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Mycoplasma pneumoniae

Mycoplasma Pneumoniaeis a respiratory pathogen known to cause both upper and lower respiratory tract infections and is also referred to as “walking pneumonia.” According to the CDC, the prevalence of this infection is unknown, but it is estimated at roughly two million cases per year in the US. The spread of this pathogen is prevalent in crowded settings, young children, adolescents, immunocompromised individuals, and in patients recovering from other respiratory illnesses. Testing and surveillance are essential for identification and treatment with antibiotics in cases of mild or severe disease.

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20 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
Mycoplasma Pneumoniae Ag (fh)
Antigen
Partially Purified
Culture
N/A
N/A
MG
R14720
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
C01940M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr
MG
C01942M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG2a
EIA, IC, Pr
MG
C01939M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG2b
EIA, IC, Pr
MG
C01941M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG2a
EIA, IC, Pr
MG
C01943M
Mycoplasma Pneumoniae Ag
Antigen
Purified
Culture
N/A
CLIA, EIA, LF, WB
ML
R01701
Mycoplasma Pneumoniae Ag (fh)
Antigen
Purified
M. pneumoniae culture
N/A
EIA
ML
R02102
MAb to M. Pneumoniae P1
Monoclonal
Purified
Mouse
IgG2b
EIA, IFA, Pr
MG
C01787M
MAb to M. Pneumoniae P1
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, Pr
MG
C01788M
MAb to M. Pneumoniae P1
Monoclonal
Purified
Mouse
IgG2b
EIA, IFA, Pr
MG
C01789M
MAb to M. Pneumoniae P1
Monoclonal
Purified
Mouse
IgG2b
EIA, IFA, Pr
MG
C01790M
MAb to M. Pneumoniae P1
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C01791M
MAb to M. Pneumoniae P1
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C01792M
Rabbit A'mycoplasma Pneumoniae
Polyclonal
Purified
Rabbit
N/A
IFA
ML
B65511R
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, WB
MG
C01521M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, WB
MG
C01519M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, WB
MG
C01520M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, WB
MG
C01518M
MAb to Mycoplasma Pneumoniae
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, WB
MG
C01517M

Mycoplasma pneumoniae

M. pneumoniae can cause a host of symptoms such as primary atypical pneumonia, tracheobronchitis, and upper respiratory tract disease. Tracheobronchitis is most common in children with a reduced immune system, and up to 18% of infected children require hospitalization. Clinically, M. pneumoniae cannot be differentiated from pneumonia caused by other bacteria or viruses. A specific diagnosis is important because treatment of M. pneumoniae infection with β-lactam antibiotics is ineffective, whereas treatment with macrolides or tetracyclines can reduce the duration of the illness.

Adherence of M. pneumoniae to the respiratory epithelium is the first step in the infection process. This attachment process is a complex event that requires several adhesin proteins, such as P1, P30, and P116. The true incidence of M. pneumoniae associated infection is not clear as it difficult to diagnose in the early stages of infection.

To date, most commercial antibody detection assays for M. pneumoniae use partially purified lysates, although it has been demonstrated that a P1-enriched antigen increases the sensitivity and specificity of serologic diagnosis. Until recently, it has not been possible to develop a specific antigen for M. pneumoniae P1 due to an unusual UGA stop codon in the reading frame, leading to the premature termination of this protein in E. coli. M. pneumoniae P1 antigens are now readily available to enable the development of better performing EIA assays for both antigen and antibody detection specific to M. pneumoniae.

Diagnosis

The standard methods for detection of M. pneumoniae include culture, serology (conventionally this been limited to the complement fixation (CF) test, which predominantly measures IgM antibodies), and PCR. Immunoassays have been found to be more sensitive for the detection of acute infection than culture and have a sensitivity comparable to PCR. Traditionally, most commercial antibody detection assays for M. pneumoniae use partially purified lysates to detect specific IgG, IgM or IgA antibodies to distinguish between an acute or past infection. However, recombinant antigens have increased in popularity in recent years and research has demonstrated that a P1-enriched antigen increases the sensitivity and specificity of serologic diagnosis.

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