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HIV

Human immunodeficiency virus (HIV) is a sexually transmitted lentivirus that causes acquired immunodeficiency syndrome (AIDS), a condition that leads to progressive failure of the immune system. It is spread through contact with blood, semen, pre-seminal fluid, rectal fluids, vaginal fluids, or breast milk of a person with HIV. If left untreated, it is almost always fatal.

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HIV Products (70)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog Buffer Immunogen Recombinant Description Notes SDS COA New Product Recommended Product Order a Sample
Mab to HIV-1 P24 Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1046 No View SDS View COA 0 Order a Sample
Mab to HIV-1 P24 Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1045 No View SDS View COA 0 Order a Sample
HIV-1 gp41, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1030 No View SDS View COA 0 Order a Sample
HIV-2 gp36, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1029 No View SDS View COA 0 Order a Sample
HIV-2 gp36, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1028 No View SDS View COA 0 Order a Sample
HIV-2 gp36, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1027 No View SDS View COA 0 Order a Sample
HIV-2 gp36, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1026 No View SDS View COA 0 Order a Sample
HIV-2 gp36, Recombinant Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1025 No View SDS View COA 0 Order a Sample
HIV-1 gp41, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1024 No View SDS View COA 0 Order a Sample
HIV-1(Group O) gp41, Rec.Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1023 No View SDS View COA 0 Order a Sample
HIV-1 gp41, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1022 No View SDS View COA 0 Order a Sample
HIV-2 gp36, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1021 No View SDS View COA 0 Order a Sample
HIV-1 gp41, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1020 No View SDS View COA 0 Order a Sample
HIV-1(Group O) gp41, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1019 No View SDS View COA 0 Order a Sample
HIV-1 P24, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1018 No View SDS View COA 0 Order a Sample
HIV-1 p24 Recombinant Antigen Purified E. coli N/A EIA,WB MG R01627 No View SDS View COA 0 Order a Sample
HIV-2 gp36, Recombinant Antigen Purified Pichia pastoris N/A WB,EIA MG VTI360 No View SDS View COA 0 Order a Sample
HIV-1 p24, Recombinant Antigen Purified Pichia pastoris N/A WB,EIA MG VTI340 No View SDS View COA 0 Order a Sample
HIV-2 Env Ag Recomb. Antigen Purified E. coli N/A EIA,WB MG R8A114 No View SDS View COA 0 Order a Sample
HIV-1 Env Ag Recomb. Antigen Purified E. coli N/A EIA,WB MG R8A113 No View SDS View COA 0 Order a Sample
HIV-1 nef antigen Recomb Antigen Purified E. coli N/A EIA,WB MG R8A112 No View SDS View COA 0 Order a Sample
HIV-1 gag p24 Ag Recomb. IIIb Antigen Purified E. coli N/A EIA,WB MG R8A111 No View SDS View COA 0 Order a Sample
HIV-2 gp36 Recomb. Antigen Purified E. coli N/A EIA MG R65911 No View SDS View COA 0 Order a Sample
HIV-1 gp41 env. Recomb Antigen Purified E. coli N/A EIA MG R65908 No View SDS View COA 0 Order a Sample
HIV-1 Ag Recombinant Antigen Purified E. coli N/A EIA,WB MG R18550 No View SDS View COA 0 Order a Sample
HIV-2 env. gp36, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18410 No View SDS View COA 0 Order a Sample
HIV-1 gp41, Recombinant Antigen Purified, Liquid E. coli N/A WB,EIA MG R01799 No View SDS View COA 0 Order a Sample
HIV-2 gp36 Recombinant Antigen Purified E. coli N/A EIA,LF MG R01634 No View SDS View COA 0 Order a Sample
HIV-1 gp41 Recombinant Antigen Purified E. coli N/A EIA,LF MG R01633 No View COA 0 Order a Sample
HIV Chimeric Recombinant Antigen Purified E. coli N/A LF,Pr MG R01631 No View SDS View COA 0 Order a Sample
HIV Chimeric Recomb. Antigen Purified E. coli N/A LF,Pr MG R01626 No View SDS View COA 0 Order a Sample
HIV Chimeric Recomb. Antigen Purified E. coli N/A LF,Pr,EIA MG R01625 No View SDS View COA 0 Order a Sample
HIV-1 Ag, Recombinant Antigen Purified E. coli N/A EIA,WB MG R01593 No View SDS View COA 0 Order a Sample
HIV gp41/O Group Gp41/gp36 Antigen Purified E. coli N/A EIA MG R01547 No View SDS View COA 0 Order a Sample
HIV-1 gp160, Recombinant Antigen Purified E. coli N/A EIA MG R01532 No View SDS View COA 0 Order a Sample
HIV-1 Integrase p31, Recomb. Antigen Purified E. coli N/A EIA,LF,WB MG R01488 No View SDS View COA 0 Order a Sample
HIV-1 gp41 Ag, Type O, Recomb. Antigen Purified E. coli N/A EIA,LF,WB MG R01454 No View SDS View COA 0 Order a Sample
HIV-1 Gp120 (v3 Loop), Recomb. Antigen Purified E. coli N/A EIA MG R01276 No View SDS View COA 0 Order a Sample
MAb to HIV-2 Gp36 Monoclonal Purified Mouse IgG2a EIA,WB MG C8A401H No View SDS View COA 0 Order a Sample
MAb to HIV-1 gp41 Monoclonal Purified Mouse IgG1 EIA,WB MG C8A015M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p17 Monoclonal Purified Mouse IgG1 EIA,WB,IHC,IP MG C8A014M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1 EIA,IFA,IHC,Pr,WB,LF MG C65941M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal FITC Mouse IgG1 EIA,IFA,IHC,WB MG C65941F No View SDS View COA 0 Order a Sample
MAb to HIV-1 gp41 Monoclonal Purified Mouse IgG2 WB MG C65911M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1 EIA,Pr,LF,CLI MG C65690M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1 EIA,Pr MG C65499M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1 EIA,IFA MG C65489M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1 EIA,IFA MG C65479M No View SDS View COA 0 Order a Sample
MAb to HIV-2, gp36 Monoclonal Purified Mouse IgG1 EIA MG C18386M No View SDS View COA 0 Order a Sample
MAb to HIV-1(pnd Of Mn Strain) Monoclonal Purified Mouse IgG1 EIA,LF,WB MG C18111M No View SDS View COA 0 Order a Sample
MAb to HIV-1 P24 Monoclonal Purified Mouse IgG1 EIA,Pr MG C11999M No View SDS View COA 0 Order a Sample
MAb to HIV-1 P24 Monoclonal Purified Mouse IgG1 EIA,Pr MG C11998M No View SDS View COA 0 Order a Sample
Chicken anti HIV-1 p24 Polyclonal Aff.Pur. Chicken N/A EIA,Pr MG C01848C No View SDS View COA 0 Order a Sample
Chicken anti HIV-1 p24 Polyclonal Aff.Pur. Chicken N/A EIA,Pr MG C01847C No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1,k EIA,Pr MG C01657M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1,k Pr,EIA MG C01656M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1,k EIA,Pr MG C01655M No View SDS View COA 0 Order a Sample
MAb to HIV-1 p24 Monoclonal Purified Mouse IgG1,k LF,EIA,WB,CLI MG C01653M No View SDS View COA 0 Order a Sample
MAb to HIV 1/2 P24 Monoclonal Purified Mouse IgG1,k EIA,WB MG C01577M No View SDS View COA 0 Order a Sample
MAb to HIV 1/2 P24 Monoclonal Purified Mouse IgG1,k EIA,WB MG C01576M No View COA 0 Order a Sample
Goat anti HIV-1 Gp41 Polyclonal Purified Goat N/A WB ML B65971G No View SDS View COA 0 Order a Sample
Goat anti HIV-1 Gp120 Polyclonal HRP Goat N/A EIA,WB ML B65961P No View SDS View COA 0 Order a Sample
Goat anti HIV-1 Gp120 Polyclonal Purified Goat N/A EIA,WB ML B65961G No View SDS View COA 0 Order a Sample
Goat anti HIV-1 Gp120 Polyclonal Biotin Goat N/A EIA,WB ML B65961B No View SDS View COA 0 Order a Sample
Goat anti HIV-1 P24 Polyclonal HRP Goat N/A EIA,WB ML B65951P No View SDS View COA 0 Order a Sample
Goat anti HIV-1 P24 Polyclonal Purified Goat N/A EIA,IFA,WB ML B65951G No View SDS View COA 0 Order a Sample
Goat anti HIV-1 P24 Polyclonal FITC Goat N/A EIA,IFA,WB ML B65951F No View SDS View COA 0 Order a Sample
Goat anti HIV-1 P24 Polyclonal Biotin Goat N/A EIA,WB ML B65951B No View SDS View COA 0 Order a Sample
Goat anti HIV-1 Polyclonal Purified Goat N/A IFA ML B65875G No View SDS View COA 0 Order a Sample
Goat anti HIV-1 Polyclonal HRP Goat N/A EIA ML B65873G No View SDS View COA 0 Order a Sample

Human Immunodeficiency (HIV)

There are two major types of HIV, type 1 (HIV-1) and type 2 (HIV-2). HIV-1 viruses are further divided into groups M, N, O, P. Group M viruses are the most common group and are predominately responsible for the AIDS pandemic. Group M is further subdivided into clades based on their genetic sequences, which tend to concentrate within specific geographic regions. The clade that an individual becomes infected with can be a major factor in the rate of progression to AIDS; specifically clades C, D and G are 8 times more likely to develop AIDS.

HIV-2 is mostly found in West Africa and it is also divided into groups (A to H). It is less easily transmitted than HIV-1 and the time between infection and symptoms tends to be longer. Despite its relative geographic confinement, HIV-2 should be considered in all patients exhibiting symptoms of HIV.

HIV is divided into three main stages:

Acute Retroviral Syndrome: Early symptoms of HIV are defined as acute retroviral syndrome and they appear 3-6 weeks after infection and can easily be confused with the symptoms of the flu or other milder diseases. As a result, most infections remain undiagnosed until they progress to more advanced stages.

Clinical Latency (inactivity or dormancy): This period is sometimes called asymptomatic HIV infection or chronic HIV infection. During this phase HIV is active but reproduces at very low levels. People who are on antiretroviral therapy may live with clinical latency for several decades. Toward the middle and end of this period, the viral load begins to rise and the CD4+ cell count begins to drop. The World Health Organization (WHO) sub-classifies this period into three stages based on the CD4+ cell count of the individual:

STAGE 1: the CD4+ cell count is at least 500 cells per microliter

STAGE 2: the CD4+ cell count is 350 to 499

STAGE 3 (advanced HIV disease, or AHD): The CD4+ cell count is 200 to 349

AIDS (Acquired Immunodeficiency Syndrome): This is the stage of infection that occurs when the immune system is badly damaged and an infected individual become vulnerable to opportunistic illnesses. The CD4+ cell count is less than 200 or the percent of CD4+ cells is less than 15% of all lymphocytes. Without treatment, people who are diagnosed with AIDS typically survive about 3 years. Once a dangerous opportunistic illness is acquired, life expectancy without treatment falls to about 1 year.

Diagnosis

Laboratory diagnosis is the only way to confirm an HIV infection and there are specific serologic markers that can be detected early in the course of an infection:

  • HIV RNA: detectable by molecular methods, 11 days from the time of HIV infection
  • HIV-1 P24 ANTIGEN: detectable 16 days from the time of infection
  • HIV ANTIBODIES: detectable 22 days from the time of infection.

During the early infection stage (acute retroviral syndrome) the flu-like symptoms are accompanied by a burst of viral replication that can be detected in the blood. The detection of p24 antigen (viral capsid protein) is directly correlated to the amount of virus (viral load) circulating in the infected individual.

Antibodies against specific HIV proteins and glycoproteins (e.g. p24, gp41, gp120) are produced between 2-8 weeks after infection and remain detectable in the blood thereafter.

The screening test most widely used to detect exposure to HIV is the “HIV Antibody Test”. The first test was approved in 1985 by the FDA and it still remains one of the WHO recommended HIV diagnostics. Advances in technologies and critical reagents have enabled the development of new generation HIV Antibody Tests, which are able to detect an infected individual earlier and with greater accuracy. The 4th generation HIV Antibody Test is capable of diagnosing an HIV infection 3-4 weeks after transmission by simultaneously detecting both HIV antibody and p24 antigen. In addition, many of these tests can also distinguish between acute and established HIV infections, as well as detect antibodies to HIV groups M and O, and HIV-2.

The commercial HIV diagnostic testing market has expanded to include several testing formats such as Western blot, immunofluorescence (IFA), and lateral flow as well as self-collection sample types such as saliva, and urine. Regardless of the type of screening test used, a positive result requires follow up with a second test to confirm a diagnosis of HIV.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!


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