Antithrombin is a critical serine protease inhibitor that regulates blood coagulation by neutralizing thrombin and other clotting factors, thereby preventing excessive clot formation. Deficiencies or dysfunctions in antithrombin can lead to an increased risk of thrombotic disorders, making it a vital marker in coagulation studies.
Lyophilized from 50 mM Tris-HCl, pH 8.0 containing 150 mM Sodium Chloride.
No
Antithrombin III is found in normal serum at 15 mg/100mL. Found at higher levels in plasma than in serum
because of complexing with thrombin during coagulation. Functions in the inhibition of the proteolytic
enzymes involved in blood coagulation and fibrinolysis, including factor Xa, plasmin, thrombin, and trypsin.
Potency is strongly enhanced by heparin. Molecular weight 58 kDa.
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