Featured Scientific Session

From Copy Number to Cytogenomic Complexity: Expanding the Reach of lpWGS ​​

Date/Time/Location: Wednesday 21st October @ 3:00 – 4:00 pm, Room 519B

Presented by Valentina Favalli

Technical Director, 4bases

Join Valentina Favalli to explore how low-pass whole-genome sequencing (lpWGS) and KaryoSolver could combine copy-number analysis with broader cytogenomic insights, including allelic imbalance, regions of homozygosity, uniparental disomy, mosaic events and structural rearrangements.

The session will feature selected cases from an ongoing retrospective clinical study, together with a lyophilized library-preparation chemistry developed by 4bases in collaboration with Meridian Life Science to simplify reagent handling and support workflow standardization.

Together, streamlined preparation, genome-wide sequencing and dedicated analysis could help expand lpWGS from a copy-number assay into a broader cytogenomic platform.

Watch the video with 4bases

Hear Fabio Grandi and Valentina Favalli share why 4bases went looking for a solution, what it was like working with Meridian, and what ambient stability has enabled.

Meet Us at ASHG

Stop by Booth #1109 to speak with the Meridian Life Science and 4bases teams about:

• Lyophilized NGS library preparation
• Enzymatic DNA fragmentation
• Glycerol-free enzymes for library preparation
• Custom reagent development and lyophilization
• KaryoSolver and sequencing-based cytogenomic analysis