Blockers & Immunoglobulins

Immunoassay blockers are used in diagnostic assays to reduce non-specific binding and other interference that can lead to false-positive results. Specifically, interference from human anti-mouse antibodies (HAMA), rheumatoid factor (RH), and heterophilic antibodies (HA) are a major concern in both paired monoclonal sandwich assays and competitive assays. Specialized blockers are required in these assays to reduce any interference and to ensure the assay's accuracy.

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Immunoassay Blocking Reagents

Blocking reagents are essential to ensure reliable immunoassay results. They are widely used in research and clinical settings for the development of a wide variety of immunoassays, such as ELISA, CLIA, LFA (lateral flow assay) and more. Discover tailored solutions to enhance your assay development processes.

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Why We Are Second To None

Meridian’s range of blockers includes universal (active & passive) blockers such as the TRU Block^™ series, active blockers such as K-BLOCK^™, and passive blockers such as Mouse IgG. TRU Block^™ (a next-generation blocker) is the result of years of research and development aimed at creating the most powerful immunoassay interference blocker on the market. It provides broad coverage against HAMA, HA, and RF and works in several assay types, including ELISA and Lateral Flow. IVD manufacturers are able to use this active blocker at reduced concentrations and achieve higher assay performance.