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Calcitonin

Calcitonin is a polypeptide hormone that is produced by the C-cells of the thyroid gland and it acts to reduce blood calcium and phosphate levels, opposing the effects of Parathyroid Hormone (PTH).

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Clear Results
20 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
MAb to Calcitonin
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
E01356M
MAb to Calcitonin
Monoclonal
Purified
Mouse
IgG1
EIA, Pr
MG
E01357M
MAb to ProCalcitonin
Monoclonal
Biotin
Mouse
IgG2a
EIA, Pr, WB
MG
E86420B
MAb to ProCalcitonin
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
E01340M
MAb to ProCalcitonin
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
E01341M
MAb to ProCalcitoninkatacalCIn
Monoclonal
Purified
Mouse
IgG1
LF, Pr
MG
E01342M
Rabbit anti Calcitonin
Antigen, Other
Neat
Rabbit
N/A
RIA
ML
D24112R
ProCalcitonin, Recombinant
Antigen, Other
Purified
E. coli
N/A
EIA
MG
A01454H
MAb to Calcitonin
Monoclonal
Purified
Mouse
IgG1
EIA
MG
E01329M
MAb to ProCalcitonin
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr, WB
MG
E86420M
MAb - ProCalcitonin/Calcitonin
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
E86131M
MAb to ProCalcitonin
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
E86813M
Human ProCalcitonin, Recomb.
Antigen, Other
Purified
E. coli
N/A
EIA, WB
MG
A01367H
MAb to ProCalcitonin
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr, WB
MG
E86494M
MAb - ProCalcitonin/Calcitonin
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
E86224M
MAb - ProCalcitonin/Calcitonin
Monoclonal
Purified
Mouse
IgG2b
EIA, Pr, WB
MG
E86561M
MAb to ProCalcitonin
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
E01291M
MAb to ProCalcitonin/calcitoni
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
E01253M
MAb - ProCalcitonin/katacalCIn
Monoclonal
Purified
Mouse
IgG1
EIA, Pr, WB
MG
E86412M
MAb to ProCalcitonin
Monoclonal
Purified
Mouse
IgG2a
EIA, Pr, WB
MG
E01308M

Calcitonin

Calcitonin is a 32 amino acid peptide cleaved from a larger prohormone. It plays a role in regulating serum calcium levels by decreasing its serum concentration in one of two ways: (1) by inhibiting the activity of osteoclasts in bone tissue, preventing them from resorbing bone or (2) inhibiting the reabsorption of calcium by the cells of the kidney, resulting in increased calcium excretion in the urine.

Calcium is an essential structural component of the skeleton and plays a key role in muscle contraction, blood coagulation, enzyme activity, neural excitability, secondary messengers, hormone release, and membrane permeability. Three major hormones (PTH, vitamin D, and calcitonin) interact to maintain a constant concentration of calcium in the body.

A large number of diseases are associated with abnormally increased or decreased levels of calcitonin including medullary thyroid carcinoma, lung cancer and certain tumors of the pancreas, namely insulinoma (an insulin-secreting tumor) and VIPoma (a vasoactive intestinal polypeptide-secreting tumor).

Diagnosis

Calcitonin is measured by quantitative sandwich immunoassays using antibodies that recognize the intact and mature form of calcitonin. High levels of calcitonin identify patients with nodular thyroid diseases and diagnose medullary thyroid cancers which originate from the C-cells of the thyroid gland.

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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