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Luteinizing hormone (LH)

Luteinizing hormone (LH) is a gonadotropic hormone that is produced by the pituitary gland and operates in conjunction with FSH to drive puberty, menstruation and fertility. A surge in LH levels triggers ovulation and the development of the corpus luteum in females, and in males it causes the Leydig cells to release testosterone.

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12 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
LH Recombinant
Antigen
Purified
Mammalian Cells
N/A
CLIA
UT
R01715
LH >= 98% Pure
Antigen
Purified
Human
N/A
CC
MG
A01687H
Goat anti Human LH
Polyclonal
Neat
Goat
N/A
RIA
ML
D10295G
MAb to LH Beta
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
E92120M
MAb to LH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAF07-412
MAb to LH Beta
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
E92402M
MAb to LH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAF07-226
MAb to LH
Monoclonal
Purified
Mouse
IgG2a,k
EIA, Pr
MG
MAF07-036
MAb to LH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAF07-037
MAb to LH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MDF07-037
MAb to LH, Beta
Monoclonal
Purified
Mouse
IgG
EIA, Pr, WB
MG
E86124M
Rabbit anti Bovine LH
Polyclonal
Neat
Rabbit
N/A
EIA, IHC, RIA, WB
ML
D01237R

Luteinizing hormone (LH)

High levels of luteinizing hormone can indicate a problem with infertility as the hormone directly impacts the reproductive system. In women, LH levels that are too high are often connected to polycystic ovary syndrome, which creates inappropriate testosterone levels. Some genetic conditions, like Turner syndrome or Klinefelter syndrome, can cause high levels of the hormone.

Low levels of luteinizing hormone can also cause infertility, because insufficient levels will limit the production of sperm or the ovulation process in women. LH deficiency almost always occurs in conjunction with follicle-stimulating hormone (FSH) deficiency because LH and FSH are secreted by the same pituitary gonadotrope cells. LH deficiency can manifest in females or males as delayed puberty, hypogonadism at any age, or reproductive abnormalities that can be dramatic or subtle.

Diagnosis

LH is composed of two noncovalently associated dissimilar amino acid chains, alpha and beta. The alpha chain is similar to that found in human thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG). LH diagnostic assays are useful to evaluate fertility issues, the function of reproductive organs (ovaries or testicles), or to detect ovulation. In children it can also be useful to evaluate early or delayed sexual maturation. The most sensitive LH assays on the market are monoclonal antibody based competitive-ELISAs. However, lateral flow devices using antibody sandwich-based formats are widely used for at-home ovulation tracking.

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