Ribonucleases (RNases) are ubiquitous and can be introduced into experiments in many ways: for example co-purification during RNA isolation, a carryover from bare hands, and pipette tips. This RNase contamination can often go unnoticed. RNase Inhibitor (Ribonuclease Inhibitor) is ideal for RNA-sensitive applications such as RT-qPCR as even a small amount of RNase can be detrimental to the final experimental outcome.
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RNase Inhibitor is a recombinant protein that inhibits different RNases (A, B, C) by binding non-covalently in a 1:1 ratio. With an association constant of 1014 M, RNase Inhibitor is useful in any applications where the presence of RNases is a potential problem. RNase Inhibitor is tested for activity, SDS-PAGE purity, and the absence of endonucleases, nickases, and exonuclease.
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Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!