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| Library | Average mapped reads (%) |
|---|---|
| Lyophilized reagents | 99.79 ± 0.04 |
| Liquid reagents | 99.79 ± 0.12 |
Comparison of libraries created using lyophilized and liquid formulations. The table shows mapping efficiency, while the chart displays the GC content of the libraries generated with lyophilized and liquid reagents. In both cases, lyophilized and liquid formulations showed similar results, with good mapping efficiency and comparable GC content.
Meridian’s glycerol-free NGS Library Prep Enzymes enable high-fidelity, high-efficiency library preparation, allowing sequencing kits to be shipped and stored at ambient temperature for greater accessibility. Ambient-temperature NGS assays eliminate cold-chain logistics, expanding access to genomic testing in resource-limited settings. By driving scalable, high-performance sequencing technologies, Meridian is bridging the gap, making NGS-based diagnostics more accessible, efficient, and impactful worldwide.
Next-generation sequencing (NGS) is widely used in clinical diagnostics and precision medicine, with applications spanning oncology, infectious disease, reproductive health, and genetic disorder screening. In cancer care, NGS supports companion diagnostics (CDx) for targeted therapies, minimal residual disease (MRD) monitoring, and liquid biopsy for non-invasive tumor detection. It plays a crucial role in infectious disease diagnostics, identifying pathogens, antimicrobial resistance markers, and tracking viral outbreaks. In reproductive medicine, NGS enables non-invasive prenatal testing (NIPT), carrier screening, and preimplantation genetic testing (PGT). Additionally, it is instrumental in rare disease diagnosis, pharmacogenomics, transplant medicine, and neurological disorder screening, offering personalized insights for treatment decisions. As NGS technology advances, its role in cardiovascular risk assessment, immunogenetics, and population genomics continues to expand, further integrating precision medicine into routine clinical practice.
Next-Generation Sequencing (NGS)
Next-generation sequencing has become remarkably powerful but in many ways, it is still designed for a world of centralized laboratories and tightly controlled environments. Despite
Whole genome sequencing (WGS) has become a cornerstone of modern genomics, powering discovery in oncology, infectious disease, inherited disorders, and even agriculture. By providing complete
Cancer remains one of the world’s most complex diseases, arising from an interplay of genetic, environmental, and infectious factors. While inherited mutations and carcinogens are
In antibody-based immunoassays, antigen selection is the key biological decision driving assay performance. The structure, epitope integrity, and expression format of the antigen determine how
The 2025 flu season has been more intense than recent years, with elevated infection rates and notable pressure on healthcare systems1. Alongside seasonal influenza, several
The article outlines four pivotal strategies for enhancing sustainability in diagnostic testing. It emphasizes the importance of reducing waste and environmental impact through innovative approaches such as optimizing test designs and utilizing eco-friendly materials. Additionally, it discusses the benefits of lyophilized reagents, which can decrease the carbon footprint associated with cold chain logistics. The piece is insightful, offering practical solutions for making diagnostic practices more sustainable while maintaining efficiency and effectiveness.
References: Zalis, M., Viana Veloso, G. G., Aguiar Jr., P. N., Gimenes, N., Reis, M. X., Matsas, S., & Ferreira, C. G. (2024). Next-generation sequencing impact on cancer care: Applications, challenges, and future directions. Frontiers in Genetics, 15, 1420190. https://doi.org/10.3389/fgene.2024.1420190
Meric-Bernstam, F., Brusco, L., Daniels, M., Wathoo, C., Bailey, A. M., Strong, L., & Shaw, K. (2019). Clinical applications of next-generation sequencing in precision oncology. NPJ Precision Oncology, 3, 4. https://doi.org/10.1038/s41698-019-0073-4
To detect more alterations, consider adding companion testing to NGS. (n.d.). Targeted Oncology. Retrieved from https://www.targetedonc.com/view/to-detect-more-alterations-consider-adding-companion-testing-to-ngs
| Specimen Type |
|---|
| Application |
| Catalog |
| Sizes |
| Wet(Liquid) |
| Air-Dryable |
| Glycerol-Free |
| Lyo-Ready |
| Concentration |
| High Concentration |
| Description |
| Request Sample |
