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Rubella

Rubella, also known as German Measles, is a viral illness caused by a togavirus of the genus Rubivirus and is an infection that primarily affects the skin and lymph nodes. It is generally a mild disease in adults and children, but it can have devastating effects on infants.

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
Rubella IgM Max antigen Antigen Purified Vero Cells N/A EIA,WB MG 6300 SDS COA Request Sample
Rubella RSVP antigen Antigen Purified Vero Cells N/A EIA,WB MG 6200 SDS COA Request Sample
Rubella Virus Grade IV PBS Ag Antigen Purified Vero Cells N/A EIA,WB,CLI MG 6123 SDS COA Request Sample
Rubella Virus Grade IV Ag Antigen Partially Purified Vero Cells N/A EIA,WB,CLI,Pr MG 6076 SDS COA Request Sample
Rubella Virus Grade III Ag Antigen Purified Vero Cells N/A EIA,WB ML 6075 SDS COA Request Sample
Rubella Virus E2, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18292 SDS COA Request Sample
Rubella Virus Capsid, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18092 SDS COA Request Sample
MAb to Rubella (clone #2-42) Monoclonal Purified Mouse N/A Pr MG EV9526 SDS COA Request Sample
MAb to Rubella (clone #2-6) Monoclonal Purified Mouse N/A Pr MG EV9525 SDS COA Request Sample
MAb to Rubella (E1) Monoclonal Purified Mouse IgG2a EIA,WB MG C86323M SDS COA Request Sample
MAb to Rubella (E1) Monoclonal Purified Mouse IgG2a EIA,WB MG C66503M SDS COA Request Sample
MAb to Rubella C Protein Monoclonal Purified Mouse IgG1,k EIA,IFA,WB MG C66496M SDS COA Request Sample
Goat anti-Rubella Virions Polyclonal HRP Goat N/A ICC ML B65704P SDS COA Request Sample
Goat anti-Rubella Virus Virion Polyclonal FITC Goat N/A IFA ML B65703F SDS COA Request Sample
Goat A' Rubella Virus Virions Polyclonal Purified Goat N/A IFA,HI ML B65105G SDS COA Request Sample
mAb to Rubella Monoclonal Purified, Liquid Mouse IgG2a,k EIA,LF MG BN1190 SDS COA Request Sample
mAb to Rubella Monoclonal Purified, Liquid Mouse IgG2a,k EIA,LF MG BN1189 SDS COA Request Sample

Rubella Virus

The primary medical danger of rubella is the infection of pregnant women because it can cause congenital rubella syndrome (CRS) in a developing fetus. Since the introduction of the measles-mumps-rubella (MMR) vaccine, rubella is much less common, however, several countries still do not include this vaccine in their immunization schedule. In the absence of vaccination, rubella is an endemic disease with epidemics every 6 to 9 years. Rubella is spread by coughing and sneezing and the virus resides in the nose and throat of an infected person with an average incubation period of 14-21 days. A person infected with rubella may spread the disease to others beginning one week before the rash occurs. Symptoms generally occur 2-3 weeks after exposure to the virus and includes a mild fever, headache and runny nose.

CONGENITAL INFECTION

A rubella infection just before conception (0-28 days) or during the first trimester in pregnancy has the highest rate of transmission to the fetus (90%) resulting in congenital rubella syndrome (CRS). At 14 weeks, this incidence is reduced to 52%, and by the end of the second trimester, the incidence drops to 25%. Fetal rubella infection often results in spontaneous abortion or severe fetal defects, including heart, brain, ear or eye malformations, deafness, microcephaly and mental retardation. Before the introduction of the vaccine, up to 4 babies in every 1000 live births were born with CRS.

Diagnosis

Rubella virus can be detected from nasal, throat, urine and blood specimens from infected individuals. Diagnosis is usually made by the detection of rubella-specific IgM antibodies which are usually present 4–30 days after the onset of illness. However, reliable serodiagnosis requires the discrimination of specific IgM primary rubella from persistent, reactivated or non-specific IgM reactivity. Recent infection can be confirmed or excluded by additional assays such as rubella IgG avidity and immunoblot analysis.

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