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Hepatitis C

丙型肝炎病毒(HCV)是一种主要影响肝脏的传染病。它是最严重的肝炎病毒, 可导致肝硬化、肝功能衰竭或癌症。据估计,有1.5亿至2亿人(约占世界人口的 3%)患有慢性丙型肝炎。

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姓名 种类 形式 宿主/来源 亚型 主要应用 单位   安全信息表 COA 点击此处订购样品
HCV NS3 Helicase, Rec. Ag   Purified Baculovirus N/A EIA,LF MG BN1218 View SDS View COA Order A Sample
Mab to Hepatitis C Capsid Monoclonal Purified Mouse IgG2a,k EIA,LF,Pr MG BN1102 View SDS View COA Order A Sample
Mab to Hepatitis C Capsid Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1101 View SDS View COA Order A Sample
HCV Capsid, Rec. Ag   Purified, Liquid E. coli N/A EIA,LF MG BN1037 View SDS View COA Order A Sample
HCV Capsid, Rec. Ag   Purified, Liquid E. coli N/A EIA,LF MG BN1036 View SDS View COA Order A Sample
HCV Capsid, Rec. Ag   Purified, Liquid E. coli N/A EIA,LF MG BN1035 View SDS View COA Order A Sample
HCV Capsid, Rec. Ag   Purified, Liquid E. coli N/A EIA,LF MG BN1034 View SDS View COA Order A Sample
HCV Capsid, Rec. Ag   Purified, Liquid E. coli N/A EIA,LF MG BN1033 View SDS View COA Order A Sample
HCV Chimeric, Rec. Ag   Purified, Liquid E. coli N/A EIA,LF MG BN1032 View SDS View COA Order A Sample
HCV Capsid, Rec. Ag   Purified, Liquid E. coli N/A EIA,LF MG BN1031 View SDS View COA Order A Sample
HCV NS3/Core/NS4/NS5 Rec. Ag   Purified E. coli N/A LF,EIA MG BN1250 View COA Order A Sample
HCV Core Recombinant   Purified Pichia pastoris N/A EIA,WB MG VTI710 View SDS View COA Order A Sample
HCV NS-4a+b Ag Recomb.   FITC E. coli N/A EIA,WB MG R8A611 View SDS View COA Order A Sample
HCV NS3 Ag., Recombinant   Purified E. coli N/A EIA,WB MG R8A442 View SDS View COA Order A Sample
HCV NS-4a+b Ag Recomb.   Purified E. coli N/A EIA,WB MG R8A116 View COA Order A Sample
HCV Core Ag Recomb.   Purified E. coli N/A EIA,WB MG R8A115 View SDS View COA Order A Sample
HCV NS3,c33c,Subtype 2b,Recomb   Purified E. coli N/A EIA,WB MG R18800 View SDS View COA Order A Sample
HCV Ns4 Ag, Recombinant   Purified E. coli N/A EIA,WB MG R18541 View SDS View COA Order A Sample
HCV Nucleocapsid/NS3/NS4/NS5   Purified E. coli N/A EIA,WB MG R18523 View SDS View COA Order A Sample
HCV Ns3 C33c Subtype 1a Recomb   Purified E. coli N/A EIA,WB MG R18358 View SDS View COA Order A Sample
HCV NS5, Genotype 1a, Recomb.   Purified E. coli N/A EIA,WB MG R18206 View SDS View COA Order A Sample
HCV NS5, Genotype 1, Recomb.   Purified E. coli N/A EIA,WB MG R18190 View SDS View COA Order A Sample
HCV Core Ag, Genotype 6 Recomb   Purified E. coli N/A EIA,WB MG R18180 View SDS View COA Order A Sample
HCV Core Ag, Genotype 5,recomb   Purified E. coli N/A EIA,WB MG R18170 View SDS View COA Order A Sample
HCV Core Ag,genotype 3,recomb   Purified E. coli N/A EIA,WB MG R18150 View SDS View COA Order A Sample
HCV Core Ag,genotype 1,recomb   Purified E. coli N/A EIA,WB MG R18140 View SDS View COA Order A Sample
HCV NS3/core/NS4/NS5 Recomb.   Purified E. coli N/A EIA,Pr,LF MG R01600 View SDS View COA Order A Sample
HCV NS3/core/NS4/NS5 Recomb.   Purified E. coli N/A EIA,Pr,LF MG R01599 View SDS View COA Order A Sample
HCV Core/ns3/ns4 Recombinant   Purified E. coli N/A EIA MG R01548 View SDS View COA Order A Sample
HCV Ns3, Genotype 1a, Recomb.   Purified E. coli N/A EIA MG R01518 View SDS View COA Order A Sample
HCV Ns-3 Ag, Recombinant   Purified E. coli N/A EIA MG R01234 View SDS View COA Order A Sample
MAb to HCV Ns-5a (aa2190-2300) Monoclonal Purified Mouse IgG1 EIA,IHC,WB MG C8A256M View SDS View COA Order A Sample
MAb to HCV Ns-4b(aa 1710-1730) Monoclonal Purified Mouse IgG2b EIA,IHC,WB MG C8A246M View SDS View COA Order A Sample
MAb to HCV Ns-4a(aa 1700-1710) Monoclonal Purified Mouse IgG1 EIA,IHC,WB MG C8A236M View SDS View COA Order A Sample
MAb to HCV Ns-3 (aa 1350-1460) Monoclonal Purified Mouse IgG1 EIA,IHC MG C8A217M View SDS View COA Order A Sample
MAb to HCV Core Ag (a.a.70-90) Monoclonal Purified Mouse IgG1 EIA,IHC,WB MG C8A216M View SDS View COA Order A Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG2a EIA,WB MG C8A117M View SDS View COA Order A Sample
MAb to HCV Core antigen Monoclonal Supernatant Mouse IgG1 EIA,WB MG C8A116M View SDS View COA Order A Sample
MAb to HCV NS-4 Monoclonal Purified Mouse IgG2a EIA,WB MG C8A018M View SDS View COA Order A Sample
MAb to HCV NS-4 Monoclonal FITC Mouse IgG2a EIA,IFA,IHC,WB MG C8A018F View SDS View COA Order A Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG2a EIA MG C8A017M View SDS View COA Order A Sample
MAb to HCV Core antigen Monoclonal Biotin Mouse IgG2a EIA MG C8A017B View SDS View COA Order A Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG2a EIA MG C8A016M View SDS View COA Order A Sample
MAb to HCV Core antigen Monoclonal FITC Mouse IgG2a EIA,IFA,IHC MG C8A016F View SDS View COA Order A Sample
MAb to HCV Core antigen Monoclonal Biotin Mouse IgG2a EIA,IHC MG C8A016B View SDS View COA Order A Sample
MAb to HCV Ns-3 Monoclonal Purified Mouse IgG2 EIA,WB MG C65859M View SDS View COA Order A Sample
MAb to HCV NS-5a Monoclonal Purified Mouse IgG2a EIA,IFA,WB MG C65388M View SDS View COA Order A Sample
MAb to HCV NS-3 Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65371M View COA Order A Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG1 EIA,IFA,IHC,Pr,WB MG C65317M View SDS View COA Order A Sample
MAb to HCV E1 Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65198M View SDS View COA Order A Sample
MAb to HCV Core Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65185M View SDS View COA Order A Sample
MAb to HCV E2 Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65167M View SDS View COA Order A Sample
MAb to HCV Core Monoclonal Purified Mouse IgG1 EIA,Pr MG C11423M View SDS View COA Order A Sample
MAb Hepatitis C Virus (HCV) Monoclonal Purified Mouse IgG1 EIA,IFA,Pr,WB MG C01253M View SDS View COA Order A Sample
MAb Hepatitis C Virus (HCV) Monoclonal Purified Mouse IgG1 EIA,IFA,Pr MG C01252M View SDS View COA Order A Sample
MAb Hepatitis C Virus (HCV) Monoclonal Purified Mouse IgG2a EIA,Pr MG C01251M View SDS View COA Order A Sample
MAb to HCV NS-4b Monoclonal Purified Mouse IgG1 EIA,WB MG C01237M View SDS View COA Order A Sample
Goat anti HCV E2 Polyclonal Purified Goat N/A EIA,IFA,WB ML B65581G View SDS View COA Order A Sample
Goat anti HCV NS-4 Polyclonal Purified Goat N/A EIA,WB ML B65188G View SDS View COA Order A Sample
Goat anti HCV NS-3 Polyclonal Purified Goat N/A EIA,IFA,WB ML B65178G View SDS View COA Order A Sample
Goat anti HCV Core Polyclonal Purified Goat N/A EIA,WB ML B65168G View SDS View COA Order A Sample
Goat anti HCV E1 Polyclonal Purified Goat N/A EIA,IFA,WB ML B01437G View SDS View COA Order A Sample
HCV NS4, Rec. Ag   Purified E. coli N/A EIA,LF MG BN1216 View SDS View COA Order A Sample

丙肝 (HCV)

世界上有6种主要的丙型肝炎病毒(基因型),它们的地理 分布各不相同。基因型1是世界上最常见的菌株,被认为 是最具侵略性的,其次是基因型2和3。基因型4、5和6在 区域上更集中于非洲(4型)、南非(5型)以及东南亚和中国 (6型)。 尽管不需要对HCV基因分型分析诊断, 但它给开 具丙肝治疗处方提供了重要信心,因为每个菌株对于治疗 丙肝病毒感染的药物反应都不同。

由于受感染者通常不知道自己接触过病毒,也没有出现任 何症状,因此大多数急性肝炎感染没有得到及时治疗。大 约85%的感染会发展为慢性肝炎,在常规医学检查中发现 肝损伤之前,几十年内都无法确诊。如果不及时治疗,慢 性丙型肝炎病毒感染可导致严重的并发症,包括肝硬化、 肝癌和肝功能衰竭。

诊断

目前主要的两种丙型肝炎病毒诊断检测为:

  • 血清学检测丙型肝炎病毒抗体或抗原
  • 分子检测,检测、量化 和/或表征感染患者的丙型肝炎病毒RNA基因组。
  • 自1990年以来,基于血清学的检测方法已被用于筛选捐献血液, 并在有症状的患者中诊断丙型肝炎病毒感染。分子分析,如基于PCR的检测,通常只用于确认或确定丙型肝炎病毒 的基因型。

    多年来,已经开发了四代抗HCV检测,每一代都提高了检测HCV的灵敏度。现在新一代的检测能够测出整个核衣 壳核心抗原,其序列在所有丙型肝炎病毒基因型中高度保守,使早期检测丙型肝炎病毒感染成为可能。这些检测使 用从多个HCV基因型的核心、NS3、NS4和NS5区域提取的所有基因型重组抗原的混合物,以及对多个基因型具有 特异性的抗HCV核心抗体。

    HCV 核心抗原检测

    丙型肝炎核心抗原可在感染后不久、病毒抗体形成之前检测到,并可在整个慢性感染过程中检测到。对输血环境的评估 表明,HCV 核心抗原检测HCV感染与NAT一样有效,比目前的第三代抗HCV筛选检测早40-50天。丙肝病毒核心抗原 水平与丙肝病毒RNA含量密切相关,因此无论丙肝病毒基因型是什么均可以用来临床监测病人的治疗。

    HCV 抗体检测

    丙型肝炎病毒抗体测试通常用于筛查有危险因素的个人、有肝炎或肝病相关症状的人,或曾接触过病毒的人。通常在确诊后 进行核酸检测,以检测丙型肝炎病毒RNA,确认是否是活跃的病毒感染。确认检测是必不可少的,因为有15%至50%的丙型 肝炎抗体感染者在接触丙型肝炎病毒后的头六个月内会自行清除丙型肝炎病毒感染,而且没有慢性感染。在慢性感染的患者 中,抗丙型肝炎病毒的存在是无限期的,但在血液透析患者或严重免疫抑制的病例中,抗体可能无法检测到。

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