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C-Peptide

Insulin is a peptide hormone secreted by the β cells of the pancreatic islets of Langerhans and maintains normal blood glucose levels by facilitating cellular glucose uptake, regulating carbohydrate, lipid and protein metabolism and promoting cell division and growth through its mitogenic effects. C-peptide is a byproduct created when insulin is produced. Both insulin and C-peptide are created from a larger molecule called proinsulin which undergoes enzymatic cleavage to become des-31,32-proinsulin and des-64,65-proinsulin and eventually, insulin and C-peptide (an inactive peptide chain).

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8 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
MAb to C-peptide
Monoclonal
Purified
Mouse
IgG1
N/A
MG
MHP18-601
MAb to C-peptide
Monoclonal
Biotin
Mouse
IgG1
N/A
MG
MHP18-6014
MAb to C-peptide
Monoclonal
Purified
Mouse
IgG1
N/A
MG
MHP18-601CC
MAb to IGFBP-3
Monoclonal
Purified
Mouse
IgG1
CLIA, EIA, Pr, RIA
MG
K01410M
MAb to C-peptide
Monoclonal
Purified
Mouse
IgG1
EIA, LF
MG
E01336M
MAb to C-peptide
Monoclonal
Liquid
Mouse
IgG1
EIA, RIA
MG
E86710M
Rabbit anti C-peptide
Polyclonal
Neat
Rabbit
N/A
IHC(f), RIA, WB
ML
D24150R
MAb to C-peptide (proinsulin)
Monoclonal
Purified
Mouse
IgG1
EIA, RIA
MG
E86588M

C-peptide

Disorders most common to insulin and c-peptide dysregulation include diabetes, insulinomas (a tumor of the pancreas that causes excess insulin to be produced), hypokalaemia, Cushing’s syndrome, and kidney disease. The measurement of plasma insulin, C-peptide and proinsulin concentrations have been identified as the most useful test in identifying causes of hyperglycemia (high blood glucose) such as Type 1 and Type 2 diabetes which are chronic metabolic diseases due either to a lack of insulin secretion or reduced insulin sensitivity. Overall, raised levels indicate endogenous hyperinsulinaemia, which is often seen in people with early-stage type 2 diabetes mellitus, and low levels indicate type 1 diabetes.

Diagnosis

Early assays for insulin, proinsulin, and C-peptide were competitive RIAs, however, most commercial assays are now competitive (Insulin and C-peptide) or two-site enzyme immunoassays (total or intact proinsulin).

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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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