha) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1005 View SDS View COA Order A Sample
rec-SARS-CoV-2 RBD Ag (Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1004 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1,P1(Gamma) Ag Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1003 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1, B.1.351 Ag Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1002 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1,S2 Ag(Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1001 View SDS View COA Order A Sample
rec-SARS-CoV-2 S1 Ag (Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1000 View SDS View COA Order A Sample
SARS-CoV-2 RBD,B.1.617.2delta Antigen Purified, Liquid Insect Cells N/A EIA,WB MG 9606 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD B.1.617 Antigen Liquid Human N/A EIA,LF,WB,CLI MG 9599 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD, L452rMutant Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9598 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified, Liquid Human Plasma IgG1 EIA,LF,Pr MG 9572 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD, P.1 Mutant Antigen Purified Insect Cells N/A EIA,WB MG 9569 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD,B.1.351 Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9568 View SDS View COA Order A Sample
SARS-CoV-2 S1 RBD, Uk B.1.1.7 Antigen Purified Insect Cells N/A EIA,WB MG 9567 View SDS View COA Order A Sample
SARS-CoV-2, S1 Trimer Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9566 View SDS View COA Order A Sample
MAb to SARS-CoV-2, Trimeric S1 Monoclonal Purified Cell Culture IgG1 EIA,WB,LF,Pr MG 9565 View SDS View COA Order A Sample
SARS-CoV-2 NP (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9560 View SDS View COA Order A Sample
SARS-CoV-2 Spike S2 (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9559 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (RBD) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9558 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (NTD) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9557 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9556 View SDS View COA Order A Sample
SARS-CoV-2 NP (dykddddk-tag) Antigen Aff.Pur. HEK Cells N/A EIA,LF,WB MG 9554 View SDS View COA Order A Sample
SARS-CoV-2 Spike S1 (RBD) Antigen Aff.Pur. HEK Cells N/A EIA,WB,LF MG 9552 View SDS View COA Order A Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG2b EIA,WB,LF,Pr MG 9551 View SDS View COA Order A Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG1 EIA,WB,LF,Pr MG 9550 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified Cell Culture IgG1 EIA,LF,WB MG 9549 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9548 View SDS View COA Order A Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9547 View SDS View COA Order A Sample
SARS-CoV-2-Omicron Spike-RBD Antigen Aff.Pur. HEK Cells N/A EIA,WB MG 9544 View SDS View COA Order A Sample
SARS-CoV, Spike (n-term) Recom Antigen Purified E. coli N/A EIA,WB MG R18850 View SDS View COA Order A Sample
SARS-CoV, Spike (c-term) Recom Antigen Purified E. coli N/A EIA,WB MG R18572 View SDS View COA Order A Sample
SARS-CoV, Spike (middle) Recom Antigen Purified E. coli N/A EIA,WB MG R18526 View SDS View COA Order A Sample
SARS-CoV, E Protein, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18520 View SDS View COA Order A Sample
SARS-CoV, Nucl.(340-390) Recom Antigen Purified E. coli N/A EIA,WB MG R18402 View SDS View COA Order A Sample
SARS-CoV, Nucl. (1-49) Recomb. Antigen Purified E. coli N/A EIA,WB MG R18325 View SDS View COA Order A Sample
Rabbit A' SARS-CoV, Spike (ct) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88502R View SDS View COA Order A Sample
Rabbit A' SARS-CoV, Spike (nt) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88139R View SDS View COA Order A Sample

SARS-CoV-2

SARS-CoV-2 is an enveloped RNA virus that has four main structural proteins including spike (S) glycoprotein, small envelope (E) glycoprotein, membrane (M) glycoprotein, and the nucleocapsid (N) protein. The spike or S glycoprotein is a transmembrane protein that forms homotrimers which protrude from the viral surface and facilitate the binding of envelope viruses to host cells via ACE2-receptors. The nucleocapsid (N protein) is the structural component of the virus necessary for viral RNA transcription and replication. The membrane or M protein plays a role in determining the shape of the virus envelope, helps to stabilize nucleocapsids and promotes the completion of viral assembly. The envelope or E protein is the smallest protein in the SARS-CoV-2 structure, and it plays a role in the production and maturation of this virus.

The pathogenesis of SARS-CoV-2 infection in humans manifests itself as mild symptoms to severe respiratory failure. Elderly patients and those with serious pre-existing diseases (e.g. hypertension, diabetes, obesity, and cardiovascular disease) tend to have more severe outcomes and the highest death rate. The main cause of death is from respiratory failure due to acute respiratory distress syndrome (ARDS) brought on by a rapid and uncontrolled inflammatory signaling cascade called a “cytokine storm”. The initial trigger for the cytokine storm is not yet known but it likely involves the immune system’s detection of a large quantity of viral antigens released by dying cells.

Diagnosis

Viral tests for COVID-19 that diagnose an acute infection rely on the detection SARS-CoV-2 nucleic acid or antigen using nasopharyngeal swabs. Most antigen detection assays use antibodies that recognize SARS-CoV-2 nucleocapsid protein as it is the most abundant viral protein. Spike protein has also been targeted, especially in assays that use alternative sample types such as saliva or nasal swabs that can be collected by an individual.

Serology tests to determine an individual’s immune status to SARS-CoV-2 use recombinant antigens to detect IgA, IgG or IgM specific antibodies. Tests that detect IgG/IgM to the nucleoprotein are relatively the most sensitive due to the high concentration of nucleoprotein and consequently, antibodies generated against the nucleoprotein. However, the RBD domain of the S-protein is the host attachment protein, and antibodies to RBD are more specific and can be neutralizing. (Sethuraman, N. et al (2020). Interpreting Diagnostic Tests for SARS-CoV-2.AMA. 323(22):2249-2251). To broaden an assay’s coverage and increase its sensitivity and specificity, several diagnostics manufactures use several antigens (e.g. N, S1, RBD) within a single assay.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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