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Herpes Simplex Virus (HSV)

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are highly contagious infections that are lifelong and cause recurrent symptoms of painful blisters or open sores. HSV-1 is mainly transmitted by oral-to-oral contact and HSV-2 is a sexually transmitted infection that causes genital herpes. Neonatal herpes is rare but dangerous condition that can occur when an infant is exposed to HSV (HSV-1 or HSV-2) in the genital tract during delivery.

Herpes are common infections worldwide. However, the majority of infected individuals remain undiagnosed because they are asymptomatic.

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Clear Results
44 Results
Name
Type
Format
Host/Source
Isotype
Tested Apps
Unit
Catalog
SDS
COA
Request Sample
HSV-2 (gG-2) Recombinant
Antigen
Purified
E. coli
N/A
CLIA, EIA, LF, WB
MG
R01673
MAb to HSV-2 gD
Monoclonal
Purified
Mouse
IgG1
EIA, IFA
MG
C01859M
MAb to HSV-1
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
C01290M
MAb to HSV-1
Monoclonal
Purified
Mouse
IgG3
EIA
MG
C01291M
MAb to HSV-2
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
C01292M
HSV-2 antigen Grade III
Antigen
Purified
Vero Cells
N/A
EIA
MG
GB9521
MAb to HSV-1 Glycoprotein E
Monoclonal
Purified
Mouse
IgG2a
EIA, IFA
MG
C65120M
Goat A' Herpes Simplex Type-1
Polyclonal
FITC
Goat
N/A
EIA, IFA
ML
B65133G
Goat A' Herpes Simplex Type-1
Polyclonal
HRP
Goat
N/A
EIA
ML
B65134G
MAb to HSV-2, gG-2
Monoclonal
Ascites
Mouse
IgG1
WB
ML
C66501M
MAb to HSV-2 Glycoprotein G
Monoclonal
Purified
Mouse
IgG
IFA
MG
C65116M
HSV-2 gG
Antigen
Purified
Synthetic
N/A
EIA, WB
MG
R01594
Rabbit A' Herpes Simplex Virus
Polyclonal
HRP
Rabbit
N/A
EIA, ICC
ML
B65205R
Rabbit anti-HSV-1 & 2
Polyclonal
Purified
Rabbit
N/A
IFA, WB
ML
B65107R
Sheep A' Herpes Simplex Type-2
Polyclonal
HRP
Sheep
N/A
EIA, ICC, WB
ML
B65124S
Sheep A' Herpes Simplex Type-2
Polyclonal
FITC
Sheep
N/A
EIA, IFA, WB
ML
B65123S
MAb to HSV-2 Regulatory Prot.
Monoclonal
Purified
Mouse
IgG
IFA
MG
C65115M
HSV-1 gD, Recombinant
Antigen
Purified
Pichia pastoris
N/A
CLIA, WB
MG
VTI510
HSV-1 gG, Recombinant
Antigen
Aff.Pur.
S. cerevisiae
N/A
CLIA, WB
MG
VTI520
HSV-1 antigen, Concentrate
Antigen
Partially Purified
Vero Cells
N/A
EIA, WB
ML
7309
HSV-2 antigen, Concentrate
Antigen
Partially Purified
Vero Cells
N/A
EIA
ML
7749
HSV-gG2 Native antigen
Antigen
Purified
Vero Cells
N/A
EIA
ML
EV9287
HSV-1 antigen Grade III
Antigen
Purified
Vero Cells
N/A
EIA
MG
GB9520
MAb to HSV-2 gG-2
Monoclonal
Purified
Mouse
IgG1
WB
MG
C66516M
Goat A' Herpes Simplex Type-1
Polyclonal
Purified
Goat
N/A
EIA, IFA
ML
B65131G
MAb to Herpes Simplex Virus-1
Monoclonal
Purified
Mouse
IgG2
IFA
MG
C65141M
MAb to Herpes Type 6 p150
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, IHC, IP
MG
C65200M
MAb to Herpes Type 6 Gp90
Monoclonal
Purified
Mouse
IgG2
IHC, IP
MG
C65302M
Sheep A' Herpes Simplex Type-2
Polyclonal
Purified
Sheep
N/A
EIA, IFA, WB
ML
B65121S
MAb to HSV-1 gD
Monoclonal
Purified
Mouse
IgG1
EIA, IP, WB
MG
C8A020M
MAb to HSV-2 Glycoprotein E
Monoclonal
Purified
Mouse
IgG2
EIA
MG
C65901M
HSV-2 gG2 Recombinant
Antigen
Purified
S. cerevisiae
N/A
EIA, WB
MG
VTI530
MAb to Herpes Type 6 Early Ag
Monoclonal
Purified
Mouse
IgG1
EIA, IFA, IHC, IP, WB
MG
C65206M
HSV-2 Ag (g Strain)
Antigen
Purified
Vero Cells
N/A
EIA
MG
R29130
HSV-2 gD, Recombinant
Antigen
Purified
Pichia pastoris
N/A
EIA, WB
MG
VTI540
HSV-2 (gG) Recombinant
Antigen
Purified
E. coli
N/A
EIA, WB
MG
R18350
HSV-2 (gD) Recomb
Antigen
Purified
E. coli
N/A
EIA, WB
MG
R18530
HSV-1 (gD) Recomb
Antigen
Purified
E. coli
N/A
EIA, WB
MG
R18430
MAb to HSV-2
Monoclonal
Purified
Mouse
IgG1
EIA, WB
MG
C86302M
MAb to HSV-1&2 gD
Monoclonal
Purified
Mouse
IgG1
EIA, IFA
MG
C65912M
MAb to HSV-1 gG-1
Monoclonal
Purified
Mouse
IgG2a
EIA, WB
MG
C66150M
HSV-1 antigen
Antigen
Partially Purified
Vero Cells
N/A
EIA, WB
ML
7305
HSV-2 antigen
Antigen
Custom
Vero Cells
N/A
EIA
ML
7705
MAb to HSV 1&2, Glycoprotein D
Monoclonal
Purified
Mouse
IgG2a
EIA
MG
C01294M

Herpes Simplex Virus (HSV)

HSV-1 is usually transmitted during childhood through contact with oral secretions (cold sores). Seroprevalence studies indicate about 60% of adults in the United States are infected with this virus. HSV-2 is usually spread by sexual contact (genital herpes). Consequently, this infection usually occurs later in life and the seroprevalence rates vary dramatically by geographic region. Both HSV-1 and HSV-2 establish a lifelong, latent infection in the nervous system and there is no cure. Antiviral medications can reduce the frequency, duration and severity of outbreaks and over a period of several years, many infected individuals experience less severe symptoms and fewer outbreaks, although they are still contagious to others. The risk for neonatal herpes is greatest when a mother acquires HSV infection for the first time in late pregnancy in part because the levels of HSV in the genital tract are highest early in infection. Many infants infected with HSV are born prematurely and approximately 4% can develop congenital HSV which has serious consequences including death.

Congenital Disease

In most cases, babies contract congenital herpes in the birth canal during delivery (especially if the mother has an active outbreak of genital herpes at the time of delivery). In rare circumstances, it is possible to be infected in the uterus or immediately after birth (from being kissed or having other contact with someone who has herpes mouth sores). Congenital HSV is a serious condition and affects about 1 out of every 3,000-20,000 live births. Detection and prevention are difficult because the infected mother is typically asymptomatic. Congenital herpes symptoms usually appear within the first month of the infant’s life and antiviral treatments such as vidarabine and acyclovir have proven helpful to reduce the severity of the disease. However, infants with systemic herpes or encephalitis often do poorly, despite antiviral medications and early treatment.

Diagnosis

Diagnostic methods for herpes include serological tests such as ELISA and IFA, as well as PCR blood tests and cell culture. Due to a high degree of genetic similarity between HSV-1 and HSV-2, most viral proteins induce a cross-reactive antibody response that hampers the discrimination between HSV-1 and HSV-2 infections using serological approaches. However, since the discovery of the serologically distinct HSV viral envelope glycoproteins gG-1 (HSV-1) and gG-2 (HSV-2), new type-specific immunoassays have been developed that are capable of discriminating between HSV-1 and HSV-2 infections. Since antibodies may take several weeks to reach detectable levels after primary infection, negative results should be confirmed by repeat testing 4 to 6 weeks after a suspected early infection.

Get In Touch With A Specialist

Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!

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