Scl-70

Scl-70 antigen is an abundant nuclear protein that is an extractable fragment (70 kD) of a larger protein (100-105kD), Topoisomerase I. Anti-Scl-70 antibodies are a serologic marker of diffuse cutaneous systemic sclerosis (dcSSc), a connective tissue disease characterized by microvascular damage and fibrosis of the skin and visceral organs. Autoantibodies to Scl-70 are also a specific serologic marker for systemic sclerosis and acrosclerosis, but are not usually present in other autoimmune rheumatic diseases unless some cutaneous symptoms of scleroderma are present.

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Scl-70 Products (3)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
Scl-70 antigen Antigen Purified Bovine Thymus N/A EIA MG A3C301B View SDS View COA Order A Sample
Scl-70 antigen Antigen Aff.Pur. Rabbit Thymus N/A EIA UT A07322B View SDS View COA Order A Sample
Human anti Scl-70 antigen Monoclonal Purified Human Donor N/A EIA,ID ML K07105H View SDS View COA Order A Sample

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