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Mycoplasma pneumoniae

Mycoplasma Pneumoniae is a respiratory pathogen known to cause both upper and lower respiratory tract infections and is also referred to as “walking pneumonia.” According to the CDC, the prevalence of this infection is unknown, but it is estimated at roughly two million cases per year in the US. The spread of this pathogen is prevalent in crowded settings, young children, adolescents, immunocompromised individuals, and in patients recovering from other respiratory illnesses. Testing and surveillance are essential for identification and treatment with antibiotics in cases of mild or severe disease.

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Mycoplasma pneumoniae Products (30)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog Buffer Immunogen Recombinant Description Notes SDS COA New Product Recommended Product Order a Sample
Mycoplasma Pneumoniae Ag (fh) Antigen Partially Purified Culture N/A EIA MG R14720 No View SDS View COA 0 Order a Sample
Mycoplasma Pneumoniae Ag (fh) Antigen Purified M. pneumoniae culture N/A EIA ML R02102 No View SDS View COA 0 Order a Sample
Mycoplasma Pneumoniae Ag Antigen Purified Culture N/A EIA,WB,LF,CLI ML R01701 No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG2a IC,Pr,EIA MG C01943M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG2b EIA,Pr MG C01942M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG2b EIA,Pr,IC MG C01941M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG2a EIA MG C01940M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG2a EIA,Pr,IC MG C01939M No View SDS View COA 0 Order a Sample
MAb to M. Pneumoniae P1 Monoclonal Purified Mouse IgG2a EIA,IFA,Pr MG C01792M No View SDS View COA 0 Order a Sample
MAb to M. Pneumoniae P1 Monoclonal Purified Mouse IgG2a EIA,IFA,Pr MG C01791M No View COA 0 Order a Sample
MAb to M. Pneumoniae P1 Monoclonal Purified Mouse IgG2b EIA,IFA,Pr MG C01790M No View SDS View COA 0 Order a Sample
MAb to M. Pneumoniae P1 Monoclonal Purified Mouse IgG2b EIA,IFA,Pr MG C01789M No View SDS View COA 0 Order a Sample
MAb to M. Pneumoniae P1 Monoclonal Purified Mouse IgG1 EIA,IFA,Pr MG C01788M No View SDS View COA 0 Order a Sample
MAb to M. Pneumoniae P1 Monoclonal Purified Mouse IgG2b EIA,IFA,Pr MG C01787M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C01521M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C01520M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C01519M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C01518M No View SDS View COA 0 Order a Sample
MAb to Mycoplasma Pneumoniae Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C01517M No View SDS View COA 0 Order a Sample
Rabbit A'mycoplasma Pneumoniae Polyclonal Purified Rabbit N/A IFA ML B65511R No View SDS View COA 0 Order a Sample
Mycoplasma pneumoniae Ag (FH) Antigen Purified M. pneumoniae culture N/A N/A ML BN1263 No View COA 0 Order a Sample
mAb to M. pneumoniae P1 Monoclonal Aff.Pur. Mouse IgG1,k EIA,LF MG BN1226 No View COA 0 Order a Sample
mAb to M. pneumoniae P1 Monoclonal Aff.Pur. Mouse IgM,k EIA,LF MG BN1225 No View COA 0 Order a Sample
M. pneumoniae P30 Rec. Ag Antigen Purified E. coli N/A EIA,LF MG BN1123 No View SDS View COA 0 Order a Sample
M. pneumoniae P1 Rec. Ag Antigen Purified E. coli N/A EIA,LF MG BN1122 No View SDS View COA 0 Order a Sample
M. pneumoniae P1 Rec. Ag Antigen Purified E. coli N/A EIA,LF MG BN1121 No View SDS View COA 0 Order a Sample
Mab to M. pneumoniae P1 Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1113 No View SDS View COA 0 Order a Sample
Mab to M. pneumoniae P1 Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1112 No View SDS View COA 0 Order a Sample
Mab to M. pneumoniae P1 Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1111 No View SDS View COA 0 Order a Sample
Mab to M. pneumoniae P1 Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1110 No View SDS View COA 0 Order a Sample

Mycoplasma pneumoniae

M. pneumoniae can cause a host of symptoms such as primary atypical pneumonia, tracheobronchitis, and upper respiratory tract disease. Tracheobronchitis is most common in children with a reduced immune system, and up to 18% of infected children require hospitalization. Clinically, M. pneumoniae cannot be differentiated from pneumonia caused by other bacteria or viruses. A specific diagnosis is important because treatment of M. pneumoniae infection with β-lactam antibiotics is ineffective, whereas treatment with macrolides or tetracyclines can reduce the duration of the illness.

Adherence of M. pneumoniae to the respiratory epithelium is the first step in the infection process. This attachment process is a complex event that requires several adhesin proteins, such as P1, P30, and P116. The true incidence of M. pneumoniae associated infection is not clear as it difficult to diagnose in the early stages of infection.

To date, most commercial antibody detection assays for M. pneumoniae use partially purified lysates, although it has been demonstrated that a P1-enriched antigen increases the sensitivity and specificity of serologic diagnosis. Until recently, it has not been possible to develop a specific antigen for M. pneumoniae P1 due to an unusual UGA stop codon in the reading frame, leading to the premature termination of this protein in E. coli. M. pneumoniae P1 antigens are now readily available to enable the development of better performing EIA assays for both antigen and antibody detection specific to M. pneumoniae.

Diagnosis

The standard methods for detection of M. pneumoniae include culture, serology (conventionally this been limited to the complement fixation (CF) test, which predominantly measures IgM antibodies), and PCR. Immunoassays have been found to be more sensitive for the detection of acute infection than culture and have a sensitivity comparable to PCR. Traditionally, most commercial antibody detection assays for M. pneumoniae use partially purified lysates to detect specific IgG, IgM or IgA antibodies to distinguish between an acute or past infection. However, recombinant antigens have increased in popularity in recent years and research has demonstrated that a P1-enriched antigen increases the sensitivity and specificity of serologic diagnosis.

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