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Herpes

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are highly contagious infections that are lifelong and cause recurrent symptoms of painful blisters or open sores. HSV-1 is mainly transmitted by oral-to-oral contact and HSV-2 is a sexually transmitted infection that causes genital herpes. Neonatal herpes is rare but dangerous condition that can occur when an infant is exposed to HSV (HSV-1 or HSV-2) in the genital tract during delivery.

Herpes are common infections worldwide. However, the majority of infected individuals remain undiagnosed because they are asymptomatic.

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
HSV-2 antigen, Concentrate Antigen Partially Purified Vero Cells N/A EIA ML 7749 SDS COA Request Sample
HSV-2 antigen Antigen Custom Vero Cells N/A EIA ML 7705 SDS COA Request Sample
HSV-1 antigen, Concentrate Antigen Partially Purified Vero Cells N/A EIA,WB ML 7309 SDS COA Request Sample
HSV-1 antigen Antigen Partially Purified Vero Cells N/A EIA,WB ML 7305 SDS COA Request Sample
HSV-2 gD, Recombinant Antigen Purified Pichia pastoris N/A WB,EIA MG VTI540 SDS COA Request Sample
HSV-2 gG2 Recombinant Antigen Purified S. cerevisiae N/A WB,EIA MG VTI530 SDS COA Request Sample
HSV-1 gG, Recombinant Antigen Aff.Pur. S. cerevisiae N/A WB,CLI MG VTI520 SDS COA Request Sample
HSV-1 gD, Recombinant Antigen Purified Pichia pastoris N/A WB,CLI MG VTI510 SDS COA Request Sample
HSV-2 Ag (g Strain) Antigen Purified Vero Cells N/A EIA MG R29130 COA Request Sample
HSV-2 (gG) Recomb Antigen Purified E. coli N/A EIA,WB MG R18530 SDS COA Request Sample
HSV-1 (gD) Recomb Antigen Purified E. coli N/A EIA,WB MG R18430 COA Request Sample
HSV-2 (gG) Recombinant Antigen Purified E. coli N/A EIA,WB MG R18350 SDS COA Request Sample
HSV-2 (gG-2) Recombinant Antigen Purified E. coli N/A EIA,WB,CLI,LF MG R01673 SDS COA Request Sample
HSV-2 gG Antigen Purified Synthetic N/A EIA,WB MG R01594 COA Request Sample
HSV-2 antigen Grade III Antigen Purified Vero Cells N/A EIA MG GB9521 SDS COA Request Sample
HSV-1 antigen Grade III Antigen Purified Vero Cells N/A EIA MG GB9520 SDS COA Request Sample
HSV-gG2 Native antigen Antigen Purified Vero Cells N/A EIA ML EV9287 SDS COA Request Sample
MAb to HSV-2 Monoclonal Purified Mouse IgG1 WB,EIA MG C86302M SDS COA Request Sample
MAb to HSV-1 gD Monoclonal Purified Mouse IgG1 EIA,IP,WB MG C8A020M SDS COA Request Sample
MAb to HSV-2, gG-2 Monoclonal Ascites Mouse IgG1 WB ML C66501M SDS COA Request Sample
MAb to HSV-1 gG-1 Monoclonal Purified Mouse IgG2a WB,EIA MG C66150M SDS COA Request Sample
MAb to HSV-1&2 gD Monoclonal Purified Mouse IgG1 EIA,IFA MG C65912M SDS COA Request Sample
MAb to HSV-2 Glycoprotein E Monoclonal Purified Mouse IgG2 EIA MG C65901M SDS COA Request Sample
MAb to Herpes Type 6 Gp90 Monoclonal Purified Mouse IgG2 IHC,IP MG C65302M COA Request Sample
MAb to Herpes Type 6 Early Ag Monoclonal Purified Mouse IgG1 EIA,IFA,IHC,IP,WB MG C65206M SDS COA Request Sample
MAb to Herpes Type 6 p150 Monoclonal Purified Mouse IgG1 EIA,IFA,IHC,IP MG C65200M COA Request Sample
MAb to Herpes Simplex Virus-1 Monoclonal Purified Mouse IgG2 IFA MG C65141M SDS COA Request Sample
MAb to HSV-1 Glycoprotein E Monoclonal Purified Mouse IgG2a EIA,IFA MG C65120M COA Request Sample
MAb to HSV-2 Glycoprotein G Monoclonal Purified Mouse IgG IFA MG C65116M SDS COA Request Sample
MAb to HSV-2 Regulatory Prot. Monoclonal Purified Mouse IgG IFA MG C65115M COA Request Sample
MAb to HSV-2 gD Monoclonal Purified Mouse IgG1 EIA,IFA MG C01859M SDS COA Request Sample
MAb to HSV-2 Monoclonal Purified Mouse IgG2a EIA MG C01292M SDS COA Request Sample
MAb to HSV-1 Monoclonal Purified Mouse IgG3 EIA MG C01291M COA Request Sample
MAb to HSV-1 Monoclonal Purified Mouse IgG2a EIA MG C01290M SDS COA Request Sample
Rabbit A' Herpes Simplex Virus Polyclonal HRP Rabbit N/A EIA,ICC ML B65205R SDS COA Request Sample
Goat A' Herpes Simplex Type-1 Polyclonal HRP Goat N/A EIA ML B65134G SDS COA Request Sample
Goat A' Herpes Simplex Type-1 Polyclonal FITC Goat N/A EIA,IFA ML B65133G COA Request Sample
Goat A' Herpes Simplex Type-1 Polyclonal Purified Goat N/A EIA,IFA ML B65131G SDS COA Request Sample
Sheep A' Herpes Simplex Type-2 Polyclonal HRP Sheep N/A EIA,ICC,WB ML B65124S SDS COA Request Sample
Sheep A' Herpes Simplex Type-2 Polyclonal FITC Sheep N/A EIA,IFA,WB ML B65123S COA Request Sample
Sheep A' Herpes Simplex Type-2 Polyclonal Purified Sheep N/A EIA,IFA,WB ML B65121S SDS COA Request Sample
Rabbit anti-HSV-1 & 2 Polyclonal Purified Rabbit N/A IFA,WB ML B65107R SDS COA Request Sample

Herpes Simplex Virus (HSV)

HSV-1 is usually transmitted during childhood through contact with oral secretions (cold sores). Seroprevalence studies indicate about 60% of adults in the United States are infected with this virus. HSV-2 is usually spread by sexual contact (genital herpes). Consequently, this infection usually occurs later in life and the seroprevalence rates vary dramatically by geographic region. Both HSV-1 and HSV-2 establish a lifelong, latent infection in the nervous system and there is no cure. Antiviral medications can reduce the frequency, duration and severity of outbreaks and over a period of several years, many infected individuals experience less severe symptoms and fewer outbreaks, although they are still contagious to others. The risk for neonatal herpes is greatest when a mother acquires HSV infection for the first time in late pregnancy in part because the levels of HSV in the genital tract are highest early in infection. Many infants infected with HSV are born prematurely and approximately 4% can develop congenital HSV which has serious consequences including death.

Congenital Disease

In most cases, babies contract congenital herpes in the birth canal during delivery (especially if the mother has an active outbreak of genital herpes at the time of delivery). In rare circumstances, it is possible to be infected in the uterus or immediately after birth (from being kissed or having other contact with someone who has herpes mouth sores). Congenital HSV is a serious condition and affects about 1 out of every 3,000-20,000 live births. Detection and prevention are difficult because the infected mother is typically asymptomatic. Congenital herpes symptoms usually appear within the first month of the infant’s life and antiviral treatments such as vidarabine and acyclovir have proven helpful to reduce the severity of the disease. However, infants with systemic herpes or encephalitis often do poorly, despite antiviral medications and early treatment.

Diagnosis

Diagnostic methods for herpes include serological tests such as ELISA and IFA, as well as PCR blood tests and cell culture. Due to a high degree of genetic similarity between HSV-1 and HSV-2, most viral proteins induce a cross-reactive antibody response that hampers the discrimination between HSV-1 and HSV-2 infections using serological approaches. However, since the discovery of the serologically distinct HSV viral envelope glycoproteins gG-1 (HSV-1) and gG-2 (HSV-2), new type-specific immunoassays have been developed that are capable of discriminating between HSV-1 and HSV-2 infections. Since antibodies may take several weeks to reach detectable levels after primary infection, negative results should be confirmed by repeat testing 4 to 6 weeks after a suspected early infection.

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