Close

Parainfluenza

Human parainfluenza viruses (HPIVs) commonly cause upper and lower respiratory illnesses. The symptoms of HPIVs are not severe enough to cause concern in healthy adults. However, they can be life-threatening in an infant, the elderly, or anyone with a compromised or weakened immune system.

Have questions about a product?

Contact us to learn more about Meridian’s molecular or immunoassay reagent portfolio. We want to hear from you!

Contact A Specialist
Filter By:
Clear Results
15 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
MAb to Parainfluenza Type 2
Monoclonal
Purified
Mouse
IgG1
N/A
MG
C01307M
MAb to Parainfluenza Type 3
Monoclonal
Purified
Mouse
IgG2a
N/A
MG
C01308M
MAb to Parainfluenza Type 1
Monoclonal
Purified
Mouse
IgG2a
N/A
MG
C01306M
Parainfluenza Type 2 antigen
Antigen, Other
Lysate
Vero Cells
N/A
EIA, WB
ML
R02902
Parainfluenza Type 3 antigen
Antigen, Other
Lysate
Vero Cells
N/A
EIA, WB
ML
R02002
MAb to Parainfluenza 1
Monoclonal
Purified
Mouse
IgG2b
EIA, IFA
MG
C65122M
MAb to Parainfluenza Type 2
Monoclonal
Purified
Mouse
IgG2a
IFA
MG
C65241M
Goat anti Parainfluenza 1
Polyclonal
Purified
Goat
N/A
IFA
ML
B65121G
Goat anti-Parainfluenza 2&3
Polyclonal
Purified
Goat
N/A
EIA, IFA
ML
B65130G
MAb to Parainfluenza Type 1
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65492M
Goat anti-Parainfluenza 2+3
Polyclonal
HRP
Goat
N/A
EIA, ICC
ML
B65233G
MAb to Parainfluenza Type 3
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65329M
MAb to Parainfluenza Type 3
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65467M
MAb to Parainfluenza Type 1&3
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA, Pr
MG
C65738M
MAb to Parainfluenza Type 2
Monoclonal
Purified
Mouse
IgG2a
IFA
MG
C65300M

Parainfluenza

There are four types of parainfluenza viruses which cause respiratory infections. The exact type of infection, the symptoms, and the location of the infection depends on the type of virus:

  • HPIV-1: the leading cause of croup in children
  • HPIV-2: also causes croup in children, but it is detected with less frequency than HPIV-1
  • HPIV-3: mainly associated with bronchiolitis and pneumonia
  • HPIV-4 (includes subtypes 4A and 4B): not as well known, but may cause mild to severe respiratory tract illnesses

HPIVs are spread from person to person by direct contact or exposure to contaminated secretions from the nose or throat. Most children are infected with HPIV-3 by the age of two years and with HPIV-1 and HPIV-2 by the age of five years. HPIV-3 infections are a major cause of pneumonia and bronchiolitis in infected infants under 6 months old.

Diagnosis

Laboratory diagnosis of parainfluenza viruses can be performed by isolation and detection of the virus in cell culture, or detection of viral antigens directly within respiratory tract secretions using immunofluorescence (IFA), enzyme immunoassays (EIA), fluroimmunoassays or polymerase chain reaction (PCR). Also, analysis of specific IgG antibodies showing a subsequent rise in titer following infection (using paired serum specimens) can demonstrate an acute infection. However, individual parainfluenza virus types are known to cross-react making subtyping difficult. Hemagglutination inhibition tests (HIT), complement fixation (CF) and neutralization tests (NT) can be performed to differentiate the HPIV types by evaluating the specific IgM, IgG and IgA antibody titers.

During the acute phase of infection, two thirds of patients show a high serum titer of specific HPIV IgM antibodies which persist 2-11 weeks. In 70 – 80% of patients, an increase in specific IgG antibodies (at least fourfold within 10 days) is found during primary infection with HPIV-1, 2 or 3. New EIA assays rely on purified viral envelope glycoprotein and nucleocapsid preparations. In differential diagnosis, tests for other paramyxoviruses like mumps, pneumonia and simian virus type 5 must be performed due to possible cross-reactions.

Get In Touch With A Specialist

Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

By submitting your information in this form, you agree that your personal information may be stored and processed in any country where we have facilities or service providers, and by using our “Contact Us” page you agree to the transfer of information to countries outside of your country of residence, including to the United States, which may provide for different data protection rules than in your country. The information you submit will be governed by our Privacy Statement.

Learn More About Us

Learn More

Welcome to

Please select your country to continue

Continue