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hCG

Human chorionic gonadotropin (hCG) is a placental hormone initially secreted by cells that surround an implanted embryo in pregnancy. Its primary role is to maintain the function of the corpus luteum during the first 3 to 4 months of pregnancy. The protein has many other roles including stimulating the onset of fetal gonadal steroidogenesis.

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hCG Products (19)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog Buffer Immunogen Recombinant Description Notes SDS COA New Product Recommended Product Order a Sample
MAb to hCG Beta, Free Monoclonal Purified Mouse IgG1 EIA,Pr MG E01323M No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1 LF MG E31586M No View SDS View COA 0 Order a Sample
MAb to hCG Alpha Monoclonal Purified Mouse IgG EIA,Pr MG E86051M No View SDS View COA 0 Order a Sample
MAb to hCG Alpha Monoclonal Purified Mouse IgG2b Pr,LF MG E86082M No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG2a EIA,LF,Pr MG E86308M No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1 LF,Pr,EIA MG E86820M No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAF05-019 No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1,k EIA MG MAF05-020 No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1,k EIA,LF,WB MG MAF05-023 No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAF05-025 No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAF05-043 No View SDS View COA 0 Order a Sample
MAb to hCG Beta Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAF05-627 No View SDS View COA 0 Order a Sample
MAb to hCG, Beta Monoclonal Purified Mouse IgG EIA,LF,WB MG MKF05-148 No View SDS 0 Order a Sample
hCG >=95% Pure Antigen Purified Human N/A EIA MG A01378H No View SDS View COA 0 Order a Sample
hCG Beta >=95% Pure Antigen Purified Human N/A EIA MG A01376H No View SDS View COA 0 Order a Sample
hCG Alpha >=95% Pure Antigen Purified Human N/A N/A MG A01377H No View SDS View COA 0 Order a Sample
hCG, Usp Grade Antigen Purified Human Pregnancy Urine N/A N/A MG A01322H No View SDS View COA 0 Order a Sample
hCG Beta >= 98% Pure Antigen Purified Human Pregnancy Urine N/A N/A MG A01278H No View SDS View COA 0 Order a Sample
hCG Antigen Purified Human Pregnancy Urine N/A EIA MG A38980H No View SDS View COA 0 Order a Sample

Human chorionic gonadotropin (hCG)

Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein with an alpha subunit (identical to that of LH, FSH and TSH) and a unique β(beta)-subunit. The hormone is secreted as soon as the trophoblast implants in the uterine wall and it is at its highest concentration between the 7th and 10th weeks of pregnancy. The urine of women in the first month of pregnancy contains enough hCG to be detected by ELISA.

Total hCG is commonly used to confirm and monitor pregnancy, but it also has clinical utility in detecting miscarriages, preeclampsia, neoplasms, and trophoblastic diseases. Quantitative free β-hCG tests can also be used as tumor marker tests in gestational trophoblastic disease and in certain testicular tumors where the ratio of the free β subunit to intact hCG can be abnormally high. Free β-hCG may also have clinical utility in first-and second-trimester prenatal screening for Down syndrome and other chromosomal anomalies.

Diagnosis

Qualitative hCG assays are based on the two-site sandwich enzyme immunoassay principle typically using lateral flow technology and can detect hCG levels as low as 10 mIU/mL-100ml U/mL. They are prone to heterophile antibody interference, resulting in occasional false-positive results, and in rare cases, interference due to extremely high titers of antibodies to analyte-specific antibodies, streptavidin or ruthenium can occur.

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