Scl-70
Scl-70 antigen is an abundant nuclear protein that is an extractable fragment (70 kD) of a larger protein (100-105kD), Topoisomerase I. Anti-Scl-70 antibodies are a serologic marker of diffuse cutaneous systemic sclerosis (dcSSc), a connective tissue disease characterized by microvascular damage and fibrosis of the skin and visceral organs. Autoantibodies to Scl-70 are also a specific serologic marker for systemic sclerosis and acrosclerosis, but are not usually present in other autoimmune rheumatic diseases unless some cutaneous symptoms of scleroderma are present.
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| Name | Type | Format | Host/Source | Isotype | Tested Apps | Unit | Catalog | SDS | COA | Request Sample |
|---|---|---|---|---|---|---|---|---|---|---|
| Scl-70 antigen | Antigen | Purified | Bovine Thymus | N/A | EIA | MG | A3C301B | SDS | COA | Request Sample |
| Scl-70 antigen | Antigen | Aff.Pur. | Rabbit Thymus | N/A | EIA | UT | A07322B | SDS | COA | Request Sample |
| Human anti Scl-70 antigen | Monoclonal | Purified | Human Donor | N/A | EIA,ID | ML | K07105H | SDS | COA | Request Sample |
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