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Severe acute respiratory syndrome coronavirus (SARS-CoV) is a respiratory zoonotic virus first identified in February 2003 during an outbreak that emerged in China and spread to 4 other countries.
The novel SARS-CoV-2 is a genetically closely related coronavirus responsible for the 2020 COVID-19 pandemic. The virus was first identified in the respiratory tract of patients with pneumonia in Wuhan, Hubei China, in December 2019 and declared a pandemic by the World Health Organization (WHO) on March 11, 2020.

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
SARS-CoV-2 RBD,B.1.617.2delta Antigen Purified, Liquid Insect Cells N/A EIA,WB MG 9606 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 S1 RBD B.1.617 Antigen Liquid Human N/A EIA,LF,WB,CLI MG 9599 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 S1 RBD, L452rMutant Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9598 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified, Liquid Human Plasma IgG1 EIA,LF,Pr MG 9572 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 S1 RBD, P.1 Mutant Antigen Purified Insect Cells N/A EIA,WB MG 9569 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 S1 RBD,B.1.351 Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9568 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 S1 RBD, Uk B.1.1.7 Antigen Purified Insect Cells N/A EIA,WB MG 9567 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2, S1 Trimer Antigen Purified Insect Cells N/A EIA,LF,WB,CLI MG 9566 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
MAb to SARS-CoV-2, Trimeric S1 Monoclonal Purified Cell Culture IgG1 EIA,WB,LF,Pr MG 9565 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 NP (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9560 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 Spike S2 (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9559 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 Spike S1 (RBD) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9558 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 Spike S1 (NTD) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9557 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 Spike S1 (His-tag) Antigen Aff.Pur. Insect Cells N/A EIA,WB MG 9556 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 NP (dykddddk-tag) Antigen Aff.Pur. HEK Cells N/A EIA,LF,WB MG 9554 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2 Spike S1 (RBD) Antigen Aff.Pur. HEK Cells N/A EIA,WB,LF MG 9552 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG2b EIA,WB,LF,Pr MG 9551 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
MAb to SARS-CoV-2 S1, Trimeric Monoclonal Purified Mouse IgG1 EIA,WB,LF,Pr MG 9550 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Purified Cell Culture IgG1 EIA,LF,WB MG 9549 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9548 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
MAb to SARS-CoV-2 Nucleocapsid Monoclonal Aff.Pur. Mouse IgG1 EIA,LF,WB MG 9547 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV-2-Omicron Spike-RBD Antigen Aff.Pur. HEK Cells N/A EIA,WB MG 9544 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV, Spike (n-term) Recom Antigen Purified E. coli N/A EIA,WB MG R18850 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV, Spike (c-term) Recom Antigen Purified E. coli N/A EIA,WB MG R18572 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV, Spike (middle) Recom Antigen Purified E. coli N/A EIA,WB MG R18526 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV, E Protein, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18520 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV, Nucl.(340-390) Recom Antigen Purified E. coli N/A EIA,WB MG R18402 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
SARS-CoV, Nucl. (1-49) Recomb. Antigen Purified E. coli N/A EIA,WB MG R18325 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Rabbit A' SARS-CoV, Spike (ct) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88502R SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Rabbit A' SARS-CoV, Spike (nt) Polyclonal Aff.Pur. Rabbit N/A EIA MG B88139R SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1068 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1067 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF MG BN1066 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1065 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2a,k EIA,LF,Pr MG BN1064 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG2b,k EIA,LF,Pr MG BN1063 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1062 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,k EIA,LF,Pr MG BN1061 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
Mab to SARS-CoV-2 NP Monoclonal Purified, Liquid Mouse IgG1,l EIA,LF,Pr MG BN1060 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
rec-SARS-CoV-2 NP (Wuhan) Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1017 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD (Omicron) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1016 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD (Delta) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1015 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD (Beta) hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1014 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD Ag(Wuhan)hFc Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1013 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
rec-SARS-CoV-2 RBD Ag, (XE) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1011 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD Ag, (Omicron) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1010 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD Ag, (Mu) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1009 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD Ag, (Lambda) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1008 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD Ag, (Delta) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1007 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD Ag, (Beta) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1006 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
r-SARS-CoV-2 RBD Ag, (Alpha) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1005 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
rec-SARS-CoV-2 RBD Ag (Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1004 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
rec-SARS-CoV-2 S1,P1(Gamma) Ag Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1003 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
rec-SARS-CoV-2 S1, B.1.351 Ag Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1002 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
rec-SARS-CoV-2 S1,S2 Ag(Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1001 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample
rec-SARS-CoV-2 S1 Ag (Wuhan) Antigen Purified, Liquid HEK Cells N/A EIA,LF MG BN1000 SDSSafety Data Sheet COACERTIFICATE OF ANALYSIS Request Sample

SARS-CoV-2

SARS-CoV-2 is an enveloped RNA virus that has four main structural proteins including spike (S) glycoprotein, small envelope (E) glycoprotein, membrane (M) glycoprotein, and the nucleocapsid (N) protein. The spike or S glycoprotein is a transmembrane protein that forms homotrimers which protrude from the viral surface and facilitate the binding of envelope viruses to host cells via ACE2-receptors. The nucleocapsid (N protein) is the structural component of the virus necessary for viral RNA transcription and replication. The membrane or M protein plays a role in determining the shape of the virus envelope, helps to stabilize nucleocapsids and promotes the completion of viral assembly. The envelope or E protein is the smallest protein in the SARS-CoV-2 structure, and it plays a role in the production and maturation of this virus.

The pathogenesis of SARS-CoV-2 infection in humans manifests itself as mild symptoms to severe respiratory failure. Elderly patients and those with serious pre-existing diseases (e.g. hypertension, diabetes, obesity, and cardiovascular disease) tend to have more severe outcomes and the highest death rate. The main cause of death is from respiratory failure due to acute respiratory distress syndrome (ARDS) brought on by a rapid and uncontrolled inflammatory signaling cascade called a “cytokine storm”. The initial trigger for the cytokine storm is not yet known but it likely involves the immune system’s detection of a large quantity of viral antigens released by dying cells.

Diagnosis

Viral tests for COVID-19 that diagnose an acute infection rely on the detection SARS-CoV-2 nucleic acid or antigen using nasopharyngeal swabs. Most antigen detection assays use antibodies that recognize SARS-CoV-2 nucleocapsid protein as it is the most abundant viral protein. Spike protein has also been targeted, especially in assays that use alternative sample types such as saliva or nasal swabs that can be collected by an individual.

Serology tests to determine an individual’s immune status to SARS-CoV-2 use recombinant antigens to detect IgA, IgG or IgM specific antibodies. Tests that detect IgG/IgM to the nucleoprotein are relatively the most sensitive due to the high concentration of nucleoprotein and consequently, antibodies generated against the nucleoprotein. However, the RBD domain of the S-protein is the host attachment protein, and antibodies to RBD are more specific and can be neutralizing. (Sethuraman, N. et al (2020). Interpreting Diagnostic Tests for SARS-CoV-2.AMA. 323(22):2249-2251). To broaden an assay’s coverage and increase its sensitivity and specificity, several diagnostics manufactures use several antigens (e.g. N, S1, RBD) within a single assay.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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