Hepatitis C

Hepatitis C virus (HCV) is an infectious disease that primarily affects the liver. It is the most serious type of hepatitis virus and can lead to cirrhosis and liver failure or cancer. It is estimated that 150–200 million people, or about 3% of the world’s population, are living with chronic HCV.

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Name	Type	Format	Host/Source	Isotype	Tested Apps	Unit	Catalog	SDS	COA	Request Sample
HCV Core Recombinant	Antigen	Purified	Pichia pastoris	N/A	EIA,WB	MG	VTI710	SDS	COA	Request Sample
HCV NS-4a+b Ag Recomb.	Antigen	FITC	E. coli	N/A	EIA,WB	MG	R8A611		COA	Request Sample
HCV NS3 Ag., Recombinant	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R8A442		COA	Request Sample
HCV NS-4a+b Ag Recomb.	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R8A116		COA	Request Sample
HCV Core Ag Recomb.	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R8A115	SDS	COA	Request Sample
HCV NS3,c33c,Subtype 2b,Recomb	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18800	SDS	COA	Request Sample
HCV Ns4 Ag, Recombinant	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18541		COA	Request Sample
HCV Nucleocapsid/NS3/NS4/NS5	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18523	SDS	COA	Request Sample
HCV Ns3 C33c Subtype 1a Recomb	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18358	SDS	COA	Request Sample
HCV NS5, Genotype 1a, Recomb.	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18206	SDS	COA	Request Sample
HCV NS5, Genotype 1, Recomb.	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18190		COA	Request Sample
HCV Core Ag, Genotype 6 Recomb	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18180		COA	Request Sample
HCV Core Ag, Genotype 5,recomb	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18170		COA	Request Sample
HCV Core Ag,genotype 3,recomb	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18150		COA	Request Sample
HCV Core Ag,genotype 1,recomb	Antigen	Purified	E. coli	N/A	EIA,WB	MG	R18140		COA	Request Sample
HCV NS3/core/NS4/NS5 Recomb.	Antigen	Purified	E. coli	N/A	EIA,Pr,LF	MG	R01600	SDS	COA	Request Sample
HCV NS3/core/NS4/NS5 Recomb.	Antigen	Purified	E. coli	N/A	EIA,Pr,LF	MG	R01599	SDS	COA	Request Sample
HCV Core/ns3/ns4 Recombinant	Antigen	Purified	E. coli	N/A	EIA	MG	R01548	SDS	COA	Request Sample
HCV Ns3, Genotype 1a, Recomb.	Antigen	Purified	E. coli	N/A	EIA	MG	R01518	SDS	COA	Request Sample
HCV Ns-3 Ag, Recombinant	Antigen	Purified	E. coli	N/A	EIA	MG	R01234		COA	Request Sample
MAb to HCV Ns-5a (aa2190-2300)	Monoclonal	Purified	Mouse	IgG1	EIA,IHC,WB	MG	C8A256M	SDS	COA	Request Sample
MAb to HCV Ns-4b(aa 1710-1730)	Monoclonal	Purified	Mouse	IgG2b	EIA,IHC,WB	MG	C8A246M	SDS	COA	Request Sample
MAb to HCV Ns-4a(aa 1700-1710)	Monoclonal	Purified	Mouse	IgG1	EIA,IHC,WB	MG	C8A236M	SDS	COA	Request Sample
MAb to HCV Ns-3 (aa 1350-1460)	Monoclonal	Purified	Mouse	IgG1	EIA,IHC	MG	C8A217M	SDS	COA	Request Sample
MAb to HCV Core Ag (a.a.70-90)	Monoclonal	Purified	Mouse	IgG1	EIA,IHC,WB	MG	C8A216M	SDS	COA	Request Sample
MAb to HCV Core antigen	Monoclonal	Purified	Mouse	IgG2a	EIA,WB	MG	C8A117M	SDS	COA	Request Sample
MAb to HCV Core antigen	Monoclonal	Supernatant	Mouse	IgG1	EIA,WB	MG	C8A116M	SDS	COA	Request Sample
MAb to HCV NS-4	Monoclonal	Purified	Mouse	IgG2a	EIA,WB	MG	C8A018M	SDS	COA	Request Sample
MAb to HCV NS-4	Monoclonal	FITC	Mouse	IgG2a	EIA,IFA,IHC,WB	MG	C8A018F	SDS	COA	Request Sample
MAb to HCV Core antigen	Monoclonal	Purified	Mouse	IgG2a	EIA	MG	C8A017M	SDS	COA	Request Sample
MAb to HCV Core antigen	Monoclonal	Biotin	Mouse	IgG2a	EIA	MG	C8A017B	SDS	COA	Request Sample
MAb to HCV Core antigen	Monoclonal	Purified	Mouse	IgG2a	EIA	MG	C8A016M	SDS	COA	Request Sample
MAb to HCV Core antigen	Monoclonal	FITC	Mouse	IgG2a	EIA,IFA,IHC	MG	C8A016F	SDS	COA	Request Sample
MAb to HCV Core antigen	Monoclonal	Biotin	Mouse	IgG2a	EIA,IHC	MG	C8A016B	SDS	COA	Request Sample
MAb to HCV Ns-3	Monoclonal	Purified	Mouse	IgG2	EIA,WB	MG	C65859M		COA	Request Sample
MAb to HCV NS-5a	Monoclonal	Purified	Mouse	IgG2a	EIA,IFA,WB	MG	C65388M		COA	Request Sample
MAb to HCV NS-3	Monoclonal	Purified	Mouse	IgG1	EIA,IFA,WB	MG	C65371M		COA	Request Sample
MAb to HCV Core antigen	Monoclonal	Purified	Mouse	IgG1	EIA,IFA,IHC,Pr,WB	MG	C65317M		COA	Request Sample
MAb to HCV E1	Monoclonal	Purified	Mouse	IgG1	EIA,IFA,WB	MG	C65198M		COA	Request Sample
MAb to HCV Core	Monoclonal	Purified	Mouse	IgG1	EIA,IFA,WB	MG	C65185M		COA	Request Sample
MAb to HCV E2	Monoclonal	Purified	Mouse	IgG1	EIA,IFA,WB	MG	C65167M	SDS	COA	Request Sample
MAb to HCV Core	Monoclonal	Purified	Mouse	IgG1	EIA,Pr	MG	C11423M	SDS	COA	Request Sample
MAb Hepatitis C Virus (HCV)	Monoclonal	Purified	Mouse	IgG1	EIA,IFA,Pr,WB	MG	C01253M		COA	Request Sample
MAb Hepatitis C Virus (HCV)	Monoclonal	Purified	Mouse	IgG1	EIA,IFA,Pr	MG	C01252M	SDS	COA	Request Sample
MAb Hepatitis C Virus (HCV)	Monoclonal	Purified	Mouse	IgG2a	EIA,Pr	MG	C01251M		COA	Request Sample
MAb to HCV NS-4b	Monoclonal	Purified	Mouse	IgG1	EIA,WB	MG	C01237M		COA	Request Sample
Goat anti HCV E2	Polyclonal	Purified	Goat	N/A	EIA,IFA,WB	ML	B65581G		COA	Request Sample
Goat anti HCV NS-4	Polyclonal	Purified	Goat	N/A	EIA,WB	ML	B65188G		COA	Request Sample
Goat anti HCV NS-3	Polyclonal	Purified	Goat	N/A	EIA,IFA,WB	ML	B65178G		COA	Request Sample
Goat anti HCV Core	Polyclonal	Purified	Goat	N/A	EIA,WB	ML	B65168G		COA	Request Sample
Goat anti HCV E1	Polyclonal	Purified	Goat	N/A	EIA,IFA,WB	ML	B01437G		COA	Request Sample
HCV NS4, Rec. Ag	Antigen	Purified	E. coli	N/A	EIA,LF	MG	BN1216	SDS	COA	Request Sample
Mab to Hepatitis C Capsid	Monoclonal	Purified	Mouse	IgG2a,k	EIA,LF,Pr	MG	BN1102	SDS	COA	Request Sample
Mab to Hepatitis C Capsid	Monoclonal	Purified	Mouse	IgG1,k	EIA,LF,Pr	MG	BN1101	SDS	COA	Request Sample
HCV Capsid, Rec. Ag	Antigen	Purified, Liquid	E. coli	N/A	EIA,LF	MG	BN1037	SDS	COA	Request Sample
HCV Capsid, Rec. Ag	Antigen	Purified, Liquid	E. coli	N/A	EIA,LF	MG	BN1036	SDS	COA	Request Sample
HCV Capsid, Rec. Ag	Antigen	Purified, Liquid	E. coli	N/A	EIA,LF	MG	BN1035	SDS	COA	Request Sample
HCV Capsid, Rec. Ag	Antigen	Purified, Liquid	E. coli	N/A	EIA,LF	MG	BN1034	SDS	COA	Request Sample
HCV Capsid, Rec. Ag	Antigen	Purified, Liquid	E. coli	N/A	EIA,LF	MG	BN1033	SDS	COA	Request Sample
HCV Chimeric, Rec. Ag	Antigen	Purified, Liquid	E. coli	N/A	EIA,LF	MG	BN1032	SDS	COA	Request Sample
HCV Capsid, Rec. Ag	Antigen	Purified, Liquid	E. coli	N/A	EIA,LF	MG	BN1031	SDS	COA	Request Sample

Hepatitis

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Hepatitis C (HCV)

There are 6 major strains (genotypes) of HCV worldwide, which vary in their geographic distribution. Genotype 1 is the most common strain worldwide and it is considered to be the most aggressive, followed by genotypes 2 and 3. Genotypes 4, 5 and 6 are more regionally focused to areas such as Africa (type 4), South Africa (type 5) and Southeast Asia and China (type 6). Although HCV genotyping assays are not required to diagnose an HCV infection, it is critical information for prescribing HCV treatment since each strain responds differently to the various medications. Most acute hepatitis infections do not get treated as infected individuals are usually unaware they have been exposed to the virus and they do not develop any symptoms. About 85% of infections will progress to chronic hepatitis and remain undiagnosed for several decades until liver damage is detected during routine medical exams. A chronic HCV infection that is left untreated can cause serious complications including liver cirrhosis, liver cancer and liver failure.

Diagnosis

There are two main types of diagnostic tests for HCV:

serological assays that detect antibody or antigen to HCV
molecular assays that detect, quantify, and/or characterize HCV RNA genomes within an infected patient

Since 1990, serologic-based assays have been used to screen blood donations and to diagnose an HCV infection in symptomatic patients. Molecular assays such as PCR-based tests are generally only used as confirmation or to determine the HCV genotype. Over the years, four generations of anti-HCV tests have been developed, and each generation has resulted in an improvement in the sensitivity of detecting HCV. New-generation tests are now able to detect the total nucleocapsid core antigen whose sequence is highly conserved across all HCV genotypes, allowing for the earlier detection of an HCV infection. These assays employ a cocktail of all genotype recombinant antigens derived from the core, NS3, NS4, and NS5 regions of multiple HCV genotypes and an anti-HCV core antibody with specificity for multiple genotypes.

HCV Core Antigen Test

Hepatitis C core antigen can be detected soon after infection, before the development of antibodies to the virus, and remains detectable throughout chronic infection. Evaluations in transfusion settings have shown that the HCV Core Ag assay detects HCV infection as effectively as NAT, about 40-50 days earlier than the current third generation anti-HCV screening assays. HCV core antigen levels closely follow HCV RNA dynamics, and allow clinical monitoring of a patient’s therapy, independently of HCV genotype.

HCV Antibody Test

The HCV antibody test is commonly used to screen individuals with risk factors, people who have symptoms associated with hepatitis or liver disease, or those who have been exposed to the virus. It is generally followed by a confirmatory nucleic acid test to detect HCV RNA, which indicates an active viral infection. The confirmatory test is essential because between 15 and 50% of people with HCV antibodies will have spontaneously cleared HCV infection during the first six months after exposure and do not have chronic infection. Anti-HCV persists indefinitely in patients who develop chronic infection, although antibodies may become undetectable in hemodialysis patients or in cases of profound immunosuppression.

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