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Hepatitis B (HBV)

Hepatitis B (HBV) is virus that infects the liver and most adults (95%) who are infected are able to quickly recover however some have long-lasting illness that can lead to liver disease, liver cancer and death. In babies and young children, HBV can also develop into a chronic infection leading to liver cirrhosis or liver cancer later in life. 350 million people worldwide are infected with HBV and it is the cause of 620,000 deaths each year.

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Clear Results
84 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
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HBsAg (adr) Recombinant
Antigen
Purified
CHO Cells
N/A
N/A
MG
R01652
Hep B Core antigen Recomb
Antigen
Purified
E. coli
N/A
EIA
MG
R8A100
Hepatitis B Core Ag Recomb
Antigen
Purified
E. coli
N/A
EIA, LF, WB
MG
R8A120
MAb to HBsAg (ad)
Monoclonal
Purified
Mouse
IgG1
EIA, IP, RIA
MG
C45098M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG1
EIA, IP, RIA
MG
C45100M
MAb to HBsAg
Monoclonal
HRP
Mouse
IgG1
EIA
MG
C86401P
HB Pre-S1+S2
Antigen
Purified
E. coli
N/A
EIA
MG
R01579
HB Pre-S2
Antigen
Purified
E. coli
N/A
EIA
MG
R01580
MAb to HBsAg (ay)
Monoclonal
Purified
Mouse
IgG1
EIA, IP, RIA
MG
C45704M
MAb to HBsAg
Monoclonal
Purified
Mouse
IgG1
EIA
MG
C01815M
HB pre-S1 Ag 13.5 kDa Recomb.
Antigen
Purified
E. coli
N/A
EIA, WB
MG
R65913
Hb Core Ag, 19 kDa Recomb.
Antigen
Purified
E. coli
N/A
EIA
MG
R65914
Hepatitis B Core Virus, Recomb
Antigen
Purified
Pichia pastoris
N/A
EIA, WB
MG
VTI610
MAb to HBx
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01766M
MAb to HBx
Monoclonal
Purified
Mouse
IgG2a
EIA, WB
MG
C01767M
MAb to HBx
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C01768M
MAb to HBeAg
Monoclonal
Purified
Mouse
IgG2b
EIA, LF, Pr
MG
C01692M
MAb to HBeAg
Monoclonal
Purified
Mouse
IgG2a
EIA, LF, Pr
MG
C01693M
Goat A' HBsAg (ad/ay)
Polyclonal
Biotin
Goat
N/A
EIA, IEP
ML
B65807B
Rabbit anti HBsAg (ad/ay)
Polyclonal
FITC
Rabbit
N/A
IFA
ML
B65811F
Rabbit anti HBsAg (ad/ay)
Polyclonal
Biotin
Rabbit
N/A
EIA
ML
B65811B
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01246M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01249M
MAb to Hepatitis B Virus Core
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr
MG
C01556M
MAb to Hepatitis B Virus Core
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01558M
MAb to Hepatitis B 'e' antigen
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
C65218M
MAb to Hepatitis B 'e' antigen
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C65318M
MAb to Hepatitis B 'e' antigen
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C65814M
HBsAg (ayw) Recombinant
Antigen
Purified
S. cerevisiae
N/A
EIA, WB
MG
R01290
Rabbit anti HBsAg (ad/ay)
Polyclonal
HRP
Rabbit
N/A
EIA, Pr
ML
B65811P
Goat A' HBsAg (ad/ay)
Polyclonal
HRP
Goat
N/A
EIA
ML
B65804P
Rabbit anti HBsAg (ad/ay)
Polyclonal
Purified
Rabbit
N/A
EIA
ML
B65811R
Goat A'HBsAg (ad/ay)
Polyclonal
Purified
Goat
N/A
EIA
ML
B65180G
MAb to HBcAg (ayw)
Monoclonal
Dil.Ascites
Mouse
IgG2b
EIA, IB, IHC, IP, WB
MG
C8A037M
MAb to HBcAg (ayw)
Monoclonal
Dil.Ascites
Mouse
IgG2a
EIA, IB, IHC, IP, WB
MG
C8A038M
MAb to HBsAg (adw/ayw)
Monoclonal
KLH
Mouse
IgG1
EIA, IFA
MG
C8A032M
MAb to HBcAg (ayw)
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, WB
MG
C8A033M
MAb to Hepatitis B Presurface
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, WB
MG
C8A031M
MAb to HBcAg (ayw)
Monoclonal
Dil.Ascites
Mouse
IgG2b
EIA, IB, IHC, IP, WB
MG
C8A035M
MAb to Hepatitis B Core (ayw)
Monoclonal
Biotin
Mouse
IgG2b
EIA, IB, IP, WB
MG
C8A034B
Hep. B Ag "e" Epitope Recomb
Antigen, Other
Purified
E. coli
N/A
EIA, WB
MG
R65915
Hepatitis B Ag 'e' Recomb
Antigen
Purified
E. coli
N/A
EIA, WB
MG
R18915
HBsAg (ayw) Recomb.
Antigen
Purified
S. cerevisiae
N/A
EIA
MG
R86870
HBsAg (adw) Recombinant
Antigen
Purified
S. cerevisiae
N/A
EIA
MG
R86872
MAb to Hepatitis B 'e' antigen
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr
MG
C86534M
MAb to HBsAg (ayw)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
C86313M
Goat A' HBsAg (ad/ay)
Polyclonal
FITC
Goat
N/A
EIA, IEP
ML
B65803F
Horse anti HBsAg (ad/ay)
Antigen
Aff.Pur.
Horse
N/A
EIA, IFA, IHC(f), IP
MG
B03504C
MAb to HBcAg (ayw) (a.a.1-10)
Monoclonal
Dil.Ascites
Mouse
IgG2a
EIA, IB, IHC, IP, WB
MG
C8A036M
MAb to Hepatitis B Core (ayw)
Monoclonal
Purified
Mouse
IgG2b
EIA, IB, IP, WB
MG
C8A034M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG2b
EIA, RIA
MG
C92100M
HBsAg (adw) Recombinant
Antigen
Purified
Pichia pastoris
N/A
EIA, WB
MG
R18560
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG1
EIA, LF, Pr
MG
C18212M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG1
EIA, LF, Pr
MG
C18286M
MAb to HBeAg
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr
MG
C01549M
MAb to HBeAg
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01548M
Hepatitis B Surface Ag (ad)
Antigen
Purified
Human
N/A
EIA
MG
R01507
MAb to Hepatitis B Virus Core
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01557M
HBsAg (adw) Recombinant
Antigen
Purified
S. cerevisiae
N/A
EIA, WB
MG
R01289
MAb to HBsAg
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAV18-511
MAb to Hepatitis B 'e' antigen
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
C86743M
HBsAg (adw) Recombinant
Antigen
Purified
Pichia pastoris
N/A
EIA
MG
R01403
MAb to Hepatitis B 'e' antigen
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr
MG
C86334M
MAb to HBsAg (ayw)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
C86322M
MAb to HBsAg (ayw)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
C86312M
MAb to HBsAg (ay)
Monoclonal
Purified
Mouse
IgG2a,k
EIA, Pr
MG
MAV18-004
MAb to Hepatitis B 'e' antigen
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr
MG
C86843M
MAb to HBsAg
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
C86401M
MAb to HBcAg
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr, WB
MG
C86317M
MAb to Hepatitis B 'e' Ag
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C31170M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG2b,l
EIA, LF, Pr
MG
C01465M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
C01250M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG1,k
EIA, LF
MG
C01456M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG2a,k
EIA, LAT, LF
MG
C01455M
MAb to HBsAg
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C86303M
MAb to HBcAg
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr, WB
MG
C86340M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG1,k
EIA, LF, Pr
MG
C01457M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01247M
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr
MG
C01248M
HBsAg (adr) Recomb.
Antigen
Purified
S. cerevisiae
N/A
EIA
MG
R86783
Hepatitis B 'e' Ag, Recomb.
Antigen
Purified
E. coli
N/A
EIA
MG
R01401
MAb to HBsAg (ayw)
Monoclonal
HRP
Mouse
IgG1
EIA
MG
C86600P
MAb to HBsAg (ad/ay)
Monoclonal
Purified
Mouse
IgG1
EIA, LF, Pr
MG
C01458M
Hepatitis B Surface Ag (ay)
Antigen
Purified
Human
N/A
EIA
MG
R01508

Hepatitis B (HBV)

Hepatitis is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes presented on its envelope proteins, and into eight genotypes (A-H) according to overall nucleotide sequence variation of the genome. The subtypes are associated geographic distribution, ethnicity, and clinical outcomes such as response to treatment. East Asia and Sub-Saharan Africa have the highest rates of BV infection (up to 15% of the adult population) and infection around the time of birth is the most frequent way HBV is acquired in areas of the world where the disease is common, as mothers pass the infection to their babies during childbirth. Overall, HBV is spread when blood, semen, or other body fluid infected with the hepatitis B virus enters the body of someone who is not infected which can happen through sexual contact, sharing needles, and blood transfusion. The likelihood of an infected individual resolving an acute HBV infection depends on their age and the strength of their initial immune response.

Diagnosis

Serologic testing of HBV involves a panel of several HBV-specific markers: HBV surface antigen (HBsAg), HBV core antigen (HBcAg) and HBV “e” antigen (HBeAg). These markers help distinguish whether a patient is susceptible to primary infection, immune as a result of a resolved infection, immune as a result of vaccination, acutely infected, or chronically infected. During acute infection, the appearance of virologic markers develop in a typical pattern. The first serologic marker to appear within 1-12 weeks of an acute infection is HBsAg, along with pre-S1 and pre-S2 antigens. Then, HBeAg becomes detectable which indicates that a person is highly infectious and clinical symptoms begin to develop. IgM antibody to HBcAg (anti-HBc) appears next and remains present for up to 4 months, after which only IgG antibody to HBcAg remains and persists indefinitely. Anti-HBe appears after anti-HBc and its presence correlates to a decreased infectivity. Acute hepatitis patients who maintain a constant serum HBsAg concentration or whose serum HBeAg persists for 8-10 weeks after symptoms have resolved, are at risk of developing chronic liver disease.

Type of HBV assays include:

Anti-HBc, IgM or Total

A positive anti-HBc IgM indicates a recent, acute infection (within the past 6 months). A positive anti-HBc Total is a non-specific assay used to detect acute, chronic, or resolved HBV infection. It may be used in pre-vaccination testing to determine previous exposure to an HBV infection, but it is not a marker of immunity.

HBsAg

Used to screen for and detect HBV infections, either recent or chronic. HBsAg is the earliest indicator of acute Hepatitis B and frequently identifies infected people before symptoms appear. HBsAg is the most widely used diagnostic and blood screening Hepatitis B test worldwide.

Anti-HBs

Used to determine immunity status. Used to detect previous exposure to HBV or to establish vaccination status. Subtypes adw, ady, and adr are each found in different geographic regions of the world. In Japan, China, and Southeast Asia, the r determinant predominates and in Europe, the US, Africa, India, Australia, and Oceania, the w determinant predominates. The y determinant is found in Africa and in Australia aborigines. (WHO, 2014)

HBeAg

A marker of a high degree of infectivity as it correlates with a high level of viral replication. Primarily used to monitor the effectiveness of treatment for chronic sufferers. However, some strains of HBV do not make “e” antigen, especially those found in the Middle East and Asia.

Anti-HBe

Used to diagnose and monitor the treatment of a chronic infection. Its presence suggests a low viral titer and a low degree of infectivity in persons with a chronic infection.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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