Monkeypox
Monkeypox virus (MPXV) is a zoonotic double-stranded DNA enveloped virus that belongs to the orthopoxvirus genus of the Poxviridae family, which also includes variola (VARV), cowpox (CPX), and vaccinia (VACV) viruses. The monkeypox virus is endemic to Africa with two distinct genetic groups (clades): the west African clade and the central African (Congo Basin) clade.
For the second time in two years, the WHO has declared a global health emergency for mpox (monkeypox) virus, due to a newly emerging, highly contagious strain spreading across Africa. PCR is the only available FDA-approved test known to detect mpox virus, but it has limitations including complex sample collection and the requirement for sophisticated equipment and trained personnel. A rapid test, needing only a small sample of lesion swab and delivering results in 15 minutes, could dramatically slow the rate of transmission of the virus. Several immunodominant proteins for mpox have been identified and antibodies to the MPXV A29L protein have shown promise in lateral flow assays for the specific detection of mpox without cross-reactivity to other Orthopoxviruses. (doi.org/10.3389/fcimb.2024.1414224).
Meridian has paired MAbs to Mpox A29L that are ideal for ELISA or lateral flow applications, alongside recombinant antigens to mpox proteins P4a, A5L, A11L, H3L, and A29L for IgM testing.
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Monkeypox Products (7)
| Name | Type | Format | Host/Source | Isotype | Tested Apps | Unit | Catalog | Buffer | Immunogen | Recombinant | Description | Notes | SDS | COA | New Product | Recommended Product | Order a Sample | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MONKEYPOX A5L & A11L FUSION Ag | Antigen | Purified | E. coli | N/A | EIA,WB | BO | R01805 | No | View SDS | View COA | 0 | 0 | Order a Sample | ||||||
| MONKEYPOX H3L RECOMBINANT Ag | Antigen | Purified | E. coli | N/A | EIA,WB | BO | R01806 | No | View SDS | View COA | 0 | 0 | Order a Sample | ||||||
| MONKEYPOX P4a RECOMBINANT Ag | Antigen | Purified | E. coli | N/A | EIA,WB | BO | R01807 | No | View SDS | View COA | 0 | 0 | Order a Sample | ||||||
| Monkeypox A29L Rec. Ag | Antigen | Purified | HEK Cells | N/A | EIA,LF | MG | BN1179 | No | View SDS | View COA | 0 | 0 | Order a Sample | ||||||
| Monkeypox A29L Rec. Ag | Antigen | Purified | HEK Cells | N/A | EIA,LF | MG | BN1180 | No | View SDS | View COA | 0 | 0 | Order a Sample | ||||||
| mAb to Monkeypox A29L | Monoclonal | Purified, Liquid | Mouse | IgM,k | EIA,LF | MG | BN1206 | No | View SDS | View COA | 0 | 0 | Order a Sample | ||||||
| mAb to Monkeypox A29L | Monoclonal | Purified, Liquid | Mouse | IgG1,k | EIA,LF | MG | BN1207 | No | View SDS | View COA | 0 | 0 | Order a Sample |
Monkeypox Diagnosis and Prevention
Monkeypox is primarily diagnosed by molecular testing using PCR. However, very recent research suggests that monkeypox infections can be asymptomatic, which indicates the potential need for wider testing and isolation policies among people exposed to the virus (https://doi.org/10.1101/2022.07.04.22277226). If screening expands to individuals exposed to active monkeypox cases, then testing may need to include molecular testing on blood specimens and serology-based immunoassays that can detect acute subclinical and asymptomatic infections. In previous monkeypox outbreaks, such as the one in 2003 in the United States, serologic assays provided significant diagnostic support. Monkeypox IgM capture assays were able to distinguish between vaccinated and unvaccinated individuals with a sensitivity and specificity of 95% (https://doi.org/10.1128/CDLI.12.7.867-872.2005).
Catalogs & Brochures
Tropical & Vector-Borne DiseasesDevelop highly sensitive monkeypox MDx assays using Specimen-specific Master Mixes
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