Meridian’s Approach to Custom Manufacturing Services
At Meridian, we specialize in custom antibody and protein manufacturing services, delivering high-performance reagents tailored to meet the diverse needs of our IVD customers. Our services include hybridoma conversion to animal-free formats, animal IgG conversion to a recombinant Animal-Origin-Free (AOF) alternative, and large-scale production of antibodies, antigens, and enzymes. Transitioning to animal-free manufacturing is a vital step toward more efficient, lower-risk, and better sustainable bioproduction methods.
What is Animal-Origin-Free (AOF)?
Animal origins free (AOF) means that the product does not contain materials derived from eukaryotic animals. Animal cell lines adapted to animal-free, chemically defined media are included.
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Conversion to Animal-Free
Recombinant antibodies offer numerous advantages over traditional hybridoma antibodies and can be produced using non-animal-derived materials. Our services include the conversion of your hybridoma-derived antibodies, or animal-derived blocker (e.g., goat IgG), into a recombinant, animal-free format. We provide a comprehensive solution encompassing sequencing, cloning, verification, expression, purification, and production, ensuring a seamless transition to a more ethical, stable, and efficient antibody source.
Advantages to Recombinant, Animal-Free Formats
- For lyophilization
- For air-drying
- Incorporation of dUTP
- Integration to platform
Large-Scale Manufacturing from Sequence or Clone (ISO 13485)
Discover Meridian’s tailored protein manufacturing solutions, which offer customizable packages to suit your project’s unique needs. We provide large-scale production of recombinant antigens, antibodies, and enzymes in quantities up to gram-scale for commercial applications.
Scaling up production involves utilizing adaptable methodologies to enhance expression capacity and meet increasing demands. Our commitment to quality is underscored by stringent quality control measures and compliance with industry standards, ensuring that every product meets the highest specifications for reliability and performance.
Our Cell Culture and Fermentation Equipment
Our facility is equipped with state-of-the-art cell culture and fermentation equipment, including single-use bioreactors and traditional stirred tank reactors with capacities up to 2,000L. Complimentary downstream processing equipment for protein purification and fill-and-finish operations is also available.
Protein Manufacturing Services (Up to 2,000L)
Versatile Expression Systems: E. coli, Yeast, Insect, CHO, HEK
Cell Culture
Fermenter
Single-use Bioreactor
Glass Bioreactor
Biostat® C-PLUS
Biostat® RM
CELBIC 25
Multi-shaker
CO2 incubator
Purification
ÄKTA Prime
ÄKTA Pilot
ÄKTA Avant
Sartoflow® Advanced
ÄKTA Flux
Chromatography Columns & Resins
QC & Fill and Finish
SDS-PAGE
CE-PAGE
HPLC (SEC, RP)
IEF
Western Blot
Bioburden
Concentration
Others – Functional or binding assays