Close

Thyroid-stimulating hormone (TSH)

Thyroid-stimulating hormone (TSH) is a pituitary hormone that regulates thyroid function in conjunction with thyrotropin-releasing hormone (TRH). Specifically, TSH induces production of Thyroxine (T4) which is converted triiodothyronine (T3) and is responsible for stimulating the metabolism. TSH is secreted throughout life but reaches high levels during the periods of rapid growth and development, as well as in response to stress.

Have questions about a product?

Contact us to learn more about Meridian’s molecular or immunoassay reagent portfolio. We want to hear from you!

Contact A Specialist
Filter By:
Clear Results
21 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
N/A
MG
MAT04-127
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
N/A
MG
MAT04-176
Human TSH 98% Pure
Antigen
Purified
Human Pituitary
N/A
N/A
MG
H6T04-323
Goat anti Human TSH-beta
Polyclonal
Aff.Pur.
Goat
N/A
EIA, Pr
MG
G5T04-766
Human TSH >95% Pure
Antigen
Purified
Human Pituitary
N/A
EIA
MG
A75510H
MAb to TSH Intact
Monoclonal
Purified
Mouse
IgG1
EIA
MG
E01327M
MAb to TSH Beta
Monoclonal
Purified
Mouse
IgG1
EIA
MG
E01328M
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAT04-003
MAb to Human TSH - Alpha
Monoclonal
Purified
Mouse
IgG1,k
EIA
MG
E20370M
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAT04-410
Goat anti Human TSH - Beta
Polyclonal
Aff.Pur.
Goat
N/A
EIA, Pr, RIA
MG
D92409G
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MCT04-001
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAT04-005
MAb to TSH Intact
Monoclonal
Purified
Mouse
IgG1
EIA
MG
E86107M
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAT04-006
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MDT04-005
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAT04-252
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MCT04-005
MAb to TSH
Monoclonal
Purified
Mouse
IgG1,k
EIA, Pr
MG
MAT04-001
MAb to TSH Beta
Monoclonal
Purified
Sheep
N/A
EIA, IHC, Pr, WB
MG
E01318S
Goat anti TSH Intact
Polyclonal
Aff.Pur.
Goat
N/A
EIA, Pr
MG
D01242G

Thyroid-stimulating hormone (TSH)

TSH is produced by the pituitary gland and its main role is to control the production of the thyroid hormones, thyroxine (T4) and triiodothyronine (T3). When T3 and T4 concentrations are low, the production of TSH is increased, and, conversely, when T3 and T4 concentrations are high, TSH production is decreased. Any imbalance in this negative feedback loop can be the indication of a thyroid disease, such as hyperthyroidism or hypothyroidism.

The most common cause of hypo- and hyperthyroidism are autoimmune diseases such as Hashimoto’s disease when the immune system attacks the thyroid and causes hypothyroidism and Graves’ disease which involves an overactive thyroid leading to hyperthyroidism.

Diagnosis

TSH serum measurements are used as a first-line screening assay to help diagnose thyroid disorders and to monitor treatment of hypothyroidism and hyperthyroidism. The capability of a TSH assay to distinguish between normal and subnormal concentrations is critical and quantification capabilities of 0.01 ml U/L or lower yields information that is useful to clinicians referring patients with subnormal TSH concentrations.

TSH assays are generally competitive or two-site immunoassays They are prone to interference from several sources including (1) macro-TSH (the circulating form of TSH) (2) biotin (3) anti-streptavidin antibodies (4) anti-ruthenium (-Ru) antibodies (5) TH autoantibodies and (6) heterophilic antibodies. Heterophilic antibodies can be mitigated using animal IgG and HAMA blockers, however, due to lack of time and high cost, routine screening for interference is not feasible for testing all samples. Therefore, only samples in which interference is suspected generally require additional tests to further characterize the interference.

Get In Touch With A Specialist

Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

By submitting your information in this form, you agree that your personal information may be stored and processed in any country where we have facilities or service providers, and by using our “Contact Us” page you agree to the transfer of information to countries outside of your country of residence, including to the United States, which may provide for different data protection rules than in your country. The information you submit will be governed by our Privacy Statement.

Learn More About Us

Learn More

Welcome to

Please select your country to continue

Continue
EN