Hepatitis B

Hepatitis B (HBV) is virus that infects the liver and most adults (95%) who are infected are able to quickly recover however some have long-lasting illness that can lead to liver disease, liver cancer and death. In babies and young children, HBV can also develop into a chronic infection leading to liver cirrhosis or liver cancer later in life. 350 million people worldwide are infected with HBV and it is the cause of 620,000 deaths each year.

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Hepatitis B Products (84)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
MAb to HBcAg (ayw) Monoclonal Dil.Ascites Mouse IgG2b EIA,IHC,IP,WB,IB MG C8A035M View SDS View COA Order A Sample
HBsAg (adr), Rec Antigen Purified S. cerevisiae N/A EIA,LF MG BN1215 View SDS View COA Order A Sample
mAb to HBsAg Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1100 View SDS View COA Order A Sample
mAb to HBsAg Monoclonal Purified Mouse IgG2a,k EIA,LF,Pr MG BN1099 View SDS View COA Order A Sample
mAb to HBsAg Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1098 View SDS View COA Order A Sample
mAb to HBsAg Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1097 View SDS View COA Order A Sample
Hepatitis B Core Virus, Recomb Antigen Purified Pichia pastoris N/A WB,EIA MG VTI610 View SDS View COA Order A Sample
HBsAg (adw) Recombinant Antigen Purified S. cerevisiae N/A EIA MG R86872 View SDS View COA Order A Sample
HBsAg (ayw) Recomb. Antigen Purified S. cerevisiae N/A EIA MG R86870 View SDS View COA Order A Sample
HBsAg (adr) Recomb. Antigen Purified S. cerevisiae N/A EIA MG R86783 View SDS View COA Order A Sample
Hepatitis B Core Ag Recomb Antigen Purified E. coli N/A WB,EIA,LF MG R8A120 View SDS View COA Order A Sample
Hep B Core antigen Recomb Antigen Purified E. coli N/A EIA,WB MG R8A100 View SDS View COA Order A Sample
Hep. B Ag "e" Epitope Recomb Antigen Purified E. coli N/A EIA,WB MG R65915 View SDS View COA Order A Sample
Hb Core Ag, 19 kDa Recomb. Antigen Purified E. coli N/A EIA,WB MG R65914 View SDS View COA Order A Sample
HB pre-S1 Ag 13.5 kDa Recomb. Antigen Purified E. coli N/A EIA,WB MG R65913 View SDS View COA Order A Sample
Hepatitis B Ag 'e' Recomb Antigen Purified E. coli N/A EIA,WB MG R18915 View SDS View COA Order A Sample
HBsAg (adw) Recombinant Antigen Purified Pichia pastoris N/A EIA,WB MG R18560 View SDS View COA Order A Sample
HBsAg (adr) Recombinant Antigen Purified CHO Cells N/A EIA,LF,WB,CLI MG R01652 View SDS View COA Order A Sample
HB Pre-S2 Antigen Purified E. coli N/A EIA MG R01580 View SDS View COA Order A Sample
HB Pre-S1+S2 Antigen Purified E. coli N/A EIA MG R01579 View SDS View COA Order A Sample
HBsAg (adw) Recombinant Antigen Purified Pichia pastoris N/A EIA MG R01403 View SDS View COA Order A Sample
Hepatitis B 'e' Ag, Recomb. Antigen Purified E. coli N/A EIA MG R01401 View SDS View COA Order A Sample
HBsAg (ayw) Recombinant Antigen Purified S. cerevisiae N/A EIA,WB MG R01290 View SDS View COA Order A Sample
HBsAg (adw) Recombinant Antigen Purified S. cerevisiae N/A EIA,WB MG R01289 View SDS View COA Order A Sample
MAb to HBsAg Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAV18-511 View SDS View COA Order A Sample
MAb to HBsAg (ay) Monoclonal Purified Mouse IgG2a,k EIA,Pr MG MAV18-004 View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG2b EIA,RIA MG C92100M View SDS View COA Order A Sample
MAb to Hepatitis B 'e' antigen Monoclonal Purified Mouse IgG2b EIA,Pr MG C86843M View SDS View COA Order A Sample
MAb to Hepatitis B 'e' antigen Monoclonal Purified Mouse IgG1 EIA,Pr MG C86743M View SDS View COA Order A Sample
MAb to HBsAg (ayw) Monoclonal HRP Mouse IgG1 EIA MG C86600P View SDS View COA Order A Sample
MAb to Hepatitis B 'e' antigen Monoclonal Purified Mouse IgG2b EIA,Pr MG C86534M View SDS View COA Order A Sample
MAb to HBsAg Monoclonal HRP Mouse IgG1 EIA MG C86401P View SDS View COA Order A Sample
MAb to HBsAg Monoclonal Purified Mouse IgG1 EIA,Pr MG C86401M View SDS View COA Order A Sample
MAb to HBcAg Monoclonal Purified Mouse IgG2a EIA,Pr,WB MG C86340M View SDS View COA Order A Sample
MAb to Hepatitis B 'e' antigen Monoclonal Purified Mouse IgG2b EIA,Pr MG C86334M View SDS View COA Order A Sample
MAb to HBsAg (ayw) Monoclonal Purified Mouse IgG1 EIA,Pr MG C86322M View SDS View COA Order A Sample
MAb to HBcAg Monoclonal Purified Mouse IgG2a EIA,Pr,WB MG C86317M View SDS View COA Order A Sample
MAb to HBsAg (ayw) Monoclonal Purified Mouse IgG1 EIA,Pr MG C86312M View SDS View COA Order A Sample
MAb to HBsAg Monoclonal Purified Mouse IgG2a EIA,Pr MG C86303M View SDS View COA Order A Sample
MAb to HBcAg (ayw) Monoclonal Dil.Ascites Mouse IgG2a EIA,IHC,IP,WB,IB MG C8A038M View SDS View COA Order A Sample
MAb to HBcAg (ayw) Monoclonal Dil.Ascites Mouse IgG2b EIA,IHC,IP,WB,IB MG C8A037M View SDS View COA Order A Sample
MAb to HBcAg (ayw) (a.a.1-10) Monoclonal Dil.Ascites Mouse IgG2a EIA,IHC,IP,WB,IB MG C8A036M View SDS View COA Order A Sample
MAb to Hepatitis B Core (ayw) Monoclonal Purified Mouse IgG2b EIA,IP,WB,IB MG C8A034M View SDS View COA Order A Sample
MAb to Hepatitis B Core (ayw) Monoclonal Biotin Mouse IgG2b EIA,IP,WB,IB MG C8A034B View SDS View COA Order A Sample
MAb to HBcAg (ayw) Monoclonal Purified Mouse IgG2a EIA,IFA,WB MG C8A033M View SDS View COA Order A Sample
MAb to HBsAg (adw/ayw) Monoclonal Purified Mouse IgG1 EIA,IFA MG C8A032M View SDS View COA Order A Sample
MAb to Hepatitis B Presurface Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C8A031M View SDS View COA Order A Sample
MAb to Hepatitis B 'e' antigen Monoclonal Purified Mouse IgG2a EIA,Pr MG C65814M View SDS View COA Order A Sample
MAb to Hepatitis B 'e' antigen Monoclonal Purified Mouse IgG2a EIA,Pr MG C65318M View SDS View COA Order A Sample
MAb to Hepatitis B 'e' antigen Monoclonal Purified Mouse IgG1 EIA,Pr MG C65218M View SDS View COA Order A Sample
MAb to HBsAg (ay) Monoclonal Purified Mouse IgG1 EIA,IP,RIA MG C45704M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG1 EIA,IP,RIA MG C45100M View SDS View COA Order A Sample
MAb to HBsAg (ad) Monoclonal Purified Mouse IgG1 EIA,IP,RIA MG C45098M View SDS View COA Order A Sample
MAb to Hepatitis B 'e' Ag Monoclonal Purified Mouse IgG2a EIA,Pr MG C31170M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG1 EIA,LF,Pr MG C18286M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG1 EIA,LF,Pr MG C18212M View SDS View COA Order A Sample
MAb to HBx Monoclonal Purified Mouse IgG1 EIA,WB MG C01768M View SDS View COA Order A Sample
MAb to HBx Monoclonal Purified Mouse IgG2a EIA,WB MG C01767M View SDS View COA Order A Sample
MAb to HBx Monoclonal Purified Mouse IgG1 EIA,WB MG C01766M View SDS View COA Order A Sample
MAb to HBeAg Monoclonal Purified Mouse IgG2a EIA,Pr,LF MG C01693M View SDS View COA Order A Sample
MAb to HBeAg Monoclonal Purified Mouse IgG2b EIA,Pr,LF MG C01692M View SDS View COA Order A Sample
MAb to Hepatitis B Virus Core Monoclonal Purified Mouse IgG2a EIA,Pr MG C01558M View SDS View COA Order A Sample
MAb to Hepatitis B Virus Core Monoclonal Purified Mouse IgG2a EIA,Pr MG C01557M View SDS View COA Order A Sample
MAb to Hepatitis B Virus Core Monoclonal Purified Mouse IgG2b EIA,Pr MG C01556M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG2b,l EIA,LF,Pr MG C01465M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG1 EIA,LF,Pr MG C01458M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG1,k EIA,Pr,LF MG C01457M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG1,k EIA,LF MG C01456M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG2a,k EIA,LF,LAT MG C01455M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG1 EIA,Pr MG C01250M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG2a EIA,Pr MG C01249M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG2a EIA,Pr MG C01248M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG2a EIA,Pr MG C01247M View SDS View COA Order A Sample
MAb to HBsAg (ad/ay) Monoclonal Purified Mouse IgG2a EIA,Pr MG C01246M View COA Order A Sample
Rabbit anti HBsAg (ad/ay) Polyclonal Purified Rabbit N/A EIA ML B65811R View SDS View COA Order A Sample
Rabbit anti HBsAg (ad/ay) Polyclonal HRP Rabbit N/A EIA,Pr ML B65811P View SDS View COA Order A Sample
Rabbit anti HBsAg (ad/ay) Polyclonal FITC Rabbit N/A IFA ML B65811F View SDS View COA Order A Sample
Rabbit anti HBsAg (ad/ay) Polyclonal Biotin Rabbit N/A EIA ML B65811B View SDS View COA Order A Sample
Goat A' HBsAg (ad/ay) Polyclonal Biotin Goat N/A EIA,IEP ML B65807B View SDS View COA Order A Sample
Goat A' HBsAg (ad/ay) Polyclonal HRP Goat N/A EIA ML B65804P View SDS View COA Order A Sample
Goat A' HBsAg (ad/ay) Polyclonal FITC Goat N/A EIA,IEP ML B65803F View SDS View COA Order A Sample
Goat A'HBsAg (ad/ay) Polyclonal Purified Goat N/A EIA ML B65180G View SDS View COA Order A Sample
mAb to HBsAg Monoclonal Purified, Liquid Rabbit IgG EIA,LF MG BN1231 View COA Order A Sample
mAb to HbsAg Monoclonal Purified, Liquid CHO Cells IgG1,k EIA,LF MG BN1219 View SDS View COA Order A Sample

Hepatitis B (HBV)

Hepatitis is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes presented on its envelope proteins, and into eight genotypes (A-H) according to overall nucleotide sequence variation of the genome. The subtypes are associated geographic distribution, ethnicity, and clinical outcomes such as response to treatment. East Asia and Sub-Saharan Africa have the highest rates of BV infection (up to 15% of the adult population) and infection around the time of birth is the most frequent way HBV is acquired in areas of the world where the disease is common, as mothers pass the infection to their babies during childbirth. Overall, HBV is spread when blood, semen, or other body fluid infected with the hepatitis B virus enters the body of someone who is not infected which can happen through sexual contact, sharing needles, and blood transfusion. The likelihood of an infected individual resolving an acute HBV infection depends on their age and the strength of their initial immune response.

Diagnosis

Serologic testing of HBV involves a panel of several HBV-specific markers: HBV surface antigen (HBsAg), HBV core antigen (HBcAg) and HBV “e” antigen (HBeAg). These markers help distinguish whether a patient is susceptible to primary infection, immune as a result of a resolved infection, immune as a result of vaccination, acutely infected, or chronically infected. During acute infection, the appearance of virologic markers develop in a typical pattern. The first serologic marker to appear within 1-12 weeks of an acute infection is HBsAg, along with pre-S1 and pre-S2 antigens. Then, HBeAg becomes detectable which indicates that a person is highly infectious and clinical symptoms begin to develop. IgM antibody to HBcAg (anti-HBc) appears next and remains present for up to 4 months, after which only IgG antibody to HBcAg remains and persists indefinitely. Anti-HBe appears after anti-HBc and its presence correlates to a decreased infectivity. Acute hepatitis patients who maintain a constant serum HBsAg concentration or whose serum HBeAg persists for 8-10 weeks after symptoms have resolved, are at risk of developing chronic liver disease.

Type of HBV assays include:

Anti-HBc, IgM or Total

A positive anti-HBc IgM indicates a recent, acute infection (within the past 6 months). A positive anti-HBc Total is a non-specific assay used to detect acute, chronic, or resolved HBV infection. It may be used in pre-vaccination testing to determine previous exposure to an HBV infection, but it is not a marker of immunity.

HBsAg

Used to screen for and detect HBV infections, either recent or chronic. HBsAg is the earliest indicator of acute Hepatitis B and frequently identifies infected people before symptoms appear. HBsAg is the most widely used diagnostic and blood screening Hepatitis B test worldwide.

Anti-HBs

Used to determine immunity status. Used to detect previous exposure to HBV or to establish vaccination status. Subtypes adw, ady, and adr are each found in different geographic regions of the world. In Japan, China, and Southeast Asia, the r determinant predominates and in Europe, the US, Africa, India, Australia, and Oceania, the w determinant predominates. The y determinant is found in Africa and in Australia aborigines. (WHO, 2014)

HBeAg

A marker of a high degree of infectivity as it correlates with a high level of viral replication. Primarily used to monitor the effectiveness of treatment for chronic sufferers. However, some strains of HBV do not make “e” antigen, especially those found in the Middle East and Asia.

Anti-HBe

Used to diagnose and monitor the treatment of a chronic infection. Its presence suggests a low viral titer and a low degree of infectivity in persons with a chronic infection.

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