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Hepatitis B

Hepatitis B (HBV) is virus that infects the liver and most adults (95%) who are infected are able to quickly recover however some have long-lasting illness that can lead to liver disease, liver cancer and death. In babies and young children, HBV can also develop into a chronic infection leading to liver cirrhosis or liver cancer later in life. 350 million people worldwide are infected with HBV and it is the cause of 620,000 deaths each year.

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80 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
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Hepatitis B Core Virus (HBcAg) (183 a.a.) Recombinant
Purified
Pichia pastoris
N/A
EIA
MG
VTI610
Hepatitis B Surface Antigen (HBsAg) (adr) Recombinant
Purified
S. cerevisiae
N/A
EIA
MG
R86783
Hepatitis B Surface Antigen (HBsAg) (ayw) Recombinant
Purified
S. cerevisiae
N/A
EIA
MG
R86870
Hepatitis B Surface Antigen (HBsAg) (adw) Recombinant
Purified
S. cerevisiae
N/A
EIA
MG
R86872
Hepatitis B Core Antigen (HBcAg) (a.a. 1-183) 18kDa, Recombinant
Purified
E. coli
N/A
LF
MG
R8A120
Hepatitis B Core Antigen (HBcAg) (a.a. 1-144) 14kDa, Recombinant
Purified
E. coli
N/A
WB
MG
R8A100
Hepatitis B Presurface S1 (108 a.a.) 13.5kDa, Recombinant
Purified
E. coli
N/A
WB
MG
R65913
Hepatitis B Core Antigen (HBcAg) (184 a.a.) 19kDa, Recombinant
Purified
E. coli
N/A
WB
MG
R65914
Hepatitis B 'e' Antigen (HBeAg) (160 a.a.) 17kDa, Recombinant
Purified
E. coli
N/A
WB
MG
R65915
Hepatitis B 'e' Antigen (HBeAg) Recombinant
Purified
E. coli
N/A
WB
MG
R18915
Hepatitis B Surface Antigen (HBsAg) (adw) Recombinant
Purified
Pichia pastoris
N/A
WB
MG
R18560
Hepatitis B Surface Antigen (HBsAg) (adr) Recombinant
Purified
CHO Cells
N/A
CLI
MG
R01652
Hepatitis B Presurface S1+S2
Purified
E. coli
N/A
EIA
MG
R01579
Hepatitis B Presurface S2
Purified
E. coli
N/A
EIA
MG
R01580
Hepatitis B Surface Antigen (HBsAg) (ad)
Purified
Human
N/A
EIA
MG
R01507
Hepatitis B Surface Antigen (HBsAg) (ay)
Purified
Human
N/A
EIA
MG
R01508
Hepatitis B Surface Antigen (HBsAg) (adw) Recombinant
Purified
Pichia pastoris
N/A
EIA
MG
R01403
Hepatitis B Surface Antigen (HBsAg) (ay) Recombinant
Purified
S. cerevisiae
N/A
WB
MG
R01290
Hepatitis B 'e' Antigen (HBeAg) Recombinant
Purified
E. coli
N/A
EIA
MG
R01401
Hepatitis B Surface Antigen (HBsAg) (ad) Recombinant
Purified
S. cerevisiae
N/A
WB
MG
R01289
Hepatitis B Surface Antigen (HBsAg)
Purified
Mouse
IgG1,k
Pr
MG
MAV18-511
Hepatitis B Surface Antigen (HBsAg) (ay)
Purified
Mouse
IgG2a,k
Pr
MG
MAV18-004
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG2b
RIA
MG
C92100M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2b
Pr
MG
C86843M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG1
Pr
MG
C86743M
Hepatitis B Surface Antigen (HBsAg) (ayw)
HRP
Mouse
IgG1
EIA
MG
C86600P
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2b
Pr
MG
C86534M
Hepatitis B Surface Antigen (HBsAg)
Purified
Mouse
IgG1
Pr
MG
C86401M
Hepatitis B Surface Antigen (HBsAg)
HRP
Mouse
IgG1
EIA
MG
C86401P
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2b
Pr
MG
C86334M
Hepatitis B Core Antigen (HBcAg)
Purified
Mouse
IgG2a
WB
MG
C86340M
Hepatitis B Surface Antigen (HBsAg) (ayw)
Purified
Mouse
IgG1
Pr
MG
C86322M
Hepatitis B Core Antigen (HBcAg)
Purified
Mouse
IgG2a
WB
MG
C86317M
Hepatitis B Surface Antigen (HBsAg) (ayw)
Purified
Mouse
IgG1
Pr
MG
C86312M
Hepatitis B Surface Antigen (HBsAg)
Purified
Mouse
IgG2a
Pr
MG
C86303M
Hepatitis B Core Antigen (HBcAg) (ayw) (a.a. 130-140)
Dil.Ascites
Mouse
IgG2a
IB
MG
C8A038M
Hepatitis B Core Antigen (HBcAg) (ayw) (a.a. 138-145)
Dil.Ascites
Mouse
IgG2b
IB
MG
C8A037M
Hepatitis B Core Antigen (HBcAg) (ayw) (a.a. 1-10)
Dil.Ascites
Mouse
IgG2a
IB
MG
C8A036M
Hepatitis B Core Antigen (HBcAg) (ayw) (~80 a.a.)
Dil.Ascites
Mouse
IgG2b
IB
MG
C8A035M
Hepatitis B Core Antigen (HBcAg) (ayw) (a.a. 135-140)
Purified
Mouse
IgG2b
IB
MG
C8A034M
Hepatitis B Core Antigen (HBcAg) (ayw) (a.a. 135-140)
Biotin
Mouse
IgG2b
IB
MG
C8A034B
Hepatitis B Core Antigen (HBcAg) (ayw) (a.a. 70-80)
Purified
Mouse
IgG2a
WB
MG
C8A033M
Hepatitis B Presurface Antigen (adw) (a.a. 132-137)
Purified
Mouse
IgG1
WB
MG
C8A031M
Hepatitis B Surface Antigen (HBsAg) (adw/ayw)
KLH
Mouse
IgG1
IFA
MG
C8A032M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2a
Pr
MG
C65814M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2a
Pr
MG
C65318M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG1
Pr
MG
C65218M
Hepatitis B Surface Antigen (HBsAg) (ay)
Purified
Mouse
IgG1
RIA
MG
C45704M
Hepatitis B Surface Antigen (HBsAg) (ad)
Purified
Mouse
IgG1
RIA
MG
C45098M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG1
RIA
MG
C45100M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2a
Pr
MG
C31170M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG1
Pr
MG
C18212M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG1
Pr
MG
C18286M
Hepatitis B Surface Antigen (HBsAg)
Purified
Mouse
IgG1
EIA
MG
C01815M
Hepatitis B X Antigen
Purified
Mouse
IgG2a
WB
MG
C01767M
Hepatitis B X Antigen
Purified
Mouse
IgG1
WB
MG
C01768M
Hepatitis B X Antigen
Purified
Mouse
IgG1
WB
MG
C01766M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2a
LF
MG
C01693M
Hepatitis B 'e' Antigen (HBeAg)
Purified
Mouse
IgG2b
LF
MG
C01692M
Hepatitis B Core Antigen (HBcAg)
Purified
Mouse
IgG2a
Pr
MG
C01557M
Hepatitis B Core Antigen (HBcAg)
Purified
Mouse
IgG2a
Pr
MG
C01558M
Hepatitis B Core Antigen (HBcAg)
Purified
Mouse
IgG2b
Pr
MG
C01556M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG2b,l
Pr
MG
C01465M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG1,k
LF
MG
C01457M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG1
Pr
MG
C01458M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG2a,k
LAT
MG
C01455M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG1,k
LF
MG
C01456M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG1
Pr
MG
C01250M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG2a
Pr
MG
C01248M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG2a
Pr
MG
C01249M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG2a
Pr
MG
C01246M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Mouse
IgG2a
Pr
MG
C01247M
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Biotin
Rabbit
N/A
EIA
ML
B65811B
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
FITC
Rabbit
N/A
IFA
ML
B65811F
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
HRP
Rabbit
N/A
Pr
ML
B65811P
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Rabbit
N/A
EIA
ML
B65811R
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
FITC
Goat
N/A
IEP
ML
B65803F
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
HRP
Goat
N/A
EIA
ML
B65804P
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Biotin
Goat
N/A
IEP
ML
B65807B
Hepatitis B Surface Antigen (HBsAg) (ad/ay)
Purified
Goat
N/A
EIA
ML
B65180G

Hepatitis B (HBV)

Hepatitis is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes presented on its envelope proteins, and into eight genotypes (A-H) according to overall nucleotide sequence variation of the genome. The subtypes are associated geographic distribution, ethnicity, and clinical outcomes such as response to treatment. East Asia and Sub-Saharan Africa have the highest rates of BV infection (up to 15% of the adult population) and infection around the time of birth is the most frequent way HBV is acquired in areas of the world where the disease is common, as mothers pass the infection to their babies during childbirth. Overall, HBV is spread when blood, semen, or other body fluid infected with the hepatitis B virus enters the body of someone who is not infected which can happen through sexual contact, sharing needles, and blood transfusion. The likelihood of an infected individual resolving an acute HBV infection depends on their age and the strength of their initial immune response.

Diagnosis

Serologic testing of HBV involves a panel of several HBV-specific markers: HBV surface antigen (HBsAg), HBV core antigen (HBcAg) and HBV “e” antigen (HBeAg). These markers help distinguish whether a patient is susceptible to primary infection, immune as a result of a resolved infection, immune as a result of vaccination, acutely infected, or chronically infected. During acute infection, the appearance of virologic markers develop in a typical pattern. The first serologic marker to appear within 1-12 weeks of an acute infection is HBsAg, along with pre-S1 and pre-S2 antigens. Then, HBeAg becomes detectable which indicates that a person is highly infectious and clinical symptoms begin to develop. IgM antibody to HBcAg (anti-HBc) appears next and remains present for up to 4 months, after which only IgG antibody to HBcAg remains and persists indefinitely. Anti-HBe appears after anti-HBc and its presence correlates to a decreased infectivity. Acute hepatitis patients who maintain a constant serum HBsAg concentration or whose serum HBeAg persists for 8-10 weeks after symptoms have resolved, are at risk of developing chronic liver disease.

Type of HBV assays include:

Anti-HBc, IgM or Total

A positive anti-HBc IgM indicates a recent, acute infection (within the past 6 months). A positive anti-HBc Total is a non-specific assay used to detect acute, chronic, or resolved HBV infection. It may be used in pre-vaccination testing to determine previous exposure to an HBV infection, but it is not a marker of immunity.

HBsAg

Used to screen for and detect HBV infections, either recent or chronic. HBsAg is the earliest indicator of acute Hepatitis B and frequently identifies infected people before symptoms appear. HBsAg is the most widely used diagnostic and blood screening Hepatitis B test worldwide.

Anti-HBs

Used to determine immunity status. Used to detect previous exposure to HBV or to establish vaccination status. Subtypes adw, ady, and adr are each found in different geographic regions of the world. In Japan, China, and Southeast Asia, the r determinant predominates and in Europe, the US, Africa, India, Australia, and Oceania, the w determinant predominates. The y determinant is found in Africa and in Australia aborigines. (WHO, 2014)

HBeAg

A marker of a high degree of infectivity as it correlates with a high level of viral replication. Primarily used to monitor the effectiveness of treatment for chronic sufferers. However, some strains of HBV do not make “e” antigen, especially those found in the Middle East and Asia.

Anti-HBe

Used to diagnose and monitor the treatment of a chronic infection. Its presence suggests a low viral titer and a low degree of infectivity in persons with a chronic infection.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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