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Scl-70

Scl-70 antigen is an abundant nuclear protein that is an extractable fragment (70 kD) of a larger protein (100-105kD), Topoisomerase I. Anti-Scl-70 antibodies are a serologic marker of diffuse cutaneous systemic sclerosis (dcSSc), a connective tissue disease characterized by microvascular damage and fibrosis of the skin and visceral organs. Autoantibodies to Scl-70 are also a specific serologic marker for systemic sclerosis and acrosclerosis, but are not usually present in other autoimmune rheumatic diseases unless some cutaneous symptoms of scleroderma are present.

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4 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
Human anti Scl-70 antigen
Polyclonal
Purified
Human Donor
N/A
EIA, ID
ML
K07105H
Positive Control St Autoimmune
Polyclonal
Purified
Human Donor
N/A
EIA, ID
ST
K07110H
Scl-70 antigen
Antigen, Other
Aff.Pur.
Rabbit Thymus
N/A
EIA
UT
A07322B
Scl-70 antigen
Antigen, Other
Purified
Bovine Thymus
N/A
EIA
MG
A3C301B

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