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| Library | Average mapped reads (%) |
|---|---|
| Lyophilized reagents | 99.79 ± 0.04 |
| Liquid reagents | 99.79 ± 0.12 |
Comparison of libraries created using lyophilized and liquid formulations. The table shows mapping efficiency, while the chart displays the GC content of the libraries generated with lyophilized and liquid reagents. In both cases, lyophilized and liquid formulations showed similar results, with good mapping efficiency and comparable GC content.
Meridian’s glycerol-free NGS Library Prep Enzymes enable high-fidelity, high-efficiency library preparation, allowing sequencing kits to be shipped and stored at ambient temperature for greater accessibility. Ambient-temperature NGS assays eliminate cold-chain logistics, expanding access to genomic testing in resource-limited settings. By driving scalable, high-performance sequencing technologies, Meridian is bridging the gap, making NGS-based diagnostics more accessible, efficient, and impactful worldwide.
Next-generation sequencing (NGS) is widely used in clinical diagnostics and precision medicine, with applications spanning oncology, infectious disease, reproductive health, and genetic disorder screening. In cancer care, NGS supports companion diagnostics (CDx) for targeted therapies, minimal residual disease (MRD) monitoring, and liquid biopsy for non-invasive tumor detection. It plays a crucial role in infectious disease diagnostics, identifying pathogens, antimicrobial resistance markers, and tracking viral outbreaks. In reproductive medicine, NGS enables non-invasive prenatal testing (NIPT), carrier screening, and preimplantation genetic testing (PGT). Additionally, it is instrumental in rare disease diagnosis, pharmacogenomics, transplant medicine, and neurological disorder screening, offering personalized insights for treatment decisions. As NGS technology advances, its role in cardiovascular risk assessment, immunogenetics, and population genomics continues to expand, further integrating precision medicine into routine clinical practice.
A customer challenge solved through collaborative R&D.
In this compilation video, 4bases and Meridian Life Science share how they collaborated to overcome the limitations of liquid reagents in an innovative NGS workflow. Together, they adapted the chemistry and optimized a scalable lyophilized solution for Oxford Nanopore applications—supporting broader global deployment.
Next-Generation Sequencing (NGS)
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The article discusses the significant rise in sexually transmitted diseases and the corresponding growth of the STD diagnostics market. It highlights how technological advancements and increased awareness are driving the development of new testing methods that are more accessible and effective, facilitating early detection and prevention strategies.
References: Zalis, M., Viana Veloso, G. G., Aguiar Jr., P. N., Gimenes, N., Reis, M. X., Matsas, S., & Ferreira, C. G. (2024). Next-generation sequencing impact on cancer care: Applications, challenges, and future directions. Frontiers in Genetics, 15, 1420190. https://doi.org/10.3389/fgene.2024.1420190
Meric-Bernstam, F., Brusco, L., Daniels, M., Wathoo, C., Bailey, A. M., Strong, L., & Shaw, K. (2019). Clinical applications of next-generation sequencing in precision oncology. NPJ Precision Oncology, 3, 4. https://doi.org/10.1038/s41698-019-0073-4
To detect more alterations, consider adding companion testing to NGS. (n.d.). Targeted Oncology. Retrieved from https://www.targetedonc.com/view/to-detect-more-alterations-consider-adding-companion-testing-to-ngs
| Specimen Type |
|---|
| Application |
| Catalog |
| Sizes |
| Wet(Liquid) |
| Air-Dryable |
| Glycerol-Free |
| Lyo-Ready |
| Concentration |
| High Concentration |
| Description |
| Request Sample |
