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Hepatitis C

Hepatitis C virus (HCV) is an infectious disease that primarily affects the liver. It is the most serious type of hepatitis virus and can lead to cirrhosis and liver failure or cancer. It is estimated that 150–200 million people, or about 3% of the world’s population, are living with chronic HCV.

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Hepatitis C Products (63)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog Buffer Immunogen Recombinant Description Notes SDS COA New Product Recommended Product Order a Sample
HCV NS3 Helicase, Rec. Ag Antigen Purified Baculovirus N/A EIA,LF MG BN1218 No View SDS View COA 0 Order a Sample
Mab to Hepatitis C Capsid Monoclonal Purified Mouse IgG2a,k EIA,LF,Pr MG BN1102 No View SDS View COA 0 Order a Sample
Mab to Hepatitis C Capsid Monoclonal Purified Mouse IgG1,k EIA,LF,Pr MG BN1101 No View SDS View COA 0 Order a Sample
HCV Capsid, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1037 No View SDS View COA 0 Order a Sample
HCV Capsid, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1036 No View SDS View COA 0 Order a Sample
HCV Capsid, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1035 No View SDS View COA 0 Order a Sample
HCV Capsid, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1034 No View SDS View COA 0 Order a Sample
HCV Capsid, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1033 No View SDS View COA 0 Order a Sample
HCV Chimeric, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1032 No View SDS View COA 0 Order a Sample
HCV Capsid, Rec. Ag Antigen Purified, Liquid E. coli N/A EIA,LF MG BN1031 No View SDS View COA 0 Order a Sample
HCV NS3/Core/NS4/NS5 Rec. Ag Antigen Purified E. coli N/A LF,EIA MG BN1250 No View COA 0 Order a Sample
HCV Core Recombinant Antigen Purified Pichia pastoris N/A EIA,WB MG VTI710 No View SDS View COA 0 Order a Sample
HCV NS-4a+b Ag Recomb. Antigen FITC E. coli N/A EIA,WB MG R8A611 No View SDS View COA 0 Order a Sample
HCV NS3 Ag., Recombinant Antigen Purified E. coli N/A EIA,WB MG R8A442 No View SDS View COA 0 Order a Sample
HCV NS-4a+b Ag Recomb. Antigen Purified E. coli N/A EIA,WB MG R8A116 No View COA 0 Order a Sample
HCV Core Ag Recomb. Antigen Purified E. coli N/A EIA,WB MG R8A115 No View SDS View COA 0 Order a Sample
HCV NS3,c33c,Subtype 2b,Recomb Antigen Purified E. coli N/A EIA,WB MG R18800 No View SDS View COA 0 Order a Sample
HCV Ns4 Ag, Recombinant Antigen Purified E. coli N/A EIA,WB MG R18541 No View SDS View COA 0 Order a Sample
HCV Nucleocapsid/NS3/NS4/NS5 Antigen Purified E. coli N/A EIA,WB MG R18523 No View SDS View COA 0 Order a Sample
HCV Ns3 C33c Subtype 1a Recomb Antigen Purified E. coli N/A EIA,WB MG R18358 No View SDS View COA 0 Order a Sample
HCV NS5, Genotype 1a, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18206 No View SDS View COA 0 Order a Sample
HCV NS5, Genotype 1, Recomb. Antigen Purified E. coli N/A EIA,WB MG R18190 No View SDS View COA 0 Order a Sample
HCV Core Ag, Genotype 6 Recomb Antigen Purified E. coli N/A EIA,WB MG R18180 No View SDS View COA 0 Order a Sample
HCV Core Ag, Genotype 5,recomb Antigen Purified E. coli N/A EIA,WB MG R18170 No View SDS View COA 0 Order a Sample
HCV Core Ag,genotype 3,recomb Antigen Purified E. coli N/A EIA,WB MG R18150 No View SDS View COA 0 Order a Sample
HCV Core Ag,genotype 1,recomb Antigen Purified E. coli N/A EIA,WB MG R18140 No View SDS View COA 0 Order a Sample
HCV NS3/core/NS4/NS5 Recomb. Antigen Purified E. coli N/A EIA,Pr,LF MG R01600 No View SDS View COA 0 Order a Sample
HCV NS3/core/NS4/NS5 Recomb. Antigen Purified E. coli N/A EIA,Pr,LF MG R01599 No View SDS View COA 0 Order a Sample
HCV Core/ns3/ns4 Recombinant Antigen Purified E. coli N/A EIA MG R01548 No View SDS View COA 0 Order a Sample
HCV Ns3, Genotype 1a, Recomb. Antigen Purified E. coli N/A EIA MG R01518 No View SDS View COA 0 Order a Sample
HCV Ns-3 Ag, Recombinant Antigen Purified E. coli N/A EIA MG R01234 No View SDS View COA 0 Order a Sample
MAb to HCV Ns-5a (aa2190-2300) Monoclonal Purified Mouse IgG1 EIA,IHC,WB MG C8A256M No View SDS View COA 0 Order a Sample
MAb to HCV Ns-4b(aa 1710-1730) Monoclonal Purified Mouse IgG2b EIA,IHC,WB MG C8A246M No View SDS View COA 0 Order a Sample
MAb to HCV Ns-4a(aa 1700-1710) Monoclonal Purified Mouse IgG1 EIA,IHC,WB MG C8A236M No View SDS View COA 0 Order a Sample
MAb to HCV Ns-3 (aa 1350-1460) Monoclonal Purified Mouse IgG1 EIA,IHC MG C8A217M No View SDS View COA 0 Order a Sample
MAb to HCV Core Ag (a.a.70-90) Monoclonal Purified Mouse IgG1 EIA,IHC,WB MG C8A216M No View SDS View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG2a EIA,WB MG C8A117M No View SDS View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal Supernatant Mouse IgG1 EIA,WB MG C8A116M No View SDS View COA 0 Order a Sample
MAb to HCV NS-4 Monoclonal Purified Mouse IgG2a EIA,WB MG C8A018M No View SDS View COA 0 Order a Sample
MAb to HCV NS-4 Monoclonal FITC Mouse IgG2a EIA,IFA,IHC,WB MG C8A018F No View SDS View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG2a EIA MG C8A017M No View SDS View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal Biotin Mouse IgG2a EIA MG C8A017B No View SDS View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG2a EIA MG C8A016M No View SDS View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal FITC Mouse IgG2a EIA,IFA,IHC MG C8A016F No View SDS View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal Biotin Mouse IgG2a EIA,IHC MG C8A016B No View SDS View COA 0 Order a Sample
MAb to HCV Ns-3 Monoclonal Purified Mouse IgG2 EIA,WB MG C65859M No View SDS View COA 0 Order a Sample
MAb to HCV NS-5a Monoclonal Purified Mouse IgG2a EIA,IFA,WB MG C65388M No View SDS View COA 0 Order a Sample
MAb to HCV NS-3 Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65371M No View COA 0 Order a Sample
MAb to HCV Core antigen Monoclonal Purified Mouse IgG1 EIA,IFA,IHC,Pr,WB MG C65317M No View SDS View COA 0 Order a Sample
MAb to HCV E1 Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65198M No View SDS View COA 0 Order a Sample
MAb to HCV Core Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65185M No View SDS View COA 0 Order a Sample
MAb to HCV E2 Monoclonal Purified Mouse IgG1 EIA,IFA,WB MG C65167M No View SDS View COA 0 Order a Sample
MAb to HCV Core Monoclonal Purified Mouse IgG1 EIA,Pr MG C11423M No View SDS View COA 0 Order a Sample
MAb Hepatitis C Virus (HCV) Monoclonal Purified Mouse IgG1 EIA,IFA,Pr,WB MG C01253M No View SDS View COA 0 Order a Sample
MAb Hepatitis C Virus (HCV) Monoclonal Purified Mouse IgG1 EIA,IFA,Pr MG C01252M No View SDS View COA 0 Order a Sample
MAb Hepatitis C Virus (HCV) Monoclonal Purified Mouse IgG2a EIA,Pr MG C01251M No View SDS View COA 0 Order a Sample
MAb to HCV NS-4b Monoclonal Purified Mouse IgG1 EIA,WB MG C01237M No View SDS View COA 0 Order a Sample
Goat anti HCV E2 Polyclonal Purified Goat N/A EIA,IFA,WB ML B65581G No View SDS View COA 0 Order a Sample
Goat anti HCV NS-4 Polyclonal Purified Goat N/A EIA,WB ML B65188G No View SDS View COA 0 Order a Sample
Goat anti HCV NS-3 Polyclonal Purified Goat N/A EIA,IFA,WB ML B65178G No View SDS View COA 0 Order a Sample
Goat anti HCV Core Polyclonal Purified Goat N/A EIA,WB ML B65168G No View SDS View COA 0 Order a Sample
Goat anti HCV E1 Polyclonal Purified Goat N/A EIA,IFA,WB ML B01437G No View SDS View COA 0 Order a Sample
HCV NS4, Rec. Ag Antigen Purified E. coli N/A EIA,LF MG BN1216 No View SDS View COA 0 Order a Sample

Hepatitis C (HCV)

There are 6 major strains (genotypes) of HCV worldwide, which vary in their geographic distribution. Genotype 1 is the most common strain worldwide and it is considered to be the most aggressive, followed by genotypes 2 and 3. Genotypes 4, 5 and 6 are more regionally focused to areas such as Africa (type 4), South Africa (type 5) and Southeast Asia and China (type 6). Although HCV genotyping assays are not required to diagnose an HCV infection, it is critical information for prescribing HCV treatment since each strain responds differently to the various medications. Most acute hepatitis infections do not get treated as infected individuals are usually unaware they have been exposed to the virus and they do not develop any symptoms. About 85% of infections will progress to chronic hepatitis and remain undiagnosed for several decades until liver damage is detected during routine medical exams. A chronic HCV infection that is left untreated can cause serious complications including liver cirrhosis, liver cancer and liver failure.

Diagnosis

There are two main types of diagnostic tests for HCV:

  1. serological assays that detect antibody or antigen to HCV
  2. molecular assays that detect, quantify, and/or characterize HCV RNA genomes within an infected patient

Since 1990, serologic-based assays have been used to screen blood donations and to diagnose an HCV infection in symptomatic patients. Molecular assays such as PCR-based tests are generally only used as confirmation or to determine the HCV genotype. Over the years, four generations of anti-HCV tests have been developed, and each generation has resulted in an improvement in the sensitivity of detecting HCV. New-generation tests are now able to detect the total nucleocapsid core antigen whose sequence is highly conserved across all HCV genotypes, allowing for the earlier detection of an HCV infection. These assays employ a cocktail of all genotype recombinant antigens derived from the core, NS3, NS4, and NS5 regions of multiple HCV genotypes and an anti-HCV core antibody with specificity for multiple genotypes.

HCV Core Antigen Test

Hepatitis C core antigen can be detected soon after infection, before the development of antibodies to the virus, and remains detectable throughout chronic infection. Evaluations in transfusion settings have shown that the HCV Core Ag assay detects HCV infection as effectively as NAT, about 40-50 days earlier than the current third generation anti-HCV screening assays. HCV core antigen levels closely follow HCV RNA dynamics, and allow clinical monitoring of a patient’s therapy, independently of HCV genotype.

HCV Antibody Test

The HCV antibody test is commonly used to screen individuals with risk factors, people who have symptoms associated with hepatitis or liver disease, or those who have been exposed to the virus. It is generally followed by a confirmatory nucleic acid test to detect HCV RNA, which indicates an active viral infection. The confirmatory test is essential because between 15 and 50% of people with HCV antibodies will have spontaneously cleared HCV infection during the first six months after exposure and do not have chronic infection. Anti-HCV persists indefinitely in patients who develop chronic infection, although antibodies may become undetectable in hemodialysis patients or in cases of profound immunosuppression.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!


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