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SARS

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a respiratory zoonotic virus first identified in February 2003 during an outbreak that emerged in China and spread to 4 other countries.
The novel SARS-CoV-2 is a genetically closely related coronavirus responsible for the 2020 COVID-19 pandemic. The virus was first identified in the respiratory tract of patients with pneumonia in Wuhan, Hubei China, in December 2019 and declared a pandemic by the World Health Organization (WHO) on March 11, 2020.

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SARS Products (56)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog Buffer Immunogen Recombinant Description Notes SDS COA New Product Recommended Product Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1068 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1067 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF MG BN1066 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1065 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2a,k EIA,LF,Pr MG BN1064 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1063 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1062 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1061 No View SDS View COA 0 Order a Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,l EIA,LF,Pr MG BN1060 No View SDS View COA 0 Order a Sample
rec-SARS-CoV-2 NP (Wuhan) Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1017 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD (Omicron) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1016 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD (Delta) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1015 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD (Beta) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1014 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD Ag(Wuhan)hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1013 No View SDS View COA 0 Order a Sample
rec-SARS-CoV-2 RBD Ag, (XE) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1011 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD Ag, (Omicron) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1010 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD Ag, (Mu) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1009 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD Ag, (Lambda) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1008 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD Ag, (Delta) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1007 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD Ag, (Beta) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1006 No View SDS View COA 0 Order a Sample
r-SARS-CoV-2 RBD Ag, (Alpha) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1005 No View SDS View COA 0 Order a Sample
rec-SARS-CoV-2 RBD Ag (Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1004 No View SDS View COA 0 Order a Sample
rec-SARS-CoV-2 S1,P1(Gamma) Ag Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1003 No View SDS View COA 0 Order a Sample
rec-SARS-CoV-2 S1, B.1.351 Ag Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1002 No View SDS View COA 0 Order a Sample
rec-SARS-CoV-2 S1,S2 Ag(Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1001 No View SDS View COA 0 Order a Sample
rec-SARS-CoV-2 S1 Ag (Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1000 No View SDS View COA 0 Order a Sample
SARS-CoV-2 RBD,B.1.617.2delta Antigen Purified, Liquid Insect Cells N/A EIA,WB MG 9606 No View SDS View COA 0 Order a Sample
SARS-CoV-2 S1 RBD B.1.617 Antigen Liquid Human N/A EIA,LF,WB,CLI MG 9599 No View SDS View COA 0 Order a Sample
SARS-CoV-2 S1 RBD, L452rMutant Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9598 No View SDS View COA 0 Order a Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified, Liquid Human Plasma IgG1 EIA,LF,Pr MG 9572 No View SDS View COA 0 Order a Sample
SARS-CoV-2 S1 RBD, P.1 Mutant Antigen Purified Insect Cells N/A EIA,WB MG 9569 No View SDS View COA 0 Order a Sample
SARS-CoV-2 S1 RBD,B.1.351 Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9568 No View SDS View COA 0 Order a Sample
SARS-CoV-2 S1 RBD, Uk B.1.1.7 Antigen Purified Insect Cells N/A EIA,WB MG 9567 No View SDS View COA 0 Order a Sample
SARS-CoV-2, S1 Trimer Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9566 No View SDS View COA 0 Order a Sample
MAb to SARS-CoV-2, Trimeric S1 Monoclonal Purified Cell Culture IgG1 EIA,WB,LF,Pr MG 9565 No View SDS View COA 0 Order a Sample
SARS-CoV-2 NP (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9560 No View SDS View COA 0 Order a Sample
SARS-CoV-2 Spike S2 (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9559 No View SDS View COA 0 Order a Sample
SARS-CoV-2 Spike S1 (RBD) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9558 No View SDS View COA 0 Order a Sample
SARS-CoV-2 Spike S1 (NTD) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9557 No View SDS View COA 0 Order a Sample
SARS-CoV-2 Spike S1 (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9556 No View SDS View COA 0 Order a Sample
SARS-CoV-2 NP (dykddddk-tag) Antigen Aff.Pur. HEK Cells N/A EIA,LF,WB MG 9554 No View SDS View COA 0 Order a Sample
SARS-CoV-2 Spike S1 (RBD) Antigen Aff.Pur. HEK Cells N/A EIA,WB,LF MG 9552 No View SDS View COA 0 Order a Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG2b EIA,WB,LF,Pr MG 9551 No View SDS View COA 0 Order a Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG1 EIA,WB,LF,Pr MG 9550 No View SDS View COA 0 Order a Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified Cell Culture IgG1 EIA,LF,WB MG 9549 No View SDS View COA 0 Order a Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9548 No View SDS View COA 0 Order a Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9547 No View SDS View COA 0 Order a Sample
SARS-CoV-2-Omicron Spike-RBD Antigen Aff.Pur. HEK Cells N/A EIA,WB MG 9544 No View SDS View COA 0 Order a Sample
SARS-CoV, Spike (n-term) Recom Antigen Purified E. coli N/A EIA,WB MG R18850 No View SDS View COA 0 Order a Sample
SARS-CoV, Spike (c-term) Recom Antigen Purified E. coli N/A EIA,WB MG R18572 No View SDS View COA 0 Order a Sample
SARS-CoV, Spike (middle) Recom Antigen Purified E. coli N/A EIA,WB MG R18526 No View SDS View COA 0 Order a Sample
SARS-CoV, E Protein, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18520 No View SDS View COA 0 Order a Sample
SARS-CoV, Nucl.(340-390) Recom Antigen Purified E. coli N/A EIA,WB MG R18402 No View SDS View COA 0 Order a Sample
SARS-CoV, Nucl. (1-49) Recomb. Antigen Purified E. coli N/A EIA,WB MG R18325 No View SDS View COA 0 Order a Sample
Rabbit A' SARS-CoV, Spike (ct) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88502R No View SDS View COA 0 Order a Sample
Rabbit A' SARS-CoV, Spike (nt) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88139R No View SDS View COA 0 Order a Sample

SARS-CoV-2

SARS-CoV-2 is an enveloped RNA virus that has four main structural proteins including spike (S) glycoprotein, small envelope (E) glycoprotein, membrane (M) glycoprotein, and the nucleocapsid (N) protein. The spike or S glycoprotein is a transmembrane protein that forms homotrimers which protrude from the viral surface and facilitate the binding of envelope viruses to host cells via ACE2-receptors. The nucleocapsid (N protein) is the structural component of the virus necessary for viral RNA transcription and replication. The membrane or M protein plays a role in determining the shape of the virus envelope, helps to stabilize nucleocapsids and promotes the completion of viral assembly. The envelope or E protein is the smallest protein in the SARS-CoV-2 structure, and it plays a role in the production and maturation of this virus.

The pathogenesis of SARS-CoV-2 infection in humans manifests itself as mild symptoms to severe respiratory failure. Elderly patients and those with serious pre-existing diseases (e.g. hypertension, diabetes, obesity, and cardiovascular disease) tend to have more severe outcomes and the highest death rate. The main cause of death is from respiratory failure due to acute respiratory distress syndrome (ARDS) brought on by a rapid and uncontrolled inflammatory signaling cascade called a “cytokine storm”. The initial trigger for the cytokine storm is not yet known but it likely involves the immune system’s detection of a large quantity of viral antigens released by dying cells.

Diagnosis

Viral tests for COVID-19 that diagnose an acute infection rely on the detection SARS-CoV-2 nucleic acid or antigen using nasopharyngeal swabs. Most antigen detection assays use antibodies that recognize SARS-CoV-2 nucleocapsid protein as it is the most abundant viral protein. Spike protein has also been targeted, especially in assays that use alternative sample types such as saliva or nasal swabs that can be collected by an individual.

Serology tests to determine an individual’s immune status to SARS-CoV-2 use recombinant antigens to detect IgA, IgG or IgM specific antibodies. Tests that detect IgG/IgM to the nucleoprotein are relatively the most sensitive due to the high concentration of nucleoprotein and consequently, antibodies generated against the nucleoprotein. However, the RBD domain of the S-protein is the host attachment protein, and antibodies to RBD are more specific and can be neutralizing. (Sethuraman, N. et al (2020). Interpreting Diagnostic Tests for SARS-CoV-2.AMA. 323(22):2249-2251). To broaden an assay’s coverage and increase its sensitivity and specificity, several diagnostics manufactures use several antigens (e.g. N, S1, RBD) within a single assay.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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